Search Results - "Nascimento, Emmani B M"

PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans by de Wit-Verheggen, Vera H. W., Schrauwen-Hinderling, Vera B., Brouwers, Kim, Jörgensen, Johanna A., Schaart, Gert, Gemmink, Anne, Nascimento, Emmani B. M., Hesselink, Matthijs K. C., Wildberger, Joachim E., Segers, Patrique, Montaigne, David, Staels, Bart, Schrauwen, Patrick, Lindeboom, Lucas, Hoeks, Joris, van de Weijer, Tineke

“…Cardiac energy status, measured as phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio with 31P-Magnetic Resonance Spectroscopy (31P-MRS) in vivo, is a…”
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Metabolic responses to mild cold acclimation in type 2 diabetes patients by Remie, Carlijn M. E., Moonen, Michiel P. B., Roumans, Kay H. M., Nascimento, Emmani B. M., Gemmink, Anne, Havekes, Bas, Schaart, Gert, Kornips, Esther, Joris, Peter J., Schrauwen-Hinderling, Vera B., Hoeks, Joris, Kersten, Sander, Hesselink, Matthijs K. C., Phielix, Esther, Lichtenbelt, Wouter D. van Marken, Schrauwen, Patrick

“…Mild cold acclimation for 10 days has been previously shown to markedly improve insulin sensitivity in patients with type 2 diabetes. Here we show in a…”
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[18F]BODIPY-triglyceride-containing chylomicron-like particles as an imaging agent for brown adipose tissue in vivo by Paulus, Andreas, Drude, Natascha, Nascimento, Emmani B. M., Buhl, Eva M., Berbée, Jimmy F. P., Rensen, Patrick C. N., van Marken Lichtenbelt, Wouter D., Mottaghy, Felix M., Bauwens, Matthias

“…Brown adipose tissue (BAT) is present in human adults and the current gold standard to visualize and quantify BAT is [ 18 F]FDG PET-CT. However, this method…”
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Characterization of BAT activity in rats using invasive and non-invasive techniques by Paulus, Andreas, van Ewijk, Petronella A, Nascimento, Emmani B M, De Saint-Hubert, Marijke, Hendrikx, Geert, Vogg, Andrea, Pooters, Ivo, Schnijderberg, Melanie, Vanderlocht, Joris, Bos, Gerard, Brans, Boudewijn, Schrauwen-Hinderling, Vera B, Mottaghy, Felix M, Bauwens, Matthias

“…Brown adipose tissue (BAT) is considered as a potential target for combating obesity in humans where active BAT metabolizes glucose and fatty acids as fuel…”
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Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers by Nascimento, Emmani B M, Hangelbroek, Roland W J, Hooiveld, Guido J E J, Hoeks, Joris, Van Marken Lichtenbelt, Wouter D, Hesselink, Matthijs H C, Schrauwen, Patrick, Kersten, Sander

“…Cold acclimation and exercise training were previously shown to increase peripheral insulin sensitivity in human volunteers with type 2 diabetes. Although cold…”
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Synthesis, radiosynthesis and in vitro evaluation of 18F-Bodipy-C16/triglyceride as a dual modal imaging agent for brown adipose tissue by Paulus, Andreas, Maenen, Marco, Drude, Natascha, Nascimento, Emmani B M, van Marken Lichtenbelt, Wouter D, Mottaghy, Felix M, Bauwens, Matthias

“…Brown adipose tissue research is in the focus in the field of endocrinology. We designed a dual-modal fluorescent/PET fatty acid based tracer on commercially…”
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Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice[S] by Mannerås-Holm, Louise, Schönke, Milena, Brozinick, Joseph T., Vetterli, Laurène, Bui, Hai-Hoang, Sanders, Philip, Nascimento, Emmani B.M., Björnholm, Marie, Chibalin, Alexander V., Zierath, Juleen R.

“…Diacylglycerol kinases (DGKs) catalyze the phosphorylation and conversion of diacylglycerol (DAG) into phosphatidic acid. DGK isozymes have unique primary…”
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Role of PRAS40 in Akt and mTOR signaling in health and disease by Wiza, Claudia, Nascimento, Emmani B M, Ouwens, D Margriet

“…The proline-rich Akt substrate of 40 kDa (PRAS40) acts at the intersection of the Akt- and mammalian target of rapamycin (mTOR)-mediated signaling pathways…”
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Nicotinamide Riboside Enhances In Vitro Beta-adrenergic Brown Adipose Tissue Activity in Humans by Nascimento, Emmani B M, Moonen, Michiel P B, Remie, Carlijn M E, Gariani, Karim, Jörgensen, Johanna A, Schaart, Gert, Hoeks, Joris, Auwerx, Johan, van Marken Lichtenbelt, Wouter D, Schrauwen, Patrick

“…Abstract Context Elevating nicotinamide adenine dinucleotide (NAD+) levels systemically improves metabolic health, which can be accomplished via nicotinamide…”
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Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes by Clemmensen, Christoffer, Jall, Sigrid, Kleinert, Maximilian, Quarta, Carmelo, Gruber, Tim, Reber, Josefine, Sachs, Stephan, Fischer, Katrin, Feuchtinger, Annette, Karlas, Angelos, Simonds, Stephanie E., Grandl, Gerald, Loher, Daniela, Sanchez-Quant, Eva, Keipert, Susanne, Jastroch, Martin, Hofmann, Susanna M., Nascimento, Emmani B. M., Schrauwen, Patrick, Ntziachristos, Vasilis, Cowley, Michael A., Finan, Brian, Müller, Timo D., Tschöp, Matthias H.

“…Pharmacological stimulation of brown adipose tissue (BAT) thermogenesis to increase energy expenditure is progressively being pursued as a viable anti-obesity…”
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In vitro effects of sitosterol and sitostanol on mitochondrial respiration in human brown adipocytes, myotubes and hepatocytes by Nascimento, Emmani B. M., Konings, Maurice, Schaart, Gert, Groen, Albert K., Lütjohann, Dieter, van Marken Lichtenbelt, Wouter D., Schrauwen, Patrick, Plat, Jogchum

“…Purpose Lowering of LDL cholesterol levels by plant sterols and stanols is associated with decreased risk of cardiovascular disease in humans. Plant sterols…”
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ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity by Sparks, Lauren M., Gemmink, Anne, Phielix, Esther, Bosma, Madeleen, Schaart, Gert, Moonen-Kornips, Esther, Jörgensen, Johanna A., Nascimento, Emmani B. M., Hesselink, Matthijs K. C., Schrauwen, Patrick, Hoeks, Joris

“…Aims/hypothesis Dissipating energy via mitochondrial uncoupling has been suggested to contribute to enhanced insulin sensitivity. We hypothesised that skeletal…”
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Diacylglycerol kinase α deficiency alters inflammation markers in adipose tissue in response to a high-fat diet by Nascimento, Emmani B.M., Mannerås-Holm, Louise, Chibalin, Alexander V., Björnholm, Marie, Zierath, Juleen R.

“…Conversion of diacylglycerol to phosphatidic acid is mediated by diacylglycerol kinases (DGKs), with DGKα specifically linked to adaptive immune responses. We…”
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Publisher Correction: Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes by Clemmensen, Christoffer, Jall, Sigrid, Kleinert, Maximilian, Quarta, Carmelo, Gruber, Tim, Reber, Josefine, Sachs, Stephan, Fischer, Katrin, Feuchtinger, Annette, Karlas, Angelos, Simonds, Stephanie E., Grandl, Gerald, Loher, Daniela, Sanchez-Quant, Eva, Keipert, Susanne, Jastroch, Martin, Hofmann, Susanna M., Nascimento, Emmani B. M., Schrauwen, Patrick, Ntziachristos, Vasilis, Cowley, Michael A., Finan, Brian, Müller, Timo D., Tschöp, Matthias H.

“…In the original PDF version of this article, affiliation 1, ‘Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen &…”
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Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1 by Nascimento, Emmani B.M., Snel, Marieke, Guigas, Bruno, van der Zon, Gerard C.M., Kriek, Jan, Maassen, J. Antonie, Jazet, Ingrid M., Diamant, Michaela, Ouwens, D. Margriet

“…Type 2 diabetes is associated with alterations in protein kinase B (PKB/Akt) and mammalian target of rapamycin complex 1 (mTORC1) signalling. The proline-rich…”
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The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity by Broeders, Evie P.M., Nascimento, Emmani B.M., Havekes, Bas, Brans, Boudewijn, Roumans, Kay H.M., Tailleux, Anne, Schaart, Gert, Kouach, Mostafa, Charton, Julie, Deprez, Benoit, Bouvy, Nicole D., Mottaghy, Felix, Staels, Bart, van Marken Lichtenbelt, Wouter D., Schrauwen, Patrick

“…The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In…”
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Human brown adipose tissue: Underestimated target in metabolic disease? by Moonen, Michiel P.B., Nascimento, Emmani B.M., van Marken Lichtenbelt, Wouter D.

“…Active brown adipose tissue (BAT) has, since it rediscovery in adult humans in 2009, received much attention for its ability to increase energy expenditure…”
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MicroRNA‐204‐5p modulates mitochondrial biogenesis in C2C12 myotubes and associates with oxidative capacity in humans by Houzelle, Alexandre, Dahlmans, Dennis, Nascimento, Emmani B. M., Schaart, Gert, Jörgensen, Johanna A., Moonen‐Kornips, Esther, Kersten, Sander, Wang, Xu, Hoeks, Joris

“…Using an unbiased high‐throughput microRNA (miRNA)‐silencing screen combined with functional readouts for mitochondrial oxidative capacity in C2C12 myocytes,…”
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Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet–Fed Rats by NASCIMENTO, Emmani B. M, FODOR, Mariann, DIAMANT, Michaela, MARGRIET OUWENS, D, VAN DER ZON, Gerard C. M, JAZET, Ingrid M, EDO MEINDERS, A, VOSHOL, Peter J, VLASBLOM, Ronald, BAAN, Bart, ECKEL, Jurgen, ANTONIE MAASSEN, J

“…Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet–Fed Rats Emmani B.M…”
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4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue by Grandoch, Maria, Flögel, Ulrich, Virtue, Sam, Maier, Julia K., Jelenik, Tomas, Kohlmorgen, Christina, Feldmann, Kathrin, Ostendorf, Yanina, Castañeda, Tamara R., Zhou, Zhou, Yamaguchi, Yu, Nascimento, Emmani B. M., Sunkari, Vivekananda G., Goy, Christine, Kinzig, Martina, Sörgel, Fritz, Bollyky, Paul L., Schrauwen, Patrick, Al-Hasani, Hadi, Roden, Michael, Keipert, Susanne, Vidal-Puig, Antonio, Jastroch, Martin, Haendeler, Judith, Fischer, Jens W.

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