Search Results - "Narumiya, S"

International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress by Woodward, D F, Jones, R L, Narumiya, S

“…It is now more than 15 years since the molecular structures of the major prostanoid receptors were elucidated. Since then, substantial progress has been…”
Get full text

Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice by Shinohara, R, Taniguchi, M, Ehrlich, A T, Yokogawa, K, Deguchi, Y, Cherasse, Y, Lazarus, M, Urade, Y, Ogawa, A, Kitaoka, S, Sawa, A, Narumiya, S, Furuyashiki, T

“…Dopamine in prefrontal cortices is implicated in cognitive and emotional functions, and the dysfunction of prefrontal dopamine has been associated with…”
Get full text

EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contractions by Ota, H., Katanosaka, K., Murase, S., Furuyashiki, T., Narumiya, S., Mizumura, K.

“…We previously demonstrated that nerve growth factor (NGF) and glial cell line‐derived neurotrophic factor (GDNF) were upregulated after lengthening…”
Get full text

Genetic and pharmacological analysis of prostanoid receptor function by Narumiya, S, FitzGerald, G A

Get full text

Prostaglandin receptor signaling in disease by Matsuoka, Toshiyuki, Narumiya, Shuh

“…Prostanoids, consisting of the prostaglandins (PGs) and the thromboxanes (TXs), are a group of lipid mediators formed in response to various stimuli. They…”
Get full text

The Small GTPase Rho: Cellular Functions and Signal Transduction by Narumiya, S

“…Rho, a Ras homologue of small GTPase, is present from yeast to mammals. It shuttles between the active GTP-bound form and the inactive GDP-bound form and works…”
Get full text

Neuroprotective properties of prostaglandin I2 IP receptor in focal cerebral ischemia by Saleem, S, Shah, Z.A, Maruyama, T, Narumiya, S, Doré, S

“…Abstract We and others have identified that inhibition of cyclooxygenase might not be the optimal approach to limiting brain damage after stroke. Now we are…”
Get full text

Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors by Oka, Takakazu, Oka, Kae, Kobayashi, Takuya, Sugimoto, Yukihiko, Ichikawa, Atsushi, Ushikubi, Fumitaka, Narumiya, Shuh, Saper, Clifford B

“…Previous studies have disagreed about whether prostaglandin EP 1 or EP 3 receptors are critical for producing febrile responses. We therefore injected…”
Get full text

Effects of Rho-Associated Protein Kinase Inhibitor Y-27632 on Intraocular Pressure and Outflow Facility by Honjo, Megumi, Tanihara, Hidenobu, Inatani, Masaru, Kido, Noriaki, Sawamura, Tatsuya, Yue, Beatrice Y. J. T, Narumiya, Shuh, Honda, Yoshihito

“…To elucidate the roles of Rho-associated protein kinase (ROCK) in regulating intraocular pressure (IOP) and outflow facility in the rabbit eye. A specific ROCK…”
Get full text

The small GTP‐binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase by Ishizaki, T., Maekawa, M., Fujisawa, K., Okawa, K., Iwamatsu, A., Fujita, A., Watanabe, N., Saito, Y., Kakizuka, A., Morii, N., Narumiya, S.

“…The small GTP‐binding protein Rho functions as a molecular switch in the formation of focal adhesions and stress fibers, cytokinesis and transcriptional…”
Get full text

Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development by Shoji, Y, Takahashi, M, Kitamura, T, Watanabe, K, Kawamori, T, Maruyama, T, Sugimoto, Y, Negishi, M, Narumiya, S, Sugimura, T, Wakabayashi, K

“…Background and aims: Involvement of prostaglandin E2 (PGE2) receptors EP1, EP2, and EP4 in the formation of aberrant crypt foci (ACF) and/or intestinal polyps…”
Get full text

Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D2 receptor (DP)‐dependent pathway by Eguchi, M., Kariya, S., Okano, M., Higaki, T., Makihara, S., Fujiwara, T., Nagata, K., Hirai, H., Narumiya, S., Nakamura, M., Nishizaki, K.

“…Summary Otitis media is one of the most common and intractable ear diseases, and is the major cause of hearing loss, especially in children. Multiple factors…”
Get full text

The Role of Prostaglandin E Receptor Subtypes (EP1, EP2, EP3, and EP4) in Bone Resorption: An Analysis Using Specific Agonists for the Respective EPs by Suzawa, Tetsuo, Miyaura, Chisato, Inada, Masaki, Maruyama, Takayuki, Sugimoto, Yukihiko, Ushikubi, Fumitaka, Ichikawa, Atsushi, Narumiya, Shuh, Suda, Tatsuo

“…PGE2 functions as a potent stimulator of bone resorption. The action of PGE2 is thought to be mediated by some PGE receptor subtypes present in osteoblastic…”
Get full text

Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation by Toshima, J, Toshima, J Y, Amano, T, Yang, N, Narumiya, S, Mizuno, K

“…Testicular protein kinase 1 (TESK1) is a serine/threonine kinase with a structure composed of a kinase domain related to those of LIM-kinases and a unique…”
Get full text

mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse by Thumkeo, D, Katsura, Y, Nishimura, Y, Kanchanawong, P, Tohyama, K, Ishizaki, T, Kitajima, S, Takahashi, C, Hirata, T, Watanabe, N, Krummel, M F, Narumiya, S

“…The mechanism by which the cytosolic protein Zap70 physically interacts with and phosphorylates its substrate, the transmembrane protein LAT, upon T cell…”
Get full text

LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505 by Amano, T, Tanabe, K, Eto, T, Narumiya, S, Mizuno, K

“…LIM-kinase 1 and 2 (LIMK1 and LIMK2) phosphorylate cofilin and induce actin cytoskeletal reorganization. LIMK1 is activated by Rho-associated,…”
Get full text

Stimulation of prostaglandin E2 -EP3 receptors exacerbates stroke and excitotoxic injury by Ahmad, Muzamil, Ahmad, Abdullah Shafique, Zhuang, Hean, Maruyama, Takayuki, Narumiya, Shuh, Doré, Sylvain

“…Abstract The effect of PGE2 EP3 receptors on injury size was investigated following cerebral ischemia and induced excitotoxicity in mice. Treatment with the…”
Get full text

Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas by SUWA, H, OHSHIO, G, IMAMURA, T, WATANABE, G, ARLI, S, IMAMURA, M, NARUMIYA, S, HIAL, H, FUKUMOTO, M

“…It has been reported that the rho genes, which consist of a ras-related small GTPase protein family, regulate cytoskeletal structures and have the potential to…”
Get full text

Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype by HONDA, A, SUGIMOTO, Y, NAMBA, T, WATABE, A, IRIE, A, NEGISHI, M, NARUMIYA, S, ICHIKAWA, A

“…A functional cDNA clone encoding mouse EP2 subtype of prostaglandin (PG) E receptor was isolated from a mouse cDNA library by cross-hybridization with the…”
Get full text

The IOP-lowering effects and mechanism of action of tafluprost in prostanoid receptor-deficient mice by Ota, Takashi, Aihara, Makoto, Saeki, Tadashiro, Narumiya, Shuh, Araie, Makoto

“…Aim: To clarify the intraocular pressure (IOP)-lowering profile of tafluprost, a newly synthesised prostaglandin F2α analogue, in mice. Methods: C57BL/6J, and…”
Get full text