Search Results - "Narita, Michiko"

Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer by Watanabe, Moe, Narita, Michiko, Hamada, Yusuke, Yamashita, Akira, Tamura, Hideki, Ikegami, Daigo, Kondo, Takashige, Shinzato, Tatsuto, Shimizu, Takatsune, Fukuchi, Yumi, Muto, Akihiro, Okano, Hideyuki, Yamanaka, Akihiro, Tawfik, Vivianne L, Kuzumaki, Naoko, Navratilova, Edita, Porreca, Frank, Narita, Minoru

“…Chronic pain induced by nerve damage due to trauma or invasion of cancer to the bone elicits severe ongoing pain as well as hyperalgesia and allodynia likely…”
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Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic pain by Yamashita, Akira, Hamada, Asami, Suhara, Yuki, Kawabe, Rui, Yanase, Makoto, Kuzumaki, Naoko, Narita, Michiko, Matsui, Ryosuke, Okano, Hideyuki, Narita, Minoru

“…ABSTRACT Insomnia, depression, and anxiety disorder are common problems for people with neuropathic pain. In this study, mild noxious heat stimuli increased…”
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Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain by IMAI, Satoshi, IKEGAMI, Daigo, KATO, Akira, NAKAMURA, Atsushi, ARAKI, Akiko, OMI, Kazuo, NAKAMURA, Masaya, OKANO, Hirotakijames, OKANO, Hideyuki, ANDO, Takayuki, TAKESHIMA, Hideyuki, USHIJIMA, Toshikazu, YAMASHITA, Akira, KUZUMAKI, Naoko, SUZUKI, Tsutomu, NARITA, Minoru, SHIMIZU, Toshikazu, NARITA, Michiko, NIIKURA, Keiichi, FURUYA, Masaharu, KOBAYASHI, Yasuhisa, MIYASHITA, Kazuhiko, OKUTSU, Daiki

“…A multiplex analysis for profiling the expression of candidate genes along with epigenetic modification may lead to a better understanding of the complex…”
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Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment by Kuzumaki, Naoko, Ikegami, Daigo, Tamura, Rie, Hareyama, Nana, Imai, Satoshi, Narita, Michiko, Torigoe, Kazuhiro, Niikura, Keiichi, Takeshima, Hideyuki, Ando, Takayuki, Igarashi, Katsuhide, Kanno, Jun, Ushijima, Toshikazu, Suzuki, Tsutomu, Narita, Minoru

“…Environmental enrichment is an experimental paradigm that increases brain‐derived neurotrophic factor (BDNF) gene expression accompanied by neurogenesis in the…”
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Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors by Suda, Yukari, Nakamura, Keiko, Matsuyama, Fukiko, Hamada, Yusuke, Makabe, Hitoshi, Narita, Michiko, Nagumo, Yasuyuki, Mori, Tomohisa, Kuzumaki, Naoko, Narita, Minoru

“…While the excessive inflammation in cancer cachexia is well-known to be induced by the overproduction of inflammatory mediators in the periphery, microflora…”
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Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons by Sato, Daisuke, Narita, Michiko, Hamada, Yusuke, Mori, Tomohisa, Tanaka, Kenichi, Tamura, Hideki, Yamanaka, Akihiro, Matsui, Ryosuke, Watanabe, Dai, Suda, Yukari, Senba, Emiko, Watanabe, Moe, Navratilova, Edita, Porreca, Frank, Kuzumaki, Naoko, Narita, Minoru

“…Emerging evidence suggests that the mesolimbic dopaminergic network plays a role in the modulation of pain. As chronic pain conditions are associated with…”
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Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease by Kuzumaki, Naoko, Suda, Yukari, Iwasawa, Chizuru, Narita, Michiko, Sone, Takefumi, Watanabe, Moe, Maekawa, Aya, Matsumoto, Takuya, Akamatsu, Wado, Igarashi, Katsuhide, Tamura, Hideki, Takeshima, Hideyuki, Tawfik, Vivianne L, Ushijima, Toshikazu, Hattori, Nobutaka, Okano, Hideyuki, Narita, Minoru

“…The mechanism by which dopaminergic neurons are selectively affected in Parkinson's disease is not fully understood. In this study, we found a dramatic…”
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Endocan as a prognostic biomarker of triple-negative breast cancer by Sagara, Atsunobu, Igarashi, Katsuhide, Otsuka, Maky, Kodama, Akihiro, Yamashita, Mutsumi, Sugiura, Rei, Karasawa, Takeshi, Arakawa, Kazuhiko, Narita, Michiko, Kuzumaki, Naoko, Narita, Minoru, Kato, Yoshinori

“…Purpose Triple-negative breast cancer (TNBC) has aggressive characteristics and fewer treatment options than other subtypes. The purpose of this study was to…”
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Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson's disease-like motor dysfunction by Suda, Yukari, Kuzumaki, Naoko, Sone, Takefumi, Narita, Michiko, Tanaka, Kenichi, Hamada, Yusuke, Iwasawa, Chizuru, Shibasaki, Masahiro, Maekawa, Aya, Matsuo, Miri, Akamatsu, Wado, Hattori, Nobutaka, Okano, Hideyuki, Narita, Minoru

“…Ghrelin exerts a wide range of physiological actions throughout the body and appears to be a promising target for disease therapy. Endogenous ghrelin receptors…”
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Chronic treatment of non-small-cell lung cancer cells with gefitinib leads to an epigenetic loss of epithelial properties associated with reductions in microRNA-155 and -200c by Narita, Michiko, Shimura, Eri, Nagasawa, Atsumi, Aiuchi, Toshiki, Suda, Yukari, Hamada, Yusuke, Ikegami, Daigo, Iwasawa, Chizuru, Arakawa, Kazuhiko, Igarashi, Katsuhide, Kuzumaki, Naoko, Yoshioka, Yusuke, Ochiya, Takahiro, Takeshima, Hideyuki, Ushijima, Toshikazu, Narita, Minoru

“…The EGFR tyrosine kinase inhibitor gefitinib is used in therapy for non-small-cell lung cancer (NSCLC). However, its application is limited by…”
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Intrinsic Resistance to 5-Fluorouracil in a Brain Metastatic Variant of Human Breast Cancer Cell Line, MDA-MB-231BR by Sagara, Atsunobu, Igarashi, Katsuhide, Otsuka, Maky, Karasawa, Takeshi, Gotoh, Noriko, Narita, Michiko, Kuzumaki, Naoko, Narita, Minoru, Kato, Yoshinori

“…Although drug resistance is often observed in metastatic recurrence of breast cancer, little is known about the intrinsic drug resistance in such metastases…”
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Direct Evidence of Astrocytic Modulation in the Development of Rewarding Effects Induced by Drugs of Abuse by NARITA, Minoru, MIYATAKE, Mayumi, NARITA, Michiko, SHIBASAKI, Masahiro, SHINDO, Keiko, NAKAMURA, Atsushi, KUZUMAKI, Naoko, NAGUMO, Yasuyuki, SUZUKI, Tsutomu

“…Long-term exposure to pyschostimulants and opioids induced neuronal plasticity. Accumulating evidence suggests that astrocytes actively participate in synaptic…”
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Cancer aggravation due to persistent pain signals with the increased expression of pain-related mediators in sensory neurons of tumor-bearing mice by Tanaka, Kenichi, Kondo, Takashige, Narita, Michiko, Muta, Takeru, Yoshida, Sara, Sato, Daisuke, Suda, Yukari, Hamada, Yusuke, Shimizu, Takatsune, Kuzumaki, Naoko, Narita, Minoru

“…A growing body of evidence suggests that intractable pain reduces both the quality of life and survival in cancer patients. In the present study, we evaluated…”
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Changes in the expression of IL-6-Mediated MicroRNAs in the dorsal root ganglion under neuropathic pain in mice by Hori, Naosuke, Narita, Michiko, Yamashita, Akira, Horiuchi, Hiroshi, Hamada, Yusuke, Kondo, Takashige, Watanabe, Moe, Igarashi, Katsuhide, Kawata, Miho, Shibasaki, Masahiro, Yamazaki, Mitsuaki, Kuzumaki, Naoko, Inada, Eiichi, Ochiya, Takahiro, Iseki, Masako, Mori, Tomohisa, Narita, Minoru

“…A multiplex analysis for profiling the expression of candidate microRNAs (miRNAs), which are small noncoding RNAs that function as key post‐transcriptional…”
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Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus by Yoshida, Sara, Hamada, Yusuke, Narita, Michiko, Sato, Daisuke, Tanaka, Kenichi, Mori, Tomohisa, Tezuka, Hiroyuki, Suda, Yukari, Tamura, Hideki, Aoki, Kazunori, Kuzumaki, Naoko, Narita, Minoru

“…A growing body of evidence suggests that excess stress could aggravate tumor progression. The paraventricular nucleus (PVN) of the hypothalamus plays an…”
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Tumor suppression and improvement in immune systems by specific activation of dopamine D1-receptor-expressing neurons in the nucleus accumbens by Sato, Daisuke, Hamada, Yusuke, Narita, Michiko, Mori, Tomohisa, Tezuka, Hiroyuki, Suda, Yukari, Tanaka, Kenichi, Yoshida, Sara, Tamura, Hideki, Yamanaka, Akihiro, Senba, Emiko, Kuzumaki, Naoko, Narita, Minoru

“…Recent research has suggested that the mesolimbic dopamine network that mainly terminates in the nucleus accumbens may positively control the peripheral immune…”
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Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors by Suda, Yukari, Kuzumaki, Naoko, Narita, Michiko, Hamada, Yusuke, Shibasaki, Masahiro, Tanaka, Kenichi, Tamura, Hideki, Kawamura, Takashi, Kondo, Takashige, Yamanaka, Akihiro, Narita, Minoru

“…Ghrelin plays roles in a wide range of central functions by activating the growth hormone secretagogue receptor (GHSR). This receptor has recently been found…”
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Analyses of the possible anti-tumor effect of yokukansan by Han, Cheolsun, Kawata, Miho, Hamada, Yusuke, Kondo, Takashige, Wada, Junna, Asano, Katsunori, Makabe, Hitoshi, Igarashi, Katsuhide, Kuzumaki, Naoko, Narita, Michiko, Kobayashi, Hiroyuki, Narita, Minoru

“…The Kampo medicine yokukansan (YKS) has a wide variety of properties such as anxiolytic, anti-inflammatory and analgesic effects, and is also thought to…”
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Histone modification of pain-related gene expression in spinal cord neurons under a persistent postsurgical pain-like state by electrocautery by Katsuda, Yosuke, Tanaka, Kenichi, Mori, Tomohisa, Narita, Michiko, Takeshima, Hideyuki, Kondo, Takashige, Yamabe, Yoshiyuki, Matsufuji, Misa, Sato, Daisuke, Hamada, Yusuke, Yamaguchi, Keisuke, Ushijima, Toshikazu, Inada, Eiichi, Kuzumaki, Naoko, Iseki, Masako, Narita, Minoru

“…Chronic postsurgical pain (CPSP) is a serious problem. We developed a mouse model of CPSP induced by electrocautery and examined the mechanism of CPSP. In this…”
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Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system by Watanabe, Moe, Sugiura, Yuki, Sugiyama, Eiji, Narita, Michiko, Navratilova, Edita, Kondo, Takashige, Uchiyama, Naohiko, Yamanaka, Akihiro, Kuzumaki, Naoko, Porreca, Frank, Narita, Minoru

“…Various small molecules act as neurotransmitters and orchestrate neural communication. Growing evidence suggests that not only classical neurotransmitters but…”
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