Search Results - "Narukulla, Raman"

Post-synthetic and site-specific modification of endocyclic nitrogen atoms of purines in DNA and its potential for biological and structural studies by Narukulla, Raman, Shuker, David E. G., Xu, Yao-Zhong

“…Site-specific modification of the N1-position of purine was explored at the nucleoside and oligomer levels. 2′-Deoxyinosine was converted into an…”
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Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα by Hanan, Emily J., Braun, Marie-Gabrielle, Heald, Robert A., MacLeod, Calum, Chan, Connie, Clausen, Saundra, Edgar, Kyle A., Eigenbrot, Charles, Elliott, Richard, Endres, Nicholas, Friedman, Lori S., Gogol, Emily, Gu, Xiao-Hui, Thibodeau, Rebecca Hong, Jackson, Philip S., Kiefer, James R., Knight, Jamie D., Nannini, Michelle, Narukulla, Raman, Pace, Amanda, Pang, Jodie, Purkey, Hans E., Salphati, Laurent, Sampath, Deepak, Schmidt, Stephen, Sideris, Steve, Song, Kyung, Sujatha-Bhaskar, Swathi, Ultsch, Mark, Wallweber, Heidi, Xin, Jianfeng, Yeap, SiewKuen, Young, Amy, Zhong, Yu, Staben, Steven T.

“…Small molecule inhibitors that target the phosphatidylinositol 3-kinase (PI3K) signaling pathway have received significant interest for the treatment of…”
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Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors by Kulagowski, Janusz J, Blair, Wade, Bull, Richard J, Chang, Christine, Deshmukh, Gauri, Dyke, Hazel J, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Harrison, Trevor K, Hewitt, Peter R, Liimatta, Marya, Hurley, Christopher A, Johnson, Adam, Johnson, Tony, Kenny, Jane R, Bir Kohli, Pawan, Maxey, Robert J, Mendonca, Rohan, Mortara, Kyle, Murray, Jeremy, Narukulla, Raman, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, Ultsch, Mark, van Abbema, Anne, Ward, Stuart I, Waszkowycz, Bohdan, Zak, Mark

“…A therapeutic rationale is proposed for the treatment of inflammatory diseases, such as rheumatoid arthritis (RA), by specific targeting of the JAK1 pathway…”
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Identification of C‑2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2 by Zak, Mark, Hurley, Christopher A, Ward, Stuart I, Bergeron, Philippe, Barrett, Kathy, Balazs, Mercedesz, Blair, Wade S, Bull, Richard, Chakravarty, Paroma, Chang, Christine, Crackett, Peter, Deshmukh, Gauri, DeVoss, Jason, Dragovich, Peter S, Eigenbrot, Charles, Ellwood, Charles, Gaines, Simon, Ghilardi, Nico, Gibbons, Paul, Gradl, Stefan, Gribling, Peter, Hamman, Chris, Harstad, Eric, Hewitt, Peter, Johnson, Adam, Johnson, Tony, Kenny, Jane R, Koehler, Michael F. T, Bir Kohli, Pawan, Labadie, Sharada, Lee, Wyne P, Liao, Jiangpeng, Liimatta, Marya, Mendonca, Rohan, Narukulla, Raman, Pulk, Rebecca, Reeve, Austin, Savage, Scott, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, van Abbema, Anne, Aliagas, Ignacio, Avitabile-Woo, Barbara, Xiao, Yisong, Yang, Jing, Kulagowski, Janusz J

“…Herein we report on the structure-based discovery of a C-2 hydroxyethyl moiety which provided consistently high levels of selectivity for JAK1 over JAK2 to the…”
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Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1 by Gazzard, Lewis, Williams, Karen, Chen, Huifen, Axford, Lorraine, Blackwood, Elizabeth, Burton, Brenda, Chapman, Kerry, Crackett, Peter, Drobnick, Joy, Ellwood, Charles, Epler, Jennifer, Flagella, Michael, Gancia, Emanuela, Gill, Matthew, Goodacre, Simon, Halladay, Jason, Hewitt, Joanne, Hunt, Hazel, Kintz, Samuel, Lyssikatos, Joseph, Macleod, Calum, Major, Sarah, Médard, Guillaume, Narukulla, Raman, Ramiscal, Judi, Schmidt, Stephen, Seward, Eileen, Wiesmann, Christian, Wu, Ping, Yee, Sharon, Yen, Ivana, Malek, Shiva

“…Checkpoint kinase 1 (ChK1) plays a key role in the DNA damage response, facilitating cell-cycle arrest to provide sufficient time for lesion repair. This leads…”
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Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1 by Hurley, Christopher A., Blair, Wade S., Bull, Richard J., Chang, Christine, Crackett, Peter H., Deshmukh, Gauri, Dyke, Hazel J., Fong, Rina, Ghilardi, Nico, Gibbons, Paul, Hewitt, Peter R., Johnson, Adam, Johnson, Tony, Kenny, Jane R., Kohli, Pawan Bir, Kulagowski, Janusz J., Liimatta, Marya, Lupardus, Patrick J., Maxey, Robert J., Mendonca, Rohan, Narukulla, Raman, Pulk, Rebecca, Ubhayakar, Savita, van Abbema, Anne, Ward, Stuart I., Waszkowycz, Bohdan, Zak, Mark

“…The identification of a novel fused triazolo-pyrrolopyridine scaffold, optimized derivatives of which display nanomolar inhibition of Janus kinase 1, is…”
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Unambiguous structural elucidation of base-modified purine nucleosides using NMR by Narukulla, Raman, Shuker, David E. G., Ramesh, Vasudevan, Xu, Yao-Zhong

“…A general and unambiguous approach has been developed for structural elucidation of modified purine nucleosides using NMR spectroscopy. Systematic assignment…”
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A new trimethoxychalcone from C rotalaria ramosissima by Rao, Meneni Srinivasa, Narukulla, Raman

“…A new trimethoxychalcone ( 1) was isolated from the aerial parts of Crotalaria ramosissima. The structure was elucidated on the basis of 1H NMR, 13C NMR and MS…”
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A new trimethoxychalcone from Crotalaria ramosissima by SRINIVASA RAO, Meneni, NARUKULLA, Raman

“…A new trimethoxychalcone (1) was isolated from the aerial parts of Crotalaria ramosissima. The structure was elucidated on the basis of (1)H NMR, (13)C NMR and…”
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