Search Results - "Narla, G."

Sin3a acts through a multi-gene module to regulate invasion in Drosophila and human tumors by Das, T K, Sangodkar, J, Negre, N, Narla, G, Cagan, R L

“…Chromatin remodeling proteins regulate multiple aspects of cell homeostasis, making them ideal candidates for misregulation in transformed cells. Here, we…”
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In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma by NARLA, G, KREMER-TALL, S, MATSUMOTO, N, ZHAO, X, YAO, S, KELLEY, K, TAROCCHIL, M, FRIEDMAN, S. L

“…Kruppel-like factor (KLF) 6 is a tumor-suppressor gene functionally inactivated by loss of heterozygosity, somatic mutation and/or alternative splicing that…”
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The use of novel PP2A activators in combination with PARP inhibitor for the treatment of high-grade serous ovarian cancer by Armstrong, A.J, Joseph, P, Nagaraj, A.B, Nagel, C.I, Nakayama, J, Waggoner, S.E, Zanotti, K.M, DiFeo, A, Narla, G

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486 Development of small molecule activators of protein phosphatase 2A for the treatment of lung cancer by Sangodkar, J, Mazhar, S, Kastrinsky, D, Ohlmeyer, M, Narla, G

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KLF6, a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer by Narla, Goutham, Heath, Karen E., Reeves, Helen L., Li, Dan, Giono, Luciana E., Kimmelman, Alec C., Glucksman, Marc J., Narla, Jyothsna, Eng, Francis J., Chan, Andrew M., Ferrari, Anna C., Martignetti, John A., Friedman, Scott L.

“…Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor of unknown function. Here, we show that the KLF6 gene is mutated in a subset of human…”
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Small molecule activators of protein phosphatase 2A for the treatment of endometrial cancer by Joseph, P, Nagaraj, A.B, Armstrong, A, Resnick, K.E, Zanotti, K.M, Waggoner, S.E, Narla, G, DiFeo, A

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548 Development of a small molecule activator of protein phosphatase 2A for the treatment of prostate cancer by McClinch, K, Callejas, D, Cooper, M, Stachnik, A, Kastrinsky, D, Ohlmeyer, M, Galsky, M, Narla, G

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E-cadherin is a novel transcriptional target of the KLF6 tumor suppressor by DiFeo, A, Narla, G, Camacho-Vanegas, O, Nishio, H, Rose, S L, Buller, R E, Friedman, S L, Walsh, M J, Martignetti, J A

“…The tumor suppressor KLF6 is a member of the Krüppel-like family of transcription factors, which has been implicated in the pathogenesis of several human…”
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Quantitative PCR array identification of microRNA clusters associated with epithelial ovarian cancer chemoresistance by Fishman, D, Wang, F, DiFeo, A, Narla, G

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Green synthesis of 1,2,3‐triazoles via Cu2O NPs on hydrogen trititanate nanotubes promoted 1,3‐dipolar cycloadditions by Bhoomireddy, Rajendra Prasad Reddy, Narla, L.G. Bhavani, Peddiahgari, Vasu Govardhana Reddy

“…Cu2O nanoparticles supported on hydrogen trititanate nanotubes (Cu2O/HTNT) catalysts have been efficiently catalyzed the multicomponent synthesis of…”
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DYSREGULATION OF TUMOR SUPPRESSOR KLF6 INCREASES HCC RELATED MORTALITY IN HCV INFECTED PATIENTS AND INCIDENCE OF TUMOR IN MOUSE MODEL OF HEPATIC CARCINOGENESIS by Tarocchi, M, Narla, G, Villanueva, A, Galli, A, Mazzaferro, V, Llovet, J, Friedman, S

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The use of novel PP2A activators in combination withPARP inhibitor for the treatment of high-grade serous ovarian cancer by Armstrong, A.J., Joseph, P., Nagaraj, A.B., Nagel, C.I., Nakayama, J., Waggoner, S.E., Zanotti, K.M., DiFeo, A., Narla, G.

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Bisphosphonates inactivate human EGFRs to exert antitumor actions by Yuen, Tony, Stachnik, Agnes, Iqbal, Jameel, Sgobba, Miriam, Gupta, Yogesh, Lu, Ping, Colaianni, Graziana, Ji, Yaoting, Zhu, Ling-Ling, Kim, Se-Min, Li, Jianhua, Liu, Peng, Izadmehr, Sudeh, Sangodkar, Jaya, Bailey, Jack, Latif, Yathin, Mujtaba, Shiraz, Epstein, Solomon, Davies, Terry F., Bian, Zhuan, Zallone, Alberta, Aggarwal, Aneel K., Haider, Shozeb, New, Maria I., Sun, Li, Narla, Goutham, Zaidi, Mone

“…Significance For over three decades, bisphosphonates have been used for the therapy of osteoporosis and skeletal metastasis. Here we show that this class of…”
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Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer by Stachnik, Agnes, Yuen, Tony, Iqbal, Jameel, Sgobba, Miriam, Gupta, Yogesh, Lu, Ping, Colaianni, Graziana, Ji, Yaoting, Zhu, Ling-Ling, Kim, Se-Min, Li, Jianhua, Liu, Peng, Izadmehr, Sudeh, Sangodkar, Jaya, Scherer, Thomas, Mujtaba, Shiraz, Galsky, Matthew, Gomez, Jorge, Epstein, Solomon, Buettner, Christoph, Bian, Zhuan, Zallone, Alberta, Aggarwal, Aneel K., Haider, Shozeb, New, Maria I., Sun, Li, Narla, Goutham, Zaidi, Mone

“…Significance Small molecules to target oncogenic signaling cascades in cancer have achieved success in molecularly defined patient subsets. The path to…”
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Krüppel-like Factor-6 Promotes Preadipocyte Differentiation through Histone Deacetylase 3-dependent Repression of DLK1 by Li, Dan, Yea, Steven, Li, Side, Chen, Zhu, Narla, Goutham, Banck, Michaela, Laborda, Jorge, Tan, Song, Friedman, Jeffrey M., Friedman, Scott L., Walsh, Martin J.

“…Preadipocyte differentiation occurs during distinct periods of human development and is a key determinant of body mass. Transcriptional events underlying…”
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Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread by NARLA, Goutham, DIFEO, Analisa, CHAN, Andrew M, FRIEDMAN, Scott L, MARTIGNETTI, John A, SHEN YAO, BANNO, Asoka, HOD, Eldad, REEVES, Helen L, QIAO, Rui F, CAMACHO-VANEGAS, Olga, LEVINE, Alice, KIRSCHENBAUM, Alexander

“…Prostate cancer is a leading cause of cancer death in men. Risk prognostication, treatment stratification, and the development of rational therapeutic…”
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A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk by NARLA, Goutham, DIFEO, Analisa, MCDONNELL, Shannon K, WILEY, Kathleen E, JACOBSEN, Steven J, ISAACS, Sarah D, WALSH, Patrick C, ZHENG, S. Lilly, CHANG, Bao-Li, FRIEDRICHSEN, Danielle M, STANFORD, Janet L, OSTRANDER, Elaine A, REEVES, Helen L, CHINNAIYAN, Arul M, RUBIN, Mark A, JIANFENG XU, THIBODEAU, Stephen N, FRIEDMAN, Scott L, MARTIGNETTI, John A, SCHAID, Daniel J, HIRSHFELD, Jennifer, HOD, Eldad, KATZ, Amanda, ISAACS, William B, HEBBRING, Scott, KOMIYA, Akira

“…Prostate cancer is a leading and increasingly prevalent cause of cancer death in men. Whereas family history of disease is one of the strongest prostate cancer…”
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Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer by Reeves, Helen L., Narla, Goutham, Ogunbiyi, Olagunju, Haq, Asif I., Katz, Amanda, Benzeno, Sharon, Hod, Eldad, Harpaz, Noam, Goldberg, Shlomit, Tal-Kremer, Sigal, Eng, Francis J., Arthur, Michael J.P., Martignetti, John A., Friedman, Scott L.

“…Background & Aims: Kruppel-like factor 6 (KLF6) is a ubiquitous zinc finger tumor suppressor that is often mutated in prostate cancer. Our aims were to…”
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Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1 by BENZENO, Sharon, NARLA, Goutham, ALLINA, Jorge, CHENG, George Z, REEVES, Helen L, BANCK, Michaela S, ODIN, Joseph A, DIEHL, J. Alan, GERMAIN, Doris, FRIEDMAN, Scott L

“…Kruppel-like factor 6 (KLF6) is a tumor suppressor gene inactivated in prostate and colon cancers, as well as in astrocytic gliomas. Here, we establish that…”
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Frequent inactivation of the tumor suppressor Kruppel‐like factor 6 (KLF6) in hepatocellular carcinoma by Kremer‐Tal, Sigal, Reeves, Helen L., Narla, Goutham, Thung, Swan N., Schwartz, Myron, Difeo, Analisa, Katz, Amanda, Bruix, Jordi, Bioulac‐Sage, Paulette, Martignetti, John A., Friedman, Scott L.

“…Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, reflecting incomplete characterization of underlying mechanisms and lack of early…”
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