Chronic restraint stress during withdrawal increases vulnerability to drug priming-induced cocaine seeking via a dopamine D1-like receptor-mediated mechanism

•The effect of chronic restraint stress on subsequent cocaine seeking was tested.•Both extinction- and abstinence-based animal relapse models were used.•Chronic restraint stress caused increase in cocaine priming-induced reinstatement.•A dopamine D1-like receptor antagonist, combined with stress, at...

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Bibliographic Details
Published in:	Drug and alcohol dependence Vol. 187; pp. 327 - 334
Main Authors:	Ball, Kevin T., Stone, Eric, Best, Olivia, Collins, Tyler, Edson, Hunter, Hagan, Erin, Nardini, Salvatore, Neuciler, Phelan, Smolinsky, Michael, Tosh, Lindsay, Woodlen, Kristin
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01-06-2018 Elsevier Science Ltd
Subjects:	Abstinence Addictions Animal models Animals Benzazepines - administration & dosage Cocaine Cocaine - administration & dosage Cocaine-Related Disorders - psychology Cues Disease Models, Animal Dopamine Dopamine Antagonists - administration & dosage Dopamine D1 receptors Drug abuse Drug addiction Drug self-administration Drug withdrawal Drug-Seeking Behavior - drug effects Extinction Extinction, Psychological - drug effects Hostility Induced Male Management Narcotics Occupational stress Priming Psychological extinction Rats Rats, Sprague-Dawley Receptors Receptors, Dopamine D1 - antagonists & inhibitors Reinstatement Relapse Repetition Priming - drug effects Restraint, Physical - psychology Self Administration Stress Stress, Psychological - psychology Stresses Vulnerability Withdrawal CS mPFC Relapse IL Dopamine D1R Reinstatement Cocaine FR Abstinence Stress MDMA
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Summary:	•The effect of chronic restraint stress on subsequent cocaine seeking was tested.•Both extinction- and abstinence-based animal relapse models were used.•Chronic restraint stress caused increase in cocaine priming-induced reinstatement.•A dopamine D1-like receptor antagonist, combined with stress, attenuated this effect.•Prior antagonist treatment resulted in increased cue-induced reinstatement. A major obstacle in the treatment of individuals with cocaine addiction is their high propensity for relapse. Although the clinical scenario of acute stress-induced relapse has been well studied in animal models, few pre-clinical studies have investigated the role of chronic stress in relapse or the interaction between chronic stress and other relapse triggers. We tested the effect of chronic restraint stress on cocaine seeking in rats using both extinction- and abstinence-based animal relapse models. Rats were trained to press a lever for I.V. cocaine infusions (0.50 mg/kg/infusion) paired with a discrete tone + light cue in daily 3-h sessions. Following self-administration, rats were exposed to a chronic restraint stress procedure (3 h/day) or control procedure (unstressed) during the first seven days of a 13-day extinction period during which lever presses had no programmed consequences. This was followed by cue- and cocaine priming-induced drug seeking tests. In a separate group of rats, cocaine seeking was assessed during forced abstinence both before and after the same chronic stress procedure. A history of chronic restraint stress was associated with increased cocaine priming-induced drug seeking, an effect attenuated by co-administration of SCH-23390 (10.0 μg/kg; i.p.), a dopamine D1-like receptor antagonist, with daily restraint. Repeated SCH-23390 administration but not stress during extinction increased cue-induced reinstatement. Exposure to chronic stress during early withdrawal may confer lasting vulnerability to some types of relapse, and dopamine D1-like receptors appear to mediate both chronic stress effects on cocaine seeking and extinction of cocaine seeking.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0376-8716 1879-0046
DOI:	10.1016/j.drugalcdep.2018.03.024