Search Results - "Nariai, Tetsuro"

SM-368229, a Novel Selective and Potent Non-steroidal Mineralocorticoid Receptor Antagonist With Strong Urinary Na+ Excretion Activity by Nariai, Tetsuro, Fujita, Katsuya, Mori, Masaya, Katayama, Seiji, Hori, Seiji, Matsui, Kazuki

“…Mineralocorticoid receptor (MR) antagonists, such as spironolactone (SPI) and eplerenone (EPL), are useful for the treatment of hypertension and heart failure…”
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Application of Zwitterionic Polymer Hydrogels to Optical Tissue Clearing for 3D Fluorescence Imaging by Kojima, Chie, Koda, Takayuki, Nariai, Tetsuro, Ichihara, Junji, Sugiura, Kikuya, Matsumoto, Akikazu

“…Zwitterionic polymers have both anion and cation groups in the side chain and have been used in various biomedical applications because of the unique…”
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Application of Zwitterionic Polymer Hydrogels to Optical Tissue Clearing for 3D Fluorescence Imaging by Kojima, Chie, Koda, Takayuki, Nariai, Tetsuro, Ichihara, Junji, Sugiura, Kikuya, Matsumoto, Akikazu

“…Front Cover: This picture shows the optical clearing process of a brain tissue to visualize the 3D vascular network in fluorescence imaging. Zwitterionic…”
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Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors by Takai, Kentaro, Chiyo, Naoki, Nakajima, Tomoko, Nariai, Tetsuro, Ishikawa, Chihiro, Nakatani, Shogo, Ikeno, Akihisa, Yamamoto, Setsuko, Sone, Toshihiko

“…We have previously reported a series of cyclopropyl urea derivatives as potent orally available soluble epoxide hydrolase (sEH) inhibitors. Here, we designed…”
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Atrogin-1 ubiquitin ligase is upregulated by doxorubicin via p38-MAP kinase in cardiac myocytes by Yamamoto, Yasuhiro, Hoshino, Yuki, Ito, Takashi, Nariai, Tetsuro, Mohri, Tomomi, Obana, Masanori, Hayata, Nozomi, Uozumi, Yoriko, Maeda, Makiko, Fujio, Yasushi, Azuma, Junichi

“…Aims Doxorubicin (DOX) is one of the most effective anti-neoplastic agents; however, its clinical use is limited by drug-induced cardiomyopathy. The molecular…”
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SM-368229, a Novel Promising Mineralocorticoid Receptor Antagonist, Shows Antihypertensive Efficacy With Minimal Effect on Serum Potassium Level in Rats by Nariai, Tetsuro, Fujita, Katsuya, Mori, Masaya, Katayama, Seiji, Hori, Seiji, Matsui, Kazuki

“…The purpose of this study was to evaluate the effects of SM-368229, a novel mineralocorticoid receptor (MR) antagonist with partial agonistic activity, and…”
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DSR-71167, a novel mineralocorticoid receptor antagonist with carbonic anhydrase inhibitory activity, separates urinary sodium excretion and serum potassium elevation in rats by Nariai, Tetsuro, Fujita, Katsuya, Kawane, Kenji, Mori, Masaya, Nakayama, Ryo, Matsuda, Koichi, Katayama, Seiji, Fukuda, Nobuhisa, Hori, Seiji, Iwata, Masato, Hasegawa, Futoshi, Suzuki, Kuniko, Kato, Hiroshi

“…Mineralocorticoid receptor (MR) antagonists, such as spironolactone (SPI) and eplerenone (EPL), are useful for treating hypertension and heart failure…”
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Abstract 9409: DSR-85955, a Novel Mineralocorticoid Receptor Antagonist With Carbonic Anhydrase Inhibitory Activity, Exhibits Low Hyperkalemia Risk in Rats by Kato, Hiroshi, Mori, Masaya, Masakazu, Shintome, Nariai, Tetsuro, Katayama, Seiji, Hori, Seiji, Hasegawa, Futoshi, Suzuki, Kuniko, Fujita, Katsuya

“…Abstract only Background: Mineralocorticoid receptor (MR) antagonists, such as spironolactone and eplerenone, are useful for the treatment of hypertension and…”
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Structure-based optimization of cyclopropyl urea derivatives as potent soluble epoxide hydrolase inhibitors for potential decrease of renal injury without hypotensive action by Takai, Kentaro, Nakajima, Tomoko, Takanashi, Yosuke, Sone, Toshihiko, Nariai, Tetsuro, Chiyo, Naoki, Nakatani, Shogo, Ishikawa, Chihiro, Yamaguchi, Nobuyuki, Fujita, Katsuya, Yamada, Kazuto

“…Epoxyeicosatrienoic acids (EETs) are known to have beneficial pharmacological effects on various cardiovascular events. However, EETs are biologically…”
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Antihypertensive and cardiorenal protective effects of SM-368229, a novel mineralocorticoid receptor antagonist, in aldosterone/salt-treated rats by Nariai, Tetsuro, Fujita, Katsuya, Mori, Masaya, Katayama, Seiji, Hori, Seiji, Matsui, Kazuki

“…The purpose of this study was to evaluate the effects of SM-368229, a novel mineralocorticoid receptor (MR) antagonist, on the blood pressure and cardiorenal…”
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449 SM-368229, A MINERALOCORTICOID RECEPTOR ANTAGONIST WITH MODERATE PARTIAL AGONISTIC ACTIVITY SHOWS ANTI-HYPERTENSIVE EFFICACY WITH MINIMAL EFFECT ON SERUM POTASSIUM LEVEL IN RATS by Nagano, Hiromichi, Nariai, Tetsuro, Fujita, Katsuya, Mori, Masaya, Katayama, Seiji, Hori, Seiji

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Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages by Sumita, Chinuyo, Yamane, Masako, Matsuda, Takahisa, Maeda, Makiko, Nariai, Tetsuro, Fujio, Yasushi, Azuma, Junichi

“…In the process of atherosclerosis, platelet activating factor (PAF) promotes the infiltration of inflammatory cells into atherosclerotic plaque by modulating…”
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Taurine transporter is transcriptionally regulated through MEF2 during skeletal muscle differentiation by Yoriko Uozumi, Yasushi Fujio, Takashi Ito, Satoko Muraoka, Takahisa Matsuda, Tetsuro Nariai, Tomomi Mohri, Yasushi Kimura, Kyoko Takahashi, Junichi Azuma

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