Search Results - "Narsa Reddy, M"

PI3K-AKT Signaling via Nrf2 Protects against Hyperoxia-Induced Acute Lung Injury, but Promotes Inflammation Post-Injury Independent of Nrf2 in Mice by Reddy, Narsa M, Potteti, Haranatha R, Vegiraju, Suryanarayana, Chen, Hsin-Jou, Tamatam, Chandra Mohan, Reddy, Sekhar P

“…Lung epithelial and endothelial cell death accompanied by inflammation contributes to hyperoxia-induced acute lung injury (ALI). Impaired resolution of ALI can…”
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The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia-reperfusion injury in mice by Liu, Manchang, Reddy, Narsa M, Higbee, Elizabeth M, Potteti, Haranatha R, Noel, Sanjeev, Racusen, Lorraine, Kensler, Thomas W, Sporn, Michael B, Reddy, Sekhar P, Rabb, Hamid

“…Acute kidney injury (AKI) caused by ischemia-reperfusion is a major clinical problem in both native and transplanted kidneys. We had previously shown that…”
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Metformin alleviates lung-endothelial hyperpermeability by regulating cofilin-1/PP2AC pathway by Siddiqui, M Rizwan, Reddy, Narsa M, Faridi, Hafeez M, Shahid, Mohd, Shanley, Thomas P

“…Microvascular endothelial hyperpermeability is an earliest pathological hallmark in Acute Lung Injury (ALI), which progressively leads to Acute Respiratory…”
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Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammation by Reddy, Narsa M, Potteti, Haranatha R, Mariani, Thomas J, Biswal, Shyam, Reddy, Sekhar P

“…Oxidant stress, resulting from an excess of reactive electrophiles produced in the lung by both resident (epithelial and endothelial) and infiltrated…”
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Disruption of Nrf2 Impairs the Resolution of Hyperoxia-Induced Acute Lung Injury and Inflammation in Mice by Reddy, Narsa M, Kleeberger, Steven R, Kensler, Thomas W, Yamamoto, Masayuki, Hassoun, Paul M, Reddy, Sekhar P

“…Aberrant tissue repair and persistent inflammation following oxidant-mediated acute lung injury (ALI) can lead to the development and progression of various…”
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Nrf2 Is Required for Optimal Alveolar-Macrophage-Mediated Apoptotic Neutrophil Clearance after Oxidant Injury by Reddy, Narsa M, Tamatam, Chandra Mohan, Aparna, Ankireddy, Reddy, Sekhar P

“…Recognition and clearance of apoptotic cells by phagocytes (also known as efferocytosis), primarily mediated by macrophages, are essential to terminate lung…”
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Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia by Natarajan, Viswanathan, Ha, Alison W, Dong, Yangbasai, Reddy, Narsa M, Ebenezer, David L, Kanteti, Prasad, Reddy, Sekhar P, Usha Raj, J, Lei, Zhengdeng, Maienschein-Cline, Mark, Arbieva, Zarema, Harijith, Anantha

“…Sphingosine- 1-Phosphate (S1P) is a bioactive lipid and an intracellular as well as an extracellular signaling molecule. S1P ligand specifically binds to five…”
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Innate Immunity against Bacterial Infection following Hyperoxia Exposure Is Impaired in NRF2-Deficient Mice by Reddy, Narsa M, Suryanarayana, Vegiraju, Kalvakolanu, Dhananjaya V, Yamamoto, Masayuki, Kensler, Thomas W, Hassoun, Paul M, Kleeberger, Steven R, Reddy, Sekhar P

“…Oxygen supplementation is used as therapy to support critically ill patients with severe respiratory impairment. Although hyperoxia has been shown to enhance…”
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The Triterpenoid CDDO-Imidazolide Confers Potent Protection against Hyperoxic Acute Lung Injury in Mice by Reddy, Narsa M, Suryanaraya, Vegiraju, Yates, Melinda S, Kleeberger, Steven R, Hassoun, Paul M, Yamamoto, Masayuki, Liby, Karen T, Sporn, Michael B, Kensler, Thomas W, Reddy, Sekhar P

“…Oxygen supplementation (e.g., hyperoxia) is used to support critically ill patients with noninfectious and infectious acute lung injury (ALI); however,…”
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Genetic and Pharmacologic Evidence Links Oxidative Stress to Ventilator-induced Lung Injury in Mice by Papaiahgari, Srinivas, Yerrapureddy, Adi, Reddy, Swetha R, Reddy, Narsa M, Dodd-O, Jeffery M, Crow, Michael T, Grigoryev, Dimitry N, Barnes, Kathleen, Tuder, Rubin M, Yamamoto, Masayuki, Kensler, Thomas W, Biswal, Shyam, Mitzner, Wayne, Hassoun, Paul M, Reddy, Sekhar P

“…Mechanical ventilation (MV) is an indispensable therapy for critically ill patients with acute lung injury and the adult respiratory distress syndrome…”
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Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection by Reddy, Narsa M, Kleeberger, Steven R, Yamamoto, Masayuki, Kensler, Thomas W, Scollick, Catherine, Biswal, Shyam, Reddy, Sekhar P

“…1 Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 2 National Institute of Environmental…”
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Deficiency in Nrf2-GSH Signaling Impairs Type II Cell Growth and Enhances Sensitivity to Oxidants by Reddy, Narsa M, Kleeberger, Steven R, Cho, Hye-Youn, Yamamoto, Masayuki, Kensler, Thomas W, Biswal, Shyam, Reddy, Sekhar P

“…Redox imbalance has been implicated in the pathogenesis of many acute and chronic lung diseases. The b-Zip transcription factor Nrf2 acts via an…”
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Targeted Deletion of Jun/AP-1 in Alveolar Epithelial Cells Causes Progressive Emphysema and Worsens Cigarette Smoke–Induced Lung Inflammation by Reddy, Narsa M, Vegiraju, Suryanaraya, Irving, Ashley, Paun, Bogdan C, Luzina, Irina G, Atamas, Sergei P, Biswal, Shyam, Ana, Navas-Acien, Mitzner, Wayne, Reddy, Sekhar P

“…Chronic obstructive pulmonary disease appears to occur slowly and progressively over many years, with both genetic factors and environmental modifiers…”
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Higher Order Arrangement of the Eukaryotic Nuclear Bodies by I-Fan Wang, Reddy, Narsa M., C.-K. James Shen

“…The nuclei of eukaryotic cells consist of discrete substructures. These substructures include the nuclear bodies, which have been implicated in a number of…”
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Epidermal Growth Factor receptor (EGFR) regulates mechanical ventilation–induced lung injury in mice by Bierman, Alexis, Yerrapureddy, Adi, Reddy, Narsa M, Hassoun, Paul M, Reddy, Sekhar P

“…Mechanical ventilation (MV) is used as therapy to support critically ill patients; however, the mechanisms by which MV induces lung injury and inflammation…”
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FOSL1 Promotes Kras-induced Lung Cancer through Amphiregulin and Cell Survival Gene Regulation by Elangovan, Indira M, Vaz, Michelle, Tamatam, Chandramohan R, Potteti, Haranatha R, Reddy, Narsa M, Reddy, Sekhar P

“…The FOSL1/AP-1 transcription factor regulates gene expression, thereby controlling various pathophysiological processes. It is a major effector of RAS-ERK1/2…”
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The Eukaryotic DNMT2 Genes Encode a New Class of Cytosine-5 DNA Methyltransferases by Tang, Lin-Ya, Reddy, M.Narsa, Rasheva, Vanya, Lee, Tai-Lin, Lin, Meng-Jau, Hung, Ming-Shiu, Shen, C.-K.James

“…DNMT2 is a subgroup of the eukaryotic cytosine-5 DNA methyltransferase gene family. Unlike the other family members, proteins encoded by DNMT2 genes were not…”
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DNA Methyltransferase Gene dDnmt2 and Longevity of Drosophila by Lin, Meng-Jau, Tang, Lin-Ya, Reddy, M. Narsa, Shen, C.-K. James

“…The DNA methylation program of the fruit fly Drosophila melanogaster is carried out by the single DNA methyltransferase gene dDnmt2, the function of which is…”
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Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice by Tamatam, Chandra M., Reddy, Narsa M., Potteti, Haranatha R., Ankireddy, Aparna, Noone, Patrick M., Yamamoto, Masayuki, Kensler, Thomas W., Reddy, Sekhar P.

“…Bronchopulmonary dysplasia (BPD) is a chronic disease of preterm babies with poor clinical outcomes. Nrf2 transcription factor is crucial for cytoprotective…”
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Nrf2-AKT interactions regulate heme oxygenase 1 expression in kidney epithelia during hypoxia and hypoxia-reoxygenation by Potteti, Haranatha R, Tamatam, Chandramohan R, Marreddy, Rakesh, Reddy, Narsa M, Noel, Sanjeev, Rabb, Hamid, Reddy, Sekhar P

“…Ischemia-reperfusion (IR)-induced kidney injury is a major clinical problem, but its underlying mechanisms remain unclear. The transcription factor known as…”
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