Search Results - "Narumi, Hiroaki"

Synthesis and Antitumor Activity of Novel O-Carbamoylmethyloxime Derivatives of Radicicol by Ikuina, Yoji, Amishiro, Nobuyoshi, Miyata, Mayumi, Narumi, Hiroaki, Ogawa, Harumi, Akiyama, Tadakazu, Shiotsu, Yukimasa, Akinaga, Shiro, Murakata, Chikara

“…Radicicol (1), a macrocyclic antifungal antibiotic, is the lead compound of a novel class of heat shock protein 90 (Hsp90) inhibitors that result in the…”
Get full text

Radicicol Leads to Selective Depletion of Raf Kinase and Disrupts K-Ras-activated Aberrant Signaling Pathway by Soga, Shiro, Kozawa, Takako, Narumi, Hiroaki, Akinaga, Shiro, Irie, Kenji, Matsumoto, Kunihiro, Sharma, Sreenath V., Nakano, Hirofumi, Mizukami, Tamio, Hara, Mitsunobu

“…Activation of Ras leads to the constitutive activation of a downstream phosphorylation cascade comprised of Raf-1, mitogen-activated protein kinase (MAPK)…”
Get full text

Purification, some properties, and primary structure of a base non-specific ribonuclease from oyster (Crussdstrea grigus) by Watanabe, H, Narumi, H, Inaba, T, Ohgi, K, Irie, M

“…A ribonuclease (RNase Oy) was purified to homogeneity on SDS-PAGE from the homogenate of oyster (Crussdstrea grigus). The apparent molecular weight estimated…”
Get more information

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules by SOGA, S, NECKERS, L. M, AKINAGA, S, SCHULTE, T. W, SHIOTSU, Y, AKASAKA, K, NARUMI, H, AGATSUMA, T, IKUINA, Y, MURAKATA, C, TAMAOKI, T

“…Radicicol, a macrocyclic antifungal antibiotic, has been shown to bind to the heat shock protein 90 (Hsp90) chaperone, interfering with its function. Hsp90…”
Get full text