A Comprehensive Investigation of the Potential Role of Lipoproteins and Metabolite Profile as Biomarkers of Alzheimer’s Disease Compared to the Known CSF Biomarkers

A Comprehensive Investigation of the Potential Role of Lipoproteins and Metabolite Profile as Biomarkers of Alzheimer’s Disease Compared to the Known CSF Biomarkers

Introduction. While cerebrospinal fluid (CSF) core biomarkers have been considered diagnostic biomarkers for a long time, special attention has been recently dedicated to lipoproteins and metabolites that could be potentially associated with Alzheimer’s disease (AD) neurodegeneration. Herein, we aim...

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Published in:International journal of alzheimer's disease Vol. 2023; pp. 3540020 - 9
Main Authors: Nasab, Azam Sajjadi, Noorani, Fatemeh, Paeizi, Zahra, Khani, Leila, Banaei, Saba, Sadeghi, Mohammad, Shafeghat, Melika, Shafie, Mahan, Mayeli, Mahsa, Initiative (ADNI), The Alzheimer's Disease Neuroimaging
Format: Journal Article
Language:English
Published: United States Hindawi 09-03-2023
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Advertising executives
Alzheimer's disease
Amino acids
Biological markers
Biomarkers
Blood lipids
Cerebrospinal fluid
Cognitive ability
Correlation
Development and progression
E protein
Fatty acids
Glycerol
Glycolysis
High density lipoprotein
Investigations
Ketones
Leucine
Lipid metabolism
Lipids
Lipoproteins
Lipoproteins (very low density)
Medical imaging
Metabolites
Neurodegenerative diseases
Neuroimaging
Phenylalanine
Tau protein
Unsaturated fatty acids
United States > US
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Summary:Introduction. While cerebrospinal fluid (CSF) core biomarkers have been considered diagnostic biomarkers for a long time, special attention has been recently dedicated to lipoproteins and metabolites that could be potentially associated with Alzheimer’s disease (AD) neurodegeneration. Herein, we aimed to investigate the relationship between the levels of CSF core biomarkers including Aβ-42, TAU, and P-TAU and plasma lipoproteins and metabolites of patients with AD from the baseline cohort of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Method. Using the ADNI database, fourteen subclasses of lipoproteins as well as a number of lipids and fatty acids and low-molecular metabolites including amino acids, ketone bodies, and glycolysis-related metabolites in blood samples were measured as potential noninvasive markers, and their association with the CSF core biomarkers was statistically investigated controlling for age and gender. Results. A total number of 251 AD subjects were included, among whom 71 subjects were negative for the Apo-E ε4 allele and 150 were positive. There was no significant difference between the two groups regarding cognitive assessments, CSF core biomarkers, and lipoproteins and metabolites except the level of Aβ-42 (p<0.001) and phenylalanine (p=0.049), which were higher in the negative group. CSF TAU and P-TAU were significantly correlated with medium and small HDL in the negative group, and with extremely large VLDL in the positive group. Our results also indicated significant correlations of metabolites including unsaturated fatty acids, glycerol, and leucine with CSF core biomarkers. Conclusion. Based on our findings, a number of lipoproteins and metabolites were associated with CSF core biomarkers of AD. These correlations showed some differences in Apo-E ε4 positive and negative groups, which reminds the role of Apo-E gene status in the pathophysiology of AD development. However, further research is warranted to explore the exact association of lipoproteins and other metabolites with AD core biomarkers and pathology.
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Academic Editor: Sean Keng Rui Chia
ISSN:2090-8024
2090-0252
2090-0252
DOI:10.1155/2023/3540020