Search Results - "Nascimento, José Luiz Martins do"
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Mercury: What can we learn from the Amazon?
Published in Environment international (01-01-2021)“…•Approximately 80% of mercury emissions in South America is from the Amazon.•Biomass burning in the last two years will likely increase mercury exposure…”
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Microenvironment of Mycobacterium smegmatis Culture to Induce Cholesterol Consumption Does Cell Wall Remodeling and Enables the Formation of Granuloma-Like Structures
Published in BioMed research international (01-01-2019)“…Pathogenic species of mycobacteria are known to use the host cholesterol during lung infection as an alternative source of carbon and energy. Mycobacteria…”
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Inhibition of Melanization by Kojic Acid Promotes Cell Wall Disruption of the Human Pathogenic Fungus Fonsecaea sp
Published in Pathogens (Basel) (17-08-2022)“…Chromoblastomycosis (CBM) is a chronic human subcutaneous mycosis caused by various aetiologic agents. CBM does not have an established treatment but may be…”
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Global Human Threat: The Potential Synergism between Mercury Intoxication and COVID-19
Published in International journal of environmental research and public health (27-02-2023)“…The COVID-19 pandemic affected billions of people worldwide, and exposure to toxic metals has emerged as an important risk factor for COVID-19 severity…”
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The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils?
Published in Molecules (Basel, Switzerland) (04-06-2022)“…Seizures and epilepsy are some of the most common serious neurological disorders, with approximately 80% of patients living in developing/underdeveloped…”
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In Vitro Cytotoxic Effects and Mechanisms of Action of Eleutherine Isolated from Eleutherine plicata Bulb in Rat Glioma C6 Cells
Published in Molecules (Basel, Switzerland) (13-12-2022)“…Gliomas are the most common primary malignant brain tumors in adults, and have a poor prognosis, despite the different types of treatment available. There is…”
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Fatty Acid Amides Suppress Proliferation via Cannabinoid Receptors and Promote the Apoptosis of C6 Glioma Cells in Association with Akt Signaling Pathway Inhibition
Published in Pharmaceuticals (Basel, Switzerland) (02-07-2024)“…A glioma is a type of tumor that acts on the Central Nervous System (CNS) in a highly aggressive manner. Gliomas can occasionally be inaccurately diagnosed and…”
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Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí ( Euterpe oleracea , Mart.) as Juice for Human Consumption
Published in Nutrients (26-10-2019)“…Methylmercury (MeHg) exposure is a serious problem of public health, especially in the Amazon. Exposure in riverine populations is responsible for…”
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In the Heart of the Amazon: Noncommunicable Diseases and Apolipoprotein E4 Genotype in the Riverine Population
Published in International journal of environmental research and public health (07-09-2018)“…The Amazon River basin is the largest tropical forest in the world. Most of the Amazon belongs to Brazil, a developing country that currently faces huge…”
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Combined Kinetic Studies and Computational Analysis on Kojic Acid Analogs as Tyrosinase Inhibitors
Published in Molecules (Basel, Switzerland) (01-07-2014)“…Tyrosinase is a key enzyme in melanin synthesis and widely distributed in plants and animals tissues. In mammals, this enzyme is related to pigment production,…”
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Scopolamine- and diazepam-induced amnesia are blocked by systemic and intraseptal administration of substance P and choline chloride
Published in Peptides (New York, N.Y. : 1980) (01-09-2010)“…▶ This study investigates interactions between cholinergic and GABA/benzodiazepine systems with the substance P system on inhibitory avoidance retention in…”
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Fatty Acid Amides Synthesized from Andiroba Oil ( Carapa guianensis Aublet.) Exhibit Anticonvulsant Action with Modulation on GABA-A Receptor in Mice: A Putative Therapeutic Option
Published in Pharmaceuticals (Basel, Switzerland) (10-03-2020)“…Epilepsy is a chronic neurological disease characterized by excessive neuronal activity leading to seizure; about 30% of affected patients suffer from the…”
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Regulation of the Serotonergic System by Kainate in the Avian Retina
Published in Cellular and molecular neurobiology (01-10-2019)“…Serotonin (5-HT) has been recognized as a neurotransmitter in the vertebrate retina, restricted mainly to amacrine and bipolar cells. It is involved with…”
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Culture of Mycobacterium smegmatis in Different Carbon Sources to Induce In Vitro Cholesterol Consumption Leads to Alterations in the Host Cells after Infection: A Macrophage Proteomics Analysis
Published in Pathogens (Basel) (28-05-2021)“…During tuberculosis, Mycobacterium uses host macrophage cholesterol as a carbon and energy source. To mimic these conditions, Mycobacterium smegmatis can be…”
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Chickens treated with a nitric oxide inhibitor became more resistant to Plasmodium gallinaceum infection due to reduced anemia, thrombocytopenia and inflammation
Published in Veterinary research (Paris) (11-02-2013)“…Malaria is a serious infectious disease caused by parasites of the Plasmodium genus that affect different vertebrate hosts. Severe malaria leads to host death…”
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Methylmercury genotoxicity: A novel effect in human cell lines of the central nervous system
Published in Environment international (01-02-2007)“…Methylmercury is an important source of environmental contamination and the central nervous system (CNS) is one of the main target organs. Methylmercury…”
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Libidibia ferrea Mature Seeds Promote Antinociceptive Effect by Peripheral and Central Pathway : Possible Involvement of Opioid and Cholinergic Receptors
Published in BioMed research international (01-01-2014)“…Libidibia ferrea (LF) is a medicinal plant that holds many pharmacological properties. We evaluated the antinociceptive effect in the LF aqueous seed extract…”
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In vitro immunomodulatory effects of Caryocar villosum oil on murine macrophages
Published in Biomedicine & pharmacotherapy (01-10-2024)“…Macrophages undergo activation in response to multiple stimuli, including pathogens, growth factors and natural products. The inflammatory response and…”
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Assessing mercury intoxication in isolated/remote populations: Increased S100B mRNA in blood in exposed riverine inhabitants of the Amazon
Published in Neurotoxicology (Park Forest South) (01-09-2018)“…[Display omitted] •Circulating S100B protein was proposed as a biomarker of MeHg-related neurotoxicity.•We quantified blood mRNA as alternative to protein in…”
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GABA and glutamate transporters: new events and function in the vertebrate retina
Published in Psychology & Neuroscience (2013)“…The neural retina is a highly complex tissue composed of excitatory and inhibitory neurons and glial cells. Glutamate, the main excitatory neurotransmitter,…”
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