Search Results - "Naser, Saleh A"

The Role of Notch Signaling in Macrophages during Inflammation and Infection: Implication in Rheumatoid Arthritis? by Keewan, Esra'a, Naser, Saleh A

“…Notch signaling coordinates numerous cellular processes and has been implicated in many pathological conditions, including rheumatoid arthritis (RA). Although…”
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The dual role of interleukin-6 in Crohn's disease pathophysiology by Alhendi, Ala', Naser, Saleh A

“…Interleukin-6 (IL-6) is a key mediator cytokine of the immune response as well as a regulator of many physiological and pathological processes. In Crohn's…”
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In vitro neutralization of IL-6 receptor exacerbates damage to intestinal epithelial cells during Mycobacterium avium paratuberculosis infection by Alhendi, Ala', Naser, Saleh A

“…Like TNFα, IL-6 is upregulated in Crohn's disease (CD) especially in patients associated with (MAP) infection, and both cytokines have been targeted as a…”
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The Role of Short-Chain Fatty Acids and Altered Microbiota Composition in Autism Spectrum Disorder: A Comprehensive Literature Review by Lagod, Piotr P, Naser, Saleh A

“…Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by deficits in communication and social interactions, restrictive and…”
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Enteropathogenic infections modulate intestinal serotonin transporter (SERT) function by activating Toll-like receptor 2 (TLR-2) in Crohn’s disease by Qasem, Ahmad, Naser, Abed Elrahman, Naser, Saleh A.

“…Serotonin (5-hydroxytryptamine [5-HT]) is an intestinal neuromodulator that regulates several essential enteric physiological functions such as absorption or…”
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Anti-TNF-α agents Modulate SARS-CoV-2 Receptors and Increase the Risk of Infection Through Notch-1 Signaling by Keewan, Esra’a, Beg, Shazia, Naser, Saleh A.

“…Although millions of patients with underlining conditions are treated primarily with anti-TNF-α agents, little is known about the safety of this standard…”
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An In Vivo Model of Propionic Acid-Rich Diet-Induced Gliosis and Neuro-Inflammation in Mice (FVB/N-Tg(GFAPGFP)14Mes/J): A Potential Link to Autism Spectrum Disorder by Lagod, Piotr P, Abdelli, Latifa S, Naser, Saleh A

“…Evidence shows that Autism Spectrum Disorder (ASD) stems from an interplay of genetic and environmental factors, which may include propionic acid (PPA), a…”
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Divergent Effect of Cigarette Smoke on Innate Immunity in Inflammatory Bowel Disease: A Nicotine-Infection Interaction by AlQasrawi, Dania, Qasem, Ahmad, Naser, Saleh A

“…Cigarette smoke (CS) has adverse effects in patients with Crohn's disease (CD), an inflammatory bowel disease (IBD) that has been associated with microbial…”
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Mycobacterium avium subspecies paratuberculosis causes Crohn’s disease in some inflammatory bowel disease patients by Naser, Saleh A, Sagramsingh, Sudesh R, Naser, Abed S, Thanigachalam, Saisathya

“…Crohn’s disease(CD)is a chronic inflammatory condition that plagues millions all over the world.This debilitating bowel disease can start in early childhood…”
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Pathophysiology of autism spectrum disorders:Revisiting gastrointestinal involvement and immune imbalance by Samsam, Mohtashem, Ahangari, Raheleh, Naser, Saleh A

“…Autism spectrum disorders(ASD)comprise a group of neurodevelopmental abnormalities that begin in early childhood and are characterized by impairment of social…”
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Coronavirus Disease 2019 (COVID-19) Diagnostic Tools: A Focus on Detection Technologies and Limitations by Qasem, Ahmad, Shaw, Ameera M., Elkamel, Erij, Naser, Saleh A.

“…The ongoing coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a severe threat to human…”
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Modulation of PTPN2/22 Function by Spermidine in CRISPR-Cas9-Edited T-Cells Associated with Crohn's Disease and Rheumatoid Arthritis by Shaw, Ameera M, Qasem, Ahmad, Naser, Saleh A

“…Crohn's Disease (CD) and Rheumatoid Arthritis (RA) share some single nucleotide polymorphisms (SNPs) in protein tyrosine phosphatase non-receptor types 2 and…”
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Mycobacterium avium paratuberculosis Infection Suppresses Vitamin D Activation and Cathelicidin Production in Macrophages through Modulation of the TLR2-Dependent p38/MAPK-CYP27B1-VDR-CAMP Axis by Talafha, Muna M, Qasem, Ahmad, Naser, Saleh A

“…Vitamin D plays a vital role in modulating both innate and adaptive immune systems. Therefore, vitamin D deficiency has been associated with higher levels of…”
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Attenuation of Excess TNF-α Release in Crohn's Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-β Mediated Immunosuppression Through Modulation of TACE Trafficking by Louis, Taylor J, Qasem, Ahmad, Naser, Saleh A

“…TNFα converting enzyme (TACE) is a transmembrane metalloprotease that sheds an assortment of signaling receptors, cytokines, growth factors, and…”
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Notch-1 Signaling Modulates Macrophage Polarization and Immune Defense against Mycobacterium avium paratuberculosis Infection in Inflammatory Diseases by Keewan, Esra’a, Naser, Saleh A.

“…Despite the extensive research on Notch signaling involvement in inflammation, its specific role in macrophage response in autoimmune disease and defense…”
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MiR-146a rs2910164 G > C polymorphism modulates Notch-1/IL-6 signaling during infection: a possible risk factor for Crohn's disease by Keewan, Esra'a, Naser, Saleh A

“…MiR-146a, an effector mediator, targets Notch-1 and regulates the innate and adaptive immune systems response. Recently, we reported that Notch-1 signaling…”
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Folate and Vitamin B12 Deficiency Exacerbate Inflammation during Mycobacterium avium paratuberculosis (MAP) Infection by Vaccaro, Joseph A., Qasem, Ahmad, Naser, Saleh A.

“…Folate and vitamin B12 deficiency is highly prevalent among Crohn’s disease (CD) patients. Furthermore, CD pathology can be mediated by Mycobacterium avium…”
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Cathelicidin Mediates an Anti-Inflammatory Role of Active Vitamin D (Calcitriol) During M. paratuberculosis Infection by Vaccaro, Joseph A, Qasem, Ahmad, Naser, Saleh A

“…Vitamin D is a key regulator in calcium and phosphorus metabolism which are essential for maintaining bone health. Recent reports also showed a role for…”
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When old metagenomic data meet newly sequenced genomes, a case study by Li, Xin, Naser, Saleh A, Khaled, Annette, Hu, Haiyan, Li, Xiaoman

“…Dozens of computational methods are developed to identify species present in a metagenomic dataset. Many of these computational methods depend on available…”
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Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease by Sharp, Robert C, Abdulrahim, Muna, Naser, Ebraheem S, Naser, Saleh A

“…Genome wide association studies have identified several genes that might be associated with increase susceptibility to Type 1 Diabetes (T1D) and Crohn's…”
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