Supramolecular polyelectrolyte complexes based on cyclodextrin-grafted chitosan and carrageenan for controlled drug release

[Display omitted] •Supramolecular polyelectrolyte complex between βCD-CS and CRG were prepared.•Silver sulfadiazine was incorporated to the polyelectrolyte complex.•The contact between silver sulfadiazine and βCD-CS/CRG produces silver nanostructures.•Semiempirical molecular modeling studies suggest...

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Bibliographic Details
Published in:	Carbohydrate polymers Vol. 245; p. 116592
Main Authors:	Evangelista, Thamasia F.S., Andrade, George R.S., Nascimento, Keyte N.S., dos Santos, Samuel B., de Fátima Costa Santos, Maria, Da Ros Montes D'Oca, Caroline, dos S. Estevam, Charles, Gimenez, Iara F., Almeida, Luís E.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-10-2020
Subjects:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Biopolymers Carrageenan - chemistry Chitosan - chemistry Computational Biology - methods Controlled drug release Cyclodextrins - chemistry Drug Liberation - drug effects Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Ions - chemistry Microbial Sensitivity Tests Nanostructures - chemistry Polyelectrolytes - chemistry Polyelectrolytes - pharmacology Silver - chemistry Silver nanostructures Silver sulfadiazine Silver Sulfadiazine - chemistry Silver Sulfadiazine - pharmacology Supramolecular polyelectrolyte complexes FTIR-ATR GTM DRS SSD MIC XRD Biopolymers SPECs Silver sulfadiazine CS Silver nanostructures Supramolecular polyelectrolyte complexes NMR Controlled drug release SPR ZOI PM3 CRG LDRS v/v TEM wt βCD
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Summary:	[Display omitted] •Supramolecular polyelectrolyte complex between βCD-CS and CRG were prepared.•Silver sulfadiazine was incorporated to the polyelectrolyte complex.•The contact between silver sulfadiazine and βCD-CS/CRG produces silver nanostructures.•Semiempirical molecular modeling studies suggest the host/guest complex formation.•βCD-CS/CRG-SSD showed a clean antibacterial activity toward various bacterial strains. In the present study, supramolecular polyelectrolyte complexes (SPEC) based on a cyclodextrin-grafted chitosan derivative and carrageenan were prepared and evaluated for controlled drug release. Samples were characterized by FTIR, SEM, and ζ-potential measurements, which confirmed the formation of the polymeric complex. The phenolphthalein test confirmed the presence and availability of inclusion sites from the attached βCD. Silver sulfadiazine was used as the model drug and the association with the SPEC was studied by FTIR and computational molecular modeling, using a semi-empirical method. DRS and TEM analyses have shown that Ag+ ions from the drug were reduced to form metallic silver nanostructures. In vitro tests have shown a clear bacterial activity toward Gram-positive bacteria Staphylococcus aureus and Enterococcus durans/hirae and Gram-negative bacteria Klebsiella pneumoniae and Escherichia coli. Finally, this work shows that βCD-chitosan/carrageenan supramolecular polyelectrolyte complexes hold an expressive potential to be applied as a polymer-based system for controlled drug release.
ISSN:	0144-8617 1879-1344
DOI:	10.1016/j.carbpol.2020.116592