Search Results - "Nascimento, Nilberto R. F"
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Incorporation of Nitroprusside on Silica NanoparticlesA Strategy for Safer Use of This NO Donor in Therapy
Published in Molecular pharmaceutics (01-07-2019)“…Silica-based nanoparticles have been developed as powerful platforms for drug delivery and might also prevent undesired side effects of drugs. Here, a fast…”
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Post-weaning Exposure to High-Fat Diet Induces Kidney Lipid Accumulation and Function Impairment in Adult Rats
Published in Frontiers in nutrition (Lausanne) (03-05-2019)“…We investigated the kidney morphofunctional consequences of high-fat diet intake since post-weaning in adult rats. Male Wistar rats were divided into two…”
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Anthelmintic effect of Eucalyptus staigeriana essential oil against goat gastrointestinal nematodes
Published in Veterinary parasitology (11-10-2010)“…The aim of this study was to evaluate the anthelmintic efficacy of Eucalyptus staigeriana essential oil (EsEO). The in vitro effects of EsEO were determined…”
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Non-nitric oxide based metallovasodilators: synthesis, reactivity and biological studies
Published in Dalton transactions : an international journal of inorganic chemistry (14-08-2015)“…There is an increasing number of compounds developed to target one or more pathways involved in vasodilation. Some studies conducted with azaindole and…”
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Role of Src Family Kinase in Extracellular Renal Cyclic Guanosine 3′,5′-Monophosphate- and Pressure-Induced Natriuresis
Published in Hypertension (Dallas, Tex. 1979) (01-07-2011)“…cGMP functions as an extracellular (paracrine) messenger acting at the renal proximal tubule and is an important modulator of pressure-natriuresis (P-N). The…”
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A new structurally atypical bradykinin-potentiating peptide isolated from Crotalus durissus cascavella venom (South American rattlesnake)
Published in Toxicon (Oxford) (01-11-2014)“…Venom glands of some snakes synthesize bradykinin-potentiating peptides (BPP's) which increase bradykinin-induced hypotensive effect and decrease angiotensin I…”
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Renal and vascular effects of the natriuretic peptide isolated from Crotalus durissus cascavella venom
Published in Toxicon (Oxford) (01-12-2008)“…Crotalus durissus cascavella is a snake that is usually found in the scrublands of northeast Brazil. The components of its venom may have effects on the…”
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Anti-bacterial, anti-biofilm and synergistic effects of phenazine-based ruthenium(II) complexes
Published in Dalton transactions : an international journal of inorganic chemistry (30-07-2024)“…Antimicrobial resistance has become a global threat to human health, which is coupled with the lack of novel drugs. Metallocompounds have emerged as promising…”
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PKB is a central molecule in the modulation of Na+-ATPase activity by albumin in renal proximal tubule cells
Published in Archives of biochemistry and biophysics (15-10-2019)“…Evidence points to a possible role of tubular sodium reabsorption in worsening renal injury. Proximal tubule (PT) albumin overload is a critical process in the…”
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Role of phospholipase A2 and tyrosine kinase in Clostridium difficile toxin A-induced disruption of epithelial integrity, histologic inflammatory damage and intestinal secretion
Published in Journal of applied toxicology (01-10-2008)“…Clostridium difficile‐associated disease causes diarrhea to fulminant colitis and death. We investigated the role of phospholipase A2 (PLA2) inhibitors,…”
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Thiocarbonyl-bound metallonitrosyl complexes with visible-light induced DNA cleavage and promising vasodilation activity
Published in Journal of inorganic biochemistry (01-05-2018)“…Nitric oxide has been involved in many key biological processes such as vasodilation, platelet aggregation, apoptosis, memory function, and this has drawn…”
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12
Relaxation of rabbit corpus cavernosum smooth muscle and aortic vascular endothelium induced by new nitric oxide donor substances of the nitrosyl-ruthenium complex
Published in International Brazilian journal of urology (01-10-2008)“…Endothelial dysfunction characterized by endogenous nitric oxide (NO) deficiency made 56% of patients affected with erectile dysfunction decline treatment with…”
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Uroguanylin modulates (Na++K+)ATPase in a proximal tubule cell line: Interactions among the cGMP/protein kinase G, cAMP/protein kinase A, and mTOR pathways
Published in Biochimica et biophysica acta (01-07-2016)“…The natriuretic effect of uroguanylin (UGN) involves reduction of proximal tubule (PT) sodium reabsorption. However, the target sodium transporters as well as…”
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Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission
Published in Fitoterapia (01-06-2020)“…The new glucosyl sarpagan alkaloid designated as 21(R*)-(O-β-glucosyl)-hydroxy-sarpagan-17-oic acid, along with eleven known alkaloids were isolated from a…”
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Effects of cardiotonic steroids on isolated perfused kidney and NHE3 activity in renal proximal tubules
Published in Biochimica et biophysica acta. General subjects (01-08-2017)“…Cardiotonic steroids (CS) are known as modulators of sodium and water homeostasis. These compounds contribute to the excretion of sodium under overload…”
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Terpinen-4-ol inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents
Published in Future microbiology (01-09-2019)“…This study investigated the effect of terpinen-4-ol against complex and its interactions with antifungals. The antifungal activity of terpinen-4-ol was…”
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Terpinen-4-ol: mechanisms of relaxation on rabbit duodenum
Published in Journal of pharmacy and pharmacology (01-04-2005)“…The effect of terpinen‐4‐ol was studied on rabbit duodenum in‐vitro. Terpinen‐4‐ol induced relaxation of the basal tonus (IC50 170.2 (95% confidence interval,…”
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Isolation, homology modeling and renal effects of a C-type natriuretic peptide from the venom of the Brazilian yellow scorpion (Tityus serrulatus)
Published in Toxicon (Oxford) (01-11-2013)“…Mammalian natriuretic peptides (NPs) have been extensively investigated for use as therapeutic agents in the treatment of cardiovascular diseases. Here, we…”
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Natriuretic effect of bufalin in isolated rat kidneys involves activation of the Na+-K+-ATPase-Src kinase pathway
Published in American journal of physiology. Renal physiology (15-04-2012)“…Bufadienolides are structurally related to the clinically relevant cardenolides (e.g., digoxin) and are now considered as endogenous steroid hormones. Binding…”
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The Relaxation Induced by Uroguanylin and the Expression of Natriuretic Peptide Receptors in Human Corpora Cavernosa
Published in Journal of sexual medicine (01-11-2010)“…Receptors for natriuretic peptides have been demonstrated as potential targets for the treatment of male erectile dysfunction. This study investigates the…”
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