Protective effect against gastric mucosa injury of a sulfated agaran from Acanthophora spicifera

[Display omitted] •Polysaccharide from Acanthophora spicifera (PAs) is an agar-type polysaccharide.•PAs possesses a high sulfate content.•PAs reduces the oxidative stress and enhances defense mechanisms of the gastric mucosa. In this study, a polysaccharide from marine alga Acanthophora spicifera (P...

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Bibliographic Details
Published in:	Carbohydrate polymers Vol. 261; p. 117829
Main Authors:	Pereira Júnior, Lindauro C., Nascimento, Fernando G., Oliveira, Samara R.B.D., Lima, Glauber C., Chagas, Francisco Diego S., Sombra, Venicios G., Feitosa, Judith P.A., Soriano, Eliane M., Souza, Marcellus H.L.P., Zocolo, Guilherme J., Silva, Lorena M.A., de Paula, Regina C.M., Damasceno, Renan O.S., Freitas, Ana Lúcia P.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-06-2021
Subjects:	A. spicifera Agar - isolation & purification Agar - pharmacology Animals Cytoprotection - drug effects Gastric injury Gastric Mucosa - drug effects Gastric Mucosa - injuries Gastric Mucosa - pathology Male Mice Oxidative stress Oxidative Stress - drug effects Polysaccharide Polysaccharides - chemistry Polysaccharides - isolation & purification Polysaccharides - pharmacology Rhodophyta - chemistry Rhodophyta - metabolism Stomach - drug effects Stomach - injuries Stomach - pathology Stomach Ulcer - pathology Stomach Ulcer - prevention & control Sulfates - chemistry Sulfates - pharmacology Oxidative stress NMR Gastric injury A. spicifera FTIR ROS Hb GPC MDA GSH Polysaccharide GPx
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Summary:	[Display omitted] •Polysaccharide from Acanthophora spicifera (PAs) is an agar-type polysaccharide.•PAs possesses a high sulfate content.•PAs reduces the oxidative stress and enhances defense mechanisms of the gastric mucosa. In this study, a polysaccharide from marine alga Acanthophora spicifera (PAs) was isolated and structurally characterized. Its protective potential against chemically-induced gastric mucosa injury was evaluated. The gel permeation chromatography experiments and spectroscopy spectrum showed that PAs is a sulfated polysaccharide with a high molecular mass (6.98 × 105g/mol) and degree of sulfation of 1.23, exhibiting structural characteristic typical of an agar-type polysaccharide. Experimental results demonstrated that PAs reduced the hemorrhagic gastric injury, in a dose-dependent manner. Additionally, PAs reduced the intense gastric oxidative stress, measured by glutathione (GSH) and malondialdehyde (MDA) levels. PAs also prevented the reduction of mucus levels adhered to the gastric mucosa, promoted by the aggressive effect of ethanol. In summary, the sulfated polysaccharide from A. spicifera protected the gastric mucosa through the prevention of lipid peroxidation and enhanced the defense mechanisms of the gastric mucosa, suggesting as a promising functional food as gastroprotective agent.
ISSN:	0144-8617 1879-1344
DOI:	10.1016/j.carbpol.2021.117829