Search Results - "Nascimento, Claudia Jorge do"
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A new guanylhydrazone derivative as a potential acetylcholinesterase inhibitor for Alzheimer's disease: synthesis, molecular docking, biological evaluation and kinetic studies by nuclear magnetic resonance
Published in RSC advances (2017)“…The development of pharmacological agents for the treatment of Alzheimer's Disease (AD) is very relevant since this is the most common type of dementia. The…”
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Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry
Published in Nature communications (01-03-2018)“…Although drug development typically focuses on binding thermodynamics, recent studies suggest that kinetic properties can strongly impact a drug candidate’s…”
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The 1H, 15N, and 13C resonance assignments of a single-domain antibody against immunoglobulin G
Published in Biomolecular NMR assignments (01-12-2024)“…Research on camelid-derived single-domain antibodies (sdAbs) has demonstrated their significant utility in diverse biotechnological applications, including…”
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New semicarbazones as gorge-spanning ligands of acetylcholinesterase and potential new drugs against Alzheimer's disease: Synthesis, molecular modeling, NMR, and biological evaluation
Published in Journal of biomolecular structure & dynamics (18-11-2018)“…Two new compounds (E)-2-(5,7-dibromo-3,3-dimethyl-3,4-dihydroacridin-1(2H)-ylidene)hydrazinecarbothiomide (3) and…”
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Nuclear Magnetic Resonance (NMR), Infrared (IR) and Mass Spectrometry (MS) study of keto-enol tautomerism of isobenzofuran-1(3H)-one derivatives
Published in Journal of molecular structure (05-06-2016)“…The keto-enol tautomerism of 3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohexen-1-yl)isobenzofuran-1(3H-one (1),…”
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Design, synthesis, docking studies and bioactivity evaluation of 1,2,3-triazole eugenol derivatives
Published in Future medicinal chemistry (16-09-2024)“…The design, synthesis, docking studies and evaluation of the antifungal and cytotoxic properties of eugenol (EUG) containing 1,2,3-triazole derivatives are…”
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The 1 H, 15 N, and 13 C resonance assignments of a single-domain antibody against immunoglobulin G
Published in Biomolecular NMR assignments (13-09-2024)“…Research on camelid-derived single-domain antibodies (sdAbs) has demonstrated their significant utility in diverse biotechnological applications, including…”
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Some Mechanistic Aspects on Fmoc Solid Phase Peptide Synthesis
Published in International journal of peptide research and therapeutics (01-03-2014)“…Peptides are biomolecules that may have several biological activities which makes them important to the environment in which they operate. Sometimes it is…”
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SÍNTESE DE NOVOS 1,2,3-TRIAZÓIS INSPIRADOS NO SRPIN340 E AVALIAÇÃO DE SEUS EFEITOS EM LINHAGEM CELULAR DE GLIOBLASTOMA HUMANO
Published in Química Nova (01-12-2021)Get full text
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A new guanylhydrazone derivative as a potential acetylcholinesterase inhibitor for Alzheimer's disease: synthesis, molecular docking, biological evaluation and kinetic studies by nuclear magnetic resonanceElectronic supplementary information (ESI) available: Additional figures, tables, graphs, IR and NMR spectra are available for a better illustration and comprehension of the results. See DOI: 10.1039/c7ra04180b
Published 05-07-2017“…The development of pharmacological agents for the treatment of Alzheimer's Disease (AD) is very relevant since this is the most common type of dementia. The…”
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SHESSLOC: A selective variation of the FUCOUP sequence
Published in Journal of magnetic resonance (1997) (01-07-2007)“…In this paper we carried out a comparison between all the possible selective versions of the basic heteronuclear correlation experiment, the FUCOUP sequence…”
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