Search Results - "Nariya, Maulik K"

Crosstalk and ultrasensitivity in protein degradation pathways by Mallela, Abhishek, Nariya, Maulik K, Deeds, Eric J

“…Protein turnover is vital to cellular homeostasis. Many proteins are degraded efficiently only after they have been post-translationally "tagged" with a…”
Get full text

Proteomic profiling across breast cancer cell lines and models by Kalocsay, Marian, Berberich, Matthew J., Everley, Robert A., Nariya, Maulik K., Chung, Mirra, Gaudio, Benjamin, Victor, Chiara, Bradshaw, Gary A., Eisert, Robyn J., Hafner, Marc, Sorger, Peter K., Mills, Caitlin E., Subramanian, Kartik

“…We performed quantitative proteomics on 60 human-derived breast cancer cell line models to a depth of ~13,000 proteins. The resulting high-throughput datasets…”
Get full text

Mathematical Model for Length Control by the Timing of Substrate Switching in the Type III Secretion System by Nariya, Maulik K, Israeli, Johnny, Shi, Jack J, Deeds, Eric J

“…Type III Secretion Systems (T3SS) are complex bacterial structures that provide gram-negative pathogens with a unique virulence mechanism whereby they grow a…”
Get full text

Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer by Lin, Jia-Ren, Wang, Shu, Coy, Shannon, Chen, Yu-An, Yapp, Clarence, Tyler, Madison, Nariya, Maulik K., Heiser, Cody N., Lau, Ken S., Santagata, Sandro, Sorger, Peter K.

“…Advanced solid cancers are complex assemblies of tumor, immune, and stromal cells characterized by high intratumoral variation. We use highly multiplexed…”
Get full text

MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging by Schapiro, Denis, Sokolov, Artem, Yapp, Clarence, Chen, Yu-An, Muhlich, Jeremy L., Hess, Joshua, Creason, Allison L., Nirmal, Ajit J., Baker, Gregory J., Nariya, Maulik K., Lin, Jia-Ren, Maliga, Zoltan, Jacobson, Connor A., Hodgman, Matthew W., Ruokonen, Juha, Farhi, Samouil L., Abbondanza, Domenic, McKinley, Eliot T., Persson, Daniel, Betts, Courtney, Sivagnanam, Shamilene, Regev, Aviv, Goecks, Jeremy, Coffey, Robert J., Coussens, Lisa M., Santagata, Sandro, Sorger, Peter K.

“…Highly multiplexed tissue imaging makes detailed molecular analysis of single cells possible in a preserved spatial context. However, reproducible analysis of…”
Get full text

Robustness and the evolution of length control strategies in the T3SS and flagellar hook by Nariya, Maulik K., Mallela, Abhishek, Shi, Jack J., Deeds, Eric J.

“…Bacterial cells construct many structures, such as the flagellar hook and the type III secretion system (T3SS) injectisome, that aid in crucial physiological…”
Get full text

Paired evaluation of machine-learning models characterizes effects of confounders and outliers by Nariya, Maulik K., Mills, Caitlin E., Sorger, Peter K., Sokolov, Artem

“…The true accuracy of a machine-learning model is a population-level statistic that cannot be observed directly. In practice, predictor performance is estimated…”
Get full text

The Botanical Drug Substance Crofelemer as a Model System for Comparative Characterization of Complex Mixture Drugs by Kleindl, Peter A, Xiong, Jian, Hewarathna, Asha, Mozziconacci, Olivier, Nariya, Maulik K, Fisher, Adam C, Deeds, Eric J, Joshi, Sangeeta B, Middaugh, C Russell, Schöneich, Christian, Volkin, David B, Forrest, M Laird

“…Crofelemer is a botanical polymeric proanthocyanidin that inhibits chloride channel activity and is used clinically for treating HIV-associated secretory…”
Get more information

Chemical Stability of the Botanical Drug Substance Crofelemer: A Model System for Comparative Characterization of Complex Mixture Drugs by Hewarathna, Asha, Mozziconacci, Olivier, Nariya, Maulik K, Kleindl, Peter A, Xiong, Jian, Fisher, Adam C, Joshi, Sangeeta B, Middaugh, C Russell, Forrest, M Laird, Volkin, David B, Deeds, Eric J, Schöneich, Christian

“…As the second of a 3-part series of articles in this issue concerning the development of a mathematical model for comparative characterization of complex…”
Get more information

Comparative Characterization of Crofelemer Samples Using Data Mining and Machine Learning Approaches With Analytical Stability Data Sets by Nariya, Maulik K, Kim, Jae Hyun, Xiong, Jian, Kleindl, Peter A, Hewarathna, Asha, Fisher, Adam C, Joshi, Sangeeta B, Schöneich, Christian, Forrest, M Laird, Middaugh, C Russell, Volkin, David B, Deeds, Eric J

“…There is growing interest in generating physicochemical and biological analytical data sets to compare complex mixture drugs, for example, products from…”
Get more information

Erratum: Paired evaluation of machine-learning models characterizes effects of confounders and outliers by Nariya, Maulik K, Mills, Caitlin E, Sorger, Peter K, Sokolov, Artem

Get full text

Paired evaluation of machine-learning models characterizes effects of confounders and outliers by Nariya, Maulik K., Mills, Caitlin E., Sorger, Peter K., Sokolov, Artem

Get full text