Follow-up Monoclonal Gammopathy of Undetermined Significance in Kidney Transplant

Abstract Objective The aim of this work was to review the incidence of monoclonal gammopathy of undetermined significance (MGUS) and complications in kidney transplant (KT) patients at the Puerta del Mar Hospital in Cádiz, Spain. This diagnosis was not considered to be a contraindication for transpl...

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Published in:	Transplantation proceedings Vol. 47; no. 1; pp. 78 - 80
Main Authors:	Cuéllar-García, C, Sevillano Ruiz-Mateos, C, Mazuecos Blanca, M.A, Narvaez Mejia, C, Fernandez Valle, M.C, Martin Reina, V, Gonzalez Bernal, M, Yera Cobo, M, Rodriguez Lopez, R, de Cos Hohr, C, Garrastazul, M.P, Marchante, I, Paz Coll, A, Capote Huelva, F.J
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 2015
Subjects:	Adult Aged Female Follow-Up Studies Humans Incidence Kidney Transplantation Male Middle Aged Monoclonal Gammopathy of Undetermined Significance - epidemiology Monoclonal Gammopathy of Undetermined Significance - etiology Outcome Assessment (Health Care) Postoperative Complications - epidemiology Retrospective Studies Spain Surgery Spain
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Summary:	Abstract Objective The aim of this work was to review the incidence of monoclonal gammopathy of undetermined significance (MGUS) and complications in kidney transplant (KT) patients at the Puerta del Mar Hospital in Cádiz, Spain. This diagnosis was not considered to be a contraindication for transplantation. Methods To estimate the incidence of MGUS in KT patients we used the database of our hospital, which included 1,016 patients who received a KT from 1992 to 2012 with a median follow-up of 30 months. The incidence of MGUS in non-transplant patients was estimated from the literature. Results Out of 1,016 KT patients, 16 developed MGUS; 10 (72.5%) were >50 years old. Two patients developed post-transplantation lymphoproliferative disorders. No cases of progression to multiple myeloma or amyloidosis were seen during immune suppression therapy or after. Conclusions MGUS was >100 times more frequent in KT recipients than in the general population ( P < .05). But in contrast to MGUS in general population, progression to plasma cell dyscrasia in these patients was absent and its incidence is unknown in KT patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0041-1345 1873-2623
DOI:	10.1016/j.transproceed.2014.11.021