Effects of Coffee on Sirtuin-1, Homocysteine, and Cholesterol of Healthy Adults: Does the Coffee Powder Matter?

Effects of Coffee on Sirtuin-1, Homocysteine, and Cholesterol of Healthy Adults: Does the Coffee Powder Matter?

Background: Coffee is one of the most popular beverages globally and contains several bioactive compounds that are relevant to human health. Many nutritional strategies modulate sirtuin-1, thereby impacting aging and cardiometabolic health. This study investigated the influence of different blended...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical medicine Vol. 11; no. 11; p. 2985
Main Authors: Gonçalinho, Gustavo Henrique Ferreira, Nascimento, José Rafael de Oliveira, Mioto, Bruno Mahler, Amato, Reynaldo Vicente, Moretti, Miguel Antonio, Strunz, Célia Maria Cassaro, César, Luiz Antonio Machado, Mansur, Antonio de Padua
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 25-05-2022
MDPI
Subjects:
Caffeine
Cardiovascular disease
Cholesterol
Clinical medicine
Coffee industry
Diabetes
DNA repair
Gene expression
Glucose
High density lipoprotein
Homeostasis
Homocysteine
Hormone replacement therapy
Hypertension
Insulin resistance
Intervention
Life expectancy
Lipids
Metabolism
Metabolites
Triglycerides
Brazil
United States > US
homocysteine
Robusta
sirtuin-1
Arabica
coffee
bioactive compounds
cholesterol
cardiometabolic health
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Coffee is one of the most popular beverages globally and contains several bioactive compounds that are relevant to human health. Many nutritional strategies modulate sirtuin-1, thereby impacting aging and cardiometabolic health. This study investigated the influence of different blended coffees on serum sirtuin-1, blood lipids, and plasma homocysteine. Methods: An eight-week randomized clinical trial that included 53 healthy adults of both sexes analyzed the effects of daily intake of 450 to 600 mL of pure Arabica or blended (Arabica + Robusta) coffee intake of filtered coffee on blood sirtuin-1, lipids, and homocysteine. Results: Both Arabica and blended coffees similarly increased serum sirtuin-1 concentration, from 0.51 to 0.58 ng/mL (p = 0.004) and from 0.40 to 0.49 ng/mL (p = 0.003), respectively, without changing plasma homocysteine, folic acid, glucose, and CRP. However, the blended coffee intake increased total cholesterol from 4.70 to 5.17 mmol/L (p < 0.001) and LDL-cholesterol from 2.98 to 3.32 mmol/L (p < 0.001), as well as HDL-c from 1.26 to 1.36 mmol/L (p < 0.001). Conclusion: Both coffee powders increased sirtuin-1 expression, but our results suggest that blended coffee had hypercholesterolemic effects which could increase cardiovascular risk. Therefore, preference should be given to Arabica coffee for the best cardiometabolic benefits of coffee.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11112985