Search Results - "Narumiya, Shuh"

Prostaglandin‐cytokine crosstalk in chronic inflammation by Yao, Chengcan, Narumiya, Shuh

“…Chronic inflammation underlies various debilitating disorders including autoimmune, neurodegenerative, vascular and metabolic diseases as well as cancer, where…”
Get full text

Rho signaling research: history, current status and future directions by Narumiya, Shuh, Thumkeo, Dean

“…One of the main research areas in biology from the mid‐1980s through the 1990s was the elucidation of signaling pathways governing cell responses. These…”
Get full text

Prostanoid Receptors by Hirata, Takako, Narumiya, Shuh

“…Hirata and Narumiya examine prostanoid receptors. They focus on, among other things, prostanoid receptor signal transduction…”
Get full text

Prostanoids and inflammation: a new concept arising from receptor knockout mice by Narumiya, Shuh

“…Prostanoids including various types of prostaglandins and thromboxanes are arachidonate metabolites produced and released in response to a variety of…”
Get full text

Prostaglandin E Receptors by Sugimoto, Yukihiko, Narumiya, Shuh

“…Prostaglandin (PG) E2 exerts its actions by acting on a group of G-protein-coupled receptors (GPCRs). There are four GPCRs responding to PGE2 designated…”
Get full text

Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion by Narumiya, Shuh, Tanji, Masahiro, Ishizaki, Toshimasa

“…The Rho subgroup of the Rho GTPases consisting of RhoA, RhoB and RhoC induces a specific type of actin cytoskeleton and carry out a variety of functions in the…”
Get full text

Physiological roles of Rho and Rho effectors in mammals by Thumkeo, Dean, Watanabe, Sadanori, Narumiya, Shuh

“…Rho GTPase is a master regulator controlling cytoskeleton in multiple contexts such as cell migration, adhesion and cytokinesis. Of several Rho GTPases in…”
Get full text

The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation by Nie, Xiang, Kitaoka, Shiho, Tanaka, Kohei, Segi-Nishida, Eri, Imoto, Yuki, Ogawa, Atsubumi, Nakano, Fumitake, Tomohiro, Ayaka, Nakayama, Kazuki, Taniguchi, Masayuki, Mimori-Kiyosue, Yuko, Kakizuka, Akira, Narumiya, Shuh, Furuyashiki, Tomoyuki

“…Repeated environmental stress has been proposed to induce neural inflammation together with depression and anxiety. Innate immune receptors, such as Toll-like…”
Get full text

Roles of hepatic stellate cells in liver inflammation: a new perspective by Fujita, Tomoko, Narumiya, Shuh

“…Connected with the intestinal tract through the portal circulation, liver sinusoids function as the first line of defense against extrahepatic stimuli such as…”
Get full text

Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion by Yao, Chengcan, Sakata, Daiji, Esaki, Yoshiyasu, Li, Youxian, Matsuoka, Toshiyuki, Kuroiwa, Kenji, Sugimoto, Yukihiko, Narumiya, Shuh

“…Prostaglandins play a key role in inflammation in a variety of settings. Now, Shuh Narumiya and colleagues show that prostaglandin E2 drives the production of…”
Get full text

Prostaglandin E 2 (PGE 2 )-EP2 signaling negatively regulates murine atopic dermatitis-like skin inflammation by suppressing thymic stromal lymphopoietin expression by Sawada, Yu, Honda, Tetsuya, Nakamizo, Satoshi, Nakajima, Saeko, Nonomura, Yumi, Otsuka, Atsushi, Egawa, Gyohei, Yoshimoto, Tomohiro, Nakamura, Motonobu, Narumiya, Shuh, Kabashima, Kenji

“…Atopic dermatitis (AD) is a common and chronic inflammatory skin disease of type 2 immunity. Keratinocyte-derived cytokines, including thymic stromal…”
Get full text

Role of JAK-STAT signaling in the pathogenic behavior of fibroblast-like synoviocytes in rheumatoid arthritis: Effect of the novel JAK inhibitor peficitinib by Emori, Takashi, Kasahara, Michiko, Sugahara, Shingo, Hashimoto, Motomu, Ito, Hiromu, Narumiya, Shuh, Higashi, Yasuyuki, Fujii, Yasutomo

“…Rheumatoid arthritis (RA) fibroblast-like synoviocytes (RA-FLS) play a crucial role in the pathogenesis of RA. RA-FLS display passive pro-inflammatory…”
Get full text

Prostaglandin E2 directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF‐β signalling by Goepp, Marie, Crittenden, Siobhan, Zhou, You, Rossi, Adriano G, Narumiya, Shuh, Yao, Chengcan

“…Regulatory T (Treg) cells are essential for control of inflammatory processes by suppressing effector T‐cell functions. The actions of PGE2 on the development…”
Get full text

Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface by Toyoda, Yosuke, Morimoto, Kazushi, Suno, Ryoji, Horita, Shoichiro, Yamashita, Keitaro, Hirata, Kunio, Sekiguchi, Yusuke, Yasuda, Satoshi, Shiroishi, Mitsunori, Shimizu, Tomoko, Urushibata, Yuji, Kajiwara, Yuta, Inazumi, Tomoaki, Hotta, Yunhon, Asada, Hidetsugu, Nakane, Takanori, Shiimura, Yuki, Nakagita, Tomoya, Tsuge, Kyoshiro, Yoshida, Suguru, Kuribara, Tomoko, Hosoya, Takamitsu, Sugimoto, Yukihiko, Nomura, Norimichi, Sato, Miwa, Hirokawa, Takatsugu, Kinoshita, Masahiro, Murata, Takeshi, Takayama, Kiyoshi, Yamamoto, Masaki, Narumiya, Shuh, Iwata, So, Kobayashi, Takuya

“…Prostaglandin E receptor EP4, a G-protein-coupled receptor, is involved in disorders such as cancer and autoimmune disease. Here, we report the crystal…”
Get full text

Prostaglandin E2, an Immunoactivator by Sakata, Daiji, Yao, Chengcan, Narumiya, Shuh

“…Diseases caused by immune inflammation, such as rheumatoid arthritis, multiple sclerosis, and Crohn’s disease, are intractable diseases to which novel…”
Get full text

Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells by Ohgushi, Masatoshi, Matsumura, Michiru, Eiraku, Mototsugu, Murakami, Kazuhiro, Aramaki, Toshihiro, Nishiyama, Ayaka, Muguruma, Keiko, Nakano, Tokushige, Suga, Hidetaka, Ueno, Morio, Ishizaki, Toshimasa, Suemori, Hirofumi, Narumiya, Shuh, Niwa, Hitoshi, Sasai, Yoshiki

“…Human embryonic stem cells (hESCs), unlike mouse ones (mESCs), are vulnerable to apoptosis upon dissociation. Here, we show that the apoptosis, which is of a…”
Get full text

Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis by Duffin, Rodger, O'Connor, Richard A., Crittenden, Siobhan, Forster, Thorsten, Yu, Cunjing, Zheng, Xiaozhong, Smyth, Danielle, Robb, Calum T., Rossi, Fiona, Skouras, Christos, Tang, Shaohui, Richards, James, Pellicoro, Antonella, Weller, Richard B., Breyer, Richard M., Mole, Damian J., Iredale, John P., Anderton, Stephen M., Narumiya, Shuh, Maizels, Rick M., Ghazal, Peter, Howie, Sarah E., Rossi, Adriano G., Yao, Chengcan

“…Systemic inflammation, which results from the massive release of proinflammatory molecules into the circulatory system, is a major risk factor for severe…”
Get full text

High salt induces cognitive impairment via the interaction of the angiotensin II‐AT1 and prostaglandin E2‐EP1 systems by Kubota, Hisayoshi, Kunisawa, Kazuo, Wulaer, Bolati, Hasegawa, Masaya, Kurahashi, Hitomi, Sakata, Takatoshi, Tezuka, Hiroyuki, Kugita, Masanori, Nagao, Shizuko, Nagai, Taku, Furuyashiki, Tomoyuki, Narumiya, Shuh, Saito, Kuniaki, Nabeshima, Toshitaka, Mouri, Akihiro

“…Background and Purpose High salt (HS) intake has been associated with hypertension and cognitive impairment. It is well known that the angiotensin II (Ang…”
Get full text

Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice by Hosono, Kanako, Isonaka, Risa, Kawakami, Tadashi, Narumiya, Shuh, Majima, Masataka

“…Lymphangiogenesis plays an important role in homeostasis, metabolism, and immunity, and also occurs during wound-healing. Here, we examined the roles of…”
Get full text

Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation by Morimoto, Kazushi, Shirata, Naritoshi, Taketomi, Yoshitaka, Tsuchiya, Soken, Segi-Nishida, Eri, Inazumi, Tomoaki, Kabashima, Kenji, Tanaka, Satoshi, Murakami, Makoto, Narumiya, Shuh, Sugimoto, Yukihiko

“…PGE2 has long been known as a potentiator of acute inflammation, but its mechanisms of action still remain to be defined. In this study, we employed…”
Get full text