Search Results - "Naseem, Khalid"

Oxidised Low-Density Lipoprotein-Induced Platelet Hyperactivity—Receptors and Signalling Mechanisms by Berger, Martin, Naseem, Khalid M.

“…Dyslipidaemia leads to proatherogenic oxidative lipid stress that promotes vascular inflammation and thrombosis, the pathologies that underpin myocardial…”
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Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade by Magwenzi, Simbarashe, Woodward, Casey, Wraith, Katie S., Aburima, Ahmed, Raslan, Zaher, Jones, Huw, McNeil, Catriona, Wheatcroft, Stephen, Yuldasheva, Nadira, Febbriao, Maria, Kearney, Mark, Naseem, Khalid M.

“…Oxidized low-density lipoprotein (oxLDL) promotes unregulated platelet activation in dyslipidemic disorders. Although oxLDL stimulates activatory signaling, it…”
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Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets by Aburima, Ahmed, Berger, Martin, Spurgeon, Benjamin E.J., Webb, Bethany A., Wraith, Katie S., Febbraio, Maria, Poole, Alastair W., Naseem, Khalid M.

“…Thrombospondin-1 (TSP-1) is released by platelets upon activation and can increase platelet activation, but its role in hemostasis in vivo is unclear. We show…”
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The role of nitric oxide in cardiovascular diseases by Naseem, Khalid M.

“…Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three distinct isoforms of nitric oxide synthases (NOS), neuronal…”
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cAMP signaling regulates platelet myosin light chain (MLC) phosphorylation and shape change through targeting the RhoA-Rho kinase-MLC phosphatase signaling pathway by Aburima, Ahmed, Wraith, Katie S., Raslan, Zaher, Law, Robert, Magwenzi, Simbarashe, Naseem, Khalid M.

“…Cyclic adenosine monophosphate (cAMP)-dependent signaling modulates platelet shape change through unknown mechanisms. We examined the effects of cAMP signaling…”
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Non-Traditional Pathways for Platelet Pathophysiology in Diabetes: Implications for Future Therapeutic Targets by Sagar, Rebecca C, Ajjan, Ramzi A, Naseem, Khalid M

“…Cardiovascular complications remain the leading cause of morbidity and mortality in individuals with diabetes, driven by interlinked metabolic, inflammatory,…”
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The control of blood platelets by cAMP signalling by Raslan, Zaher, Naseem, Khalid M

“…Blood platelet activation must be tightly regulated to ensure a balance between haemostasis and thrombosis. The cAMP signalling pathway is the most powerful…”
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Oxidized low-density lipoproteins induce rapid platelet activation and shape change through tyrosine kinase and Rho kinase–signaling pathways by Wraith, Katie S., Magwenzi, Simbarashe, Aburima, Ahmed, Wen, Yichuan, Leake, David, Naseem, Khalid M.

“…Oxidized low-density lipoproteins (oxLDL) generated in the hyperlipidemic state may contribute to unregulated platelet activation during thrombosis. Although…”
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Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin: the role of phosphodiesterase 3A by Berger, Martin, Raslan, Zaher, Aburima, Ahmed, Magwenzi, Simbarashe, Wraith, Katie S, Spurgeon, Benjamin E J, Hindle, Matthew S, Law, Robert, Febbraio, Maria, Naseem, Khalid M

“…Prostacyclin (PGI ) controls platelet activation and thrombosis through a cyclic adenosine monophosphate (cAMP) signaling cascade. However, in patients with…”
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Platelet Flow Cytometry: Instrument Setup, Controls, and Panel Performance by Spurgeon, Benjamin E.J., Naseem, Khalid M.

“…Platelet flow cytometry is widely used in cardiovascular medicine as the platelet surface is rich in clinical biomarkers. Surface profiling is critical in…”
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Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade by Roberts, Wayne, Magwenzi, Simbarashe, Aburima, Ahmed, Naseem, Khalid M.

“…Cyclic adenosine monophosphate (cAMP)-dependent signaling modulates platelet function at sites of vascular injury. Here we show that thrombospondin-1 (TSP-1)…”
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Multidimensional flow cytometry reveals novel platelet subpopulations in response to prostacyclin by Hindle, Matthew S., Spurgeon, Benjamin E. J., Cheah, Lih T., Webb, Beth A., Naseem, Khalid M.

“…Background Robust platelet activation leads to the generation of subpopulations characterized by differential expression of phosphatidylserine (PS)…”
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Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor by Crooks, Michael G, Fahim, Ahmed, Naseem, Khalid M, Morice, Alyn H, Hart, Simon P

“…Idiopathic Pulmonary Fibrosis (IPF) is a progressive, incurable fibrotic interstitial lung disease with a prognosis worse than many cancers. Its pathogenesis…”
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Prednisolone exerts exquisite inhibitory properties on platelet functions by Liverani, Elisabetta, Banerjee, Sreemoti, Roberts, Wayne, Naseem, Khalid M., Perretti, Mauro

“…We have previously reported presence of the glucocorticoid (GC) receptor (GR) alpha on blood platelets, and its ability to modulate platelet aggregation when…”
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Coronin 1 Is Required for Integrin β2 Translocation in Platelets by Riley, David R J, Khalil, Jawad S, Pieters, Jean, Naseem, Khalid M, Rivero, Francisco

“…Remodeling of the actin cytoskeleton is one of the critical events that allows platelets to undergo morphological and functional changes in response to…”
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Compartmentalisation of cAMP-dependent signalling in blood platelets: The role of lipid rafts and actin polymerisation by Raslan, Zaher, Naseem, Khalid M.

“…Abstract Prostacyclin (PGI2) inhibits blood platelets through the activation of membrane adenylyl cyclases (ACs) and cyclic adenosine 3',5'-monophosphate…”
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Elimination of fibrin γ-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi by Duval, Cédric, Baranauskas, Adomas, Feller, Tímea, Ali, Majid, Cheah, Lih T., Yuldasheva, Nadira Y., Baker, Stephen R., McPherson, Helen R., Raslan, Zaher, Bailey, Marc A., Cubbon, Richard M., Connell, Simon D., Ajjan, Ramzi A., Philippou, Helen, Naseem, Khalid M., Ridger, Victoria C., Ariëns, Robert A. S.

“…The onset of venous thromboembolism, including pulmonary embolism, represents a significant health burden affecting more than 1 million people annually…”
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A randomised controlled trial to assess the antithrombotic effects of aspirin in type 1 diabetes: role of dosing and glycaemic control by Parker, William A E, Sagar, Rebecca, Kurdee, Zeyad, Hawkins, Fladia, Naseem, Khalid M, Grant, Peter J, Storey, Robert F, Ajjan, Ramzi A

“…The enhanced thrombotic milieu in diabetes contributes to increased risk of vascular events. Aspirin, a key antiplatelet agent, has inconsistent effects on…”
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The Spatiotemporal Regulation of cAMP Signaling in Blood Platelets-Old Friends and New Players by Raslan, Zaher, Aburima, Ahmed, Naseem, Khalid M

“…Atherothrombosis, the pathology underlying numerous cardiovascular diseases, is a major cause of death globally. Hyperactive blood platelets play a key role in…”
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Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications by Kearney, Katherine J., Pechlivani, Nikoletta, King, Rhodri, Tiede, Christian, Phoenix, Fladia, Cheah, Ramsah, Macrae, Fraser L., Simmons, Katie J., Manfield, Iain W., Smith, Kerrie A., Spurgeon, Benjamin E.J., Naseem, Khalid M., Ariens, Robert A.S., McPherson, Michael J., Tomlinson, Darren C., Ajjan, Ramzi A.

“…Bleeding complications secondary to surgery, trauma, or coagulation disorders are important causes of morbidity and mortality. Although fibrin sealants are…”
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