Genotoxic analysis of nickel–iron oxide in Drosophila

Genotoxic analysis of nickel–iron oxide in Drosophila

It is known that nickel–iron oxide nanocomposite (NiFe2O4NP) is used in many important areas such as modern industry, biomedical applications, magnetic resonance imaging, construction of sensors, targeted drug treatment, and photoelectric devices in our life. In this study, we have carried out a gen...

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Bibliographic Details
Published in:Toxicology and industrial health Vol. 36; no. 11; pp. 835 - 843
Main Authors: Nas, Burhan, Çolak, Deniz Altun
Format: Journal Article
Language:English
Published: London, England SAGE Publications 01-11-2020
Sage Publications Ltd
Subjects:
Biomedical materials
Chromosomes
Evaluation
Fruit flies
Gene deletion
Genotoxicity
Imaginal discs
Insects
Iron oxides
Larvae
Magnetic resonance imaging
Mutants
Mutation
Nanocomposites
Nanoparticles
Nickel
Nondisjunction
Photoelectricity
Point mutation
Recombination
Spots
Trichomes
nickel–iron oxide nanocomposite
somatic mutation
Drosophila melanogaster
wing spot assay
Genotoxicity
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Summary:It is known that nickel–iron oxide nanocomposite (NiFe2O4NP) is used in many important areas such as modern industry, biomedical applications, magnetic resonance imaging, construction of sensors, targeted drug treatment, and photoelectric devices in our life. In this study, we have carried out a genotoxic evaluation of NiFe2O4NP (30 nm) in Drosophila melanogaster by using the wing somatic mutation and recombination assay. For this purpose, third instar larvae carrying the recessive genes (flr3 ) and multiple wing hairs (mwh) in their third chromosomes were used. The larvae were fed at concentrations ranging from 25 µg/mL to 200 µg/mL. The genotoxic effects of NiFe2O4NPs were evaluated according to mutant trichomes resulting from genetic changes (mitotic recombination, deletion, point mutation, nondisjunction) on development of the wing imaginal discs. Mutant clone evaluations were performed based on small single spots, large single spots, and twin spots classifications. The results showed that significant increases were observed in the frequency of all spots, indicating that the highest concentration of nanoparticles was able to induce genotoxic activity in the wing spot assay of D. melanogaster.
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ISSN:0748-2337
1477-0393
DOI:10.1177/0748233720947575