Search Results - "Narkar, Vihang A."

Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function by Gallardo-Montejano, Violeta I., Saxena, Geetu, Kusminski, Christine M., Yang, Chaofeng, McAfee, John L., Hahner, Lisa, Hoch, Kathleen, Dubinsky, William, Narkar, Vihang A., Bickel, Perry E.

“…Dysfunctional cellular lipid metabolism contributes to common chronic human diseases, including type 2 diabetes, obesity, fatty liver disease and diabetic…”
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Interleukin-13 drives metabolic conditioning of muscle to endurance exercise by Knudsen, Nelson H, Stanya, Kristopher J, Hyde, Alexander L, Chalom, Mayer M, Alexander, Ryan K, Liou, Yae-Huei, Starost, Kyle A, Gangl, Matthew R, Jacobi, David, Liu, Sihao, Sopariwala, Danesh H, Fonseca-Pereira, Diogo, Li, Jun, Hu, Frank B, Garrett, Wendy S, Narkar, Vihang A, Ortlund, Eric A, Kim, Jonathan H, Paton, Chad M, Cooper, Jamie A, Lee, Chih-Hao

“…Repeated bouts of exercise condition muscle mitochondria to meet increased energy demand-an adaptive response associated with improved metabolic fitness. We…”
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Targeted ablation of Fn14 receptor improves exercise capacity and inhibits neurogenic muscle atrophy by Tomaz da Silva, Meiricris, Joshi, Aniket S., Koike, Tatiana E., Roy, Anirban, Mathukumalli, Kavya, Sopariwala, Danesh H., Narkar, Vihang A., Kumar, Ashok

“…Skeletal muscle atrophy is a prevalent complication in multiple chronic diseases and disuse conditions. Fibroblast growth factor‐inducible 14 (Fn14) is a…”
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Estrogen-Related Receptor Gamma Gene Therapy Promotes Therapeutic Angiogenesis and Muscle Recovery in Preclinical Model of PAD by Sopariwala, Danesh H, Rios, Andrea S, Saley, Addison, Kumar, Ashok, Narkar, Vihang A

“…Background Peripheral arterial disease and critical limb ischemia are cardiovascular complications associated with vascular insufficiency, oxidative metabolic…”
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Exercise and PGC-1α-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERRγ by Narkar, Vihang A., Fan, Weiwei, Downes, Michael, Yu, Ruth T., Jonker, Johan W., Alaynick, William A., Banayo, Ester, Karunasiri, Malith S., Lorca, Sabina, Evans, Ronald M.

“…How type I skeletal muscle inherently maintains high oxidative and vascular capacity in the absence of exercise is unclear. We show that nuclear receptor ERRγ…”
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Muscle Arnt/Hif1β Is Dispensable in Myofiber Type Determination, Vascularization and Insulin Sensitivity by Badin, Pierre-Marie, Sopariwala, Danesh H, Lorca, Sabina, Narkar, Vihang A

“…Aryl Hydrocarbon Receptor Nuclear Translocator/ hypoxia-inducible factor 1 beta (ARNT/ HIF1β), a member of bHLH-PAS family of transcriptional factors, plays a…”
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PGC1β Activates an Antiangiogenic Program to Repress Neoangiogenesis in Muscle Ischemia by Yadav, Vikas, Matsakas, Antonios, Lorca, Sabina, Narkar, Vihang A.

“…Revascularization of ischemic skeletal muscle is governed by a balance between pro- and antiangiogenic factors in multiple cell types but particularly in…”
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Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization[S] by Chao, Lily C., Wroblewski, Kevin, Ilkayeva, Olga R., Stevens, Robert D., Bain, James, Meyer, Gretchen A., Schenk, Simon, Martinez, Leonel, Vergnes, Laurent, Narkar, Vihang A., Drew, Brian G., Hong, Cynthia, Boyadjian, Rima, Hevener, Andrea L., Evans, Ronald M., Reue, Karen, Spencer, Melissa J., Newgard, Christopher B., Tontonoz, Peter

“…Mitochondrial dysfunction has been implicated in the pathogenesis of type 2 diabetes. Identifying novel regulators of mitochondrial bioenergetics will broaden…”
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Estrogen‐related receptor alpha is an AMPK‐regulated factor that promotes ischemic muscle revascularization and recovery in diet‐induced obese mice by Sopariwala, Danesh H., Rios, Andrea S., Park, Mi Kyung, Song, Min Sup, Kumar, Ashok, Narkar, Vihang A.

“…Obesity and type II diabetes are leading causes of peripheral arterial disease (PAD), which is characterized by vascular insufficiency and ischemic damage in…”
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Nuclear receptors as potential therapeutic targets in peripheral arterial disease and related myopathy by Kumar, Ashok, Narkar, Vihang A

“…Peripheral arterial disease (PAD) is a prevalent cardiovascular complication of limb vascular insufficiency, causing ischemic injury, mitochondrial metabolic…”
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Emerging role of TAK1 in the regulation of skeletal muscle mass by Roy, Anirban, Narkar, Vihang A., Kumar, Ashok

“…Maintenance of skeletal muscle mass and strength throughout life is crucial for heathy living and longevity. Several signaling pathways have been implicated in…”
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Ligands for FKBP12 Increase Ca2+ Influx and Protein Synthesis to Improve Skeletal Muscle Function by Lee, Chang Seok, Georgiou, Dimitra K., Dagnino-Acosta, Adan, Xu, Jianjun, Ismailov, Iskander I., Knoblauch, Mark, Monroe, Tanner O., Ji, RuiRui, Hanna, Amy D., Joshi, Aditya D., Long, Cheng, Oakes, Joshua, Tran, Ted, Corona, Benjamin T., Lorca, Sabina, Ingalls, Christopher P., Narkar, Vihang A., Lanner, Johanna T., Bayle, J. Henri, Durham, William J., Hamilton, Susan L.

“…Rapamycin at high doses (2–10 mg/kg body weight) inhibits mammalian target of rapamycin complex 1 (mTORC1) and protein synthesis in mice. In contrast, low…”
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PGC1α Promoter Methylation and Nucleosome Repositioning: Insights Into Exercise and Metabolic Regulation in Skeletal Muscle by Narkar, Vihang A

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Exercise and Ischemia-Activated Pathways in Limb Muscle Angiogenesis and Vascular Regeneration by Narkar, Vihang A

“…Exercise has a profound effect on cardiovascular disease, particularly through vascular remodeling and regeneration. Peripheral artery disease (PAD) is one…”
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Estrogen‐related receptor α is involved in angiogenesis and skeletal muscle revascularization in hindlimb ischemia by Sopariwala, Danesh H., Likhite, Neah, Pei, Gungsheng, Haroon, Fnu, Lin, Lisa, Yadav, Vikas, Zhao, Zhongming, Narkar, Vihang A.

“…Skeletal muscle ischemia is a major consequence of peripheral arterial disease (PAD) or critical limb ischemia (CLI). Although therapeutic options for…”
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TAK1 preserves skeletal muscle mass and mitochondrial function through redox homeostasis by Roy, Anirban, Sharma, Aditya K., Nellore, Kushal, Narkar, Vihang A, Kumar, Ashok

“…Skeletal muscle atrophy is debilitating consequence of a large number of chronic disease states, aging, and disuse conditions. Skeletal muscle mass is…”
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PPAR delta: a dagger in the heart of the metabolic syndrome by Barish, Grant D, Narkar, Vihang A, Evans, Ronald M

“…Obesity is a growing threat to global health by virtue of its association with insulin resistance, glucose intolerance, hypertension, and dyslipidemia,…”
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Innately expressed estrogen‐related receptors in the skeletal muscle are indispensable for exercise fitness by Sopariwala, Danesh H., Rios, Andrea S., Pei, Guangsheng, Roy, Anirban, Tomaz da Silva, Meiricris, Thi Thu Nguyen, Hao, Saley, Addison, Van Drunen, Rachel, Kralli, Anastasia, Mahan, Kristin, Zhao, Zhongming, Kumar, Ashok, Narkar, Vihang A.

“…Transcriptional determinants in the skeletal muscle that govern exercise capacity, while poorly defined, could provide molecular insights into how exercise…”
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Revascularization of Ischemic Skeletal Muscle by Estrogen-Related Receptor-γ by Matsakas, Antonios, Yadav, Vikas, Lorca, Sabina, Evans, Ronald M, Narkar, Vihang A

“…RATIONALE:Oxidative myofibers in the skeletal muscles express high levels of angiogenic factors, have dense vasculature, and promptly revascularize during…”
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GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer by Bhat, Raksha R., Yadav, Puja, Sahay, Debashish, Bhargava, Dharmendra K., Creighton, Chad J., Yazdanfard, Sahar, Al-rawi, Ahmed, Yadav, Vikas, Qin, Lanfang, Nanda, Sarmistha, Sethunath, Vidyalakshmi, Fu, Xiaoyong, De Angelis, Carmine, Narkar, Vihang A., Osborne, C. Kent, Schiff, Rachel, Trivedi, Meghana V.

“…Purpose G protein-coupled receptors (GPCRs) represent the largest family of druggable targets in human genome. Although several GPCRs can cross-talk with the…”
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