Search Results - "Narayanaswamy, Rohini"

Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase by Padyana, Anil K., Gross, Stefan, Jin, Lei, Cianchetta, Giovanni, Narayanaswamy, Rohini, Wang, Feng, Wang, Rui, Fang, Cheng, Lv, Xiaobing, Biller, Scott A., Dang, Lenny, Mahoney, Christopher E., Nagaraja, Nelamangala, Pirman, David, Sui, Zhihua, Popovici-Muller, Janeta, Smolen, Gromoslaw A.

“…Squalene epoxidase (SQLE), also known as squalene monooxygenase, catalyzes the stereospecific conversion of squalene to 2,3( S )-oxidosqualene, a key step in…”
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A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition by Mahoney, Christopher E., Pirman, David, Chubukov, Victor, Sleger, Taryn, Hayes, Sebastian, Fan, Zi Peng, Allen, Eric L., Chen, Ying, Huang, Lingling, Liu, Meina, Zhang, Yingjia, McDonald, Gabrielle, Narayanaswamy, Rohini, Choe, Sung, Chen, Yue, Gross, Stefan, Cianchetta, Giovanni, Padyana, Anil K., Murray, Stuart, Liu, Wei, Marks, Kevin M., Murtie, Joshua, Dorsch, Marion, Jin, Shengfang, Nagaraja, Nelamangala, Biller, Scott A., Roddy, Thomas, Popovici-Muller, Janeta, Smolen, Gromoslaw A.

“…Aberrant metabolism of cancer cells is well appreciated, but the identification of cancer subsets with specific metabolic vulnerabilities remains challenging…”
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Quantitation of uridine and L-dihydroorotic acid in human plasma by LC–MS/MS using a surrogate matrix approach by Yin, Feng, Ling, Yonghua, Martin, Jason, Narayanaswamy, Rohini, McIntosh, Lisa, Li, Fumin, Liu, Guowen

“…•A validated LC–MS/MS assay for the quantitation of endogenous analytes, Uridine and L-Dihydroorotic Acid, in human plasma.•A surrogate matrix approach with…”
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Enasidenib-induced differentiation promotes sensitivity to venetoclax in IDH2-mutated acute myeloid leukemia by Cathelin, Severine, Sharon, David, Subedi, Amit, Cojocari, Dan, Phillips, Darren C., Leverson, Joel D., MacBeth, Kyle J., Nicolay, Brandon, Narayanaswamy, Rohini, Ronseaux, Sebastien, Liu, Guowen, Chan, Steven M.

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Simultaneous determination of oxysterols, cholesterol and 25-hydroxy-vitamin D3 in human plasma by LC-UV-MS by Narayanaswamy, Rohini, Iyer, Vignesh, Khare, Prachi, Bodziak, Mary Lou, Badgett, Darlene, Zivadinov, Robert, Weinstock-Guttman, Bianca, Rideout, Todd C, Ramanathan, Murali, Browne, Richard W

“…Oxysterols are promising biomarkers of neurodegenerative diseases that are linked with cholesterol and vitamin D metabolism. There is an unmet need for methods…”
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Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice by Hao, Zhenyue, Cairns, Rob A., Inoue, Satoshi, Li, Wanda Y., Sheng, Yi, Lemonnier, François, Wakeham, Andrew, Snow, Bryan E., Dominguez-Brauer, Carmen, Ye, Jing, Larsen, Dana M., Straley, Kimberly S., Tobin, Erica R., Narayanaswamy, Rohini, Gaulard, Philippe, Mak, Tak W.

“…Gain-of-function mutations in isocitrate dehydrogenase 1 (IDH1) are key drivers of hematopoietic malignancies. Although these mutations are most commonly…”
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Abstract 1339: Investigations into rational combination approaches with ivosidenib in a mutant IDH1 acute myeloid leukemia patient-derived xenograft model by Hudson, Christine, Narayanaswamy, Rohini, Ronseaux, Sebastien, Bowden, Chris, Nicolay, Brandon

“…Abstract Background: Somatic mutations in isocitrate dehydrogenase 1 (IDH1) arise in roughly 6-10% of patients with acute myeloid leukemia (AML). These…”
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The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model by Matte, Alessandro, Federti, Enrica, Kung, Charles, Kosinski, Penelope A, Narayanaswamy, Rohini, Russo, Roberta, Federico, Giorgia, Carlomagno, Francesca, Desbats, Maria Andrea, Salviati, Leonardo, Leboeuf, Christophe, Valenti, Maria Teresa, Turrini, Francesco, Janin, Anne, Yu, Shaoxia, Beneduce, Elisabetta, Ronseaux, Sebastien, Iatcenko, Iana, Dang, Lenny, Ganz, Tomas, Jung, Chun-Ling, Iolascon, Achille, Brugnara, Carlo, De Franceschi, Lucia

“…Anemia in β-thalassemia is related to ineffective erythropoiesis and reduced red cell survival. Excess free heme and accumulation of unpaired α-globin chains…”
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Quantitation of ivosidenib in human plasma via LC–MS/MS and its application in clinical trials by Yin, Feng, Yu, Shaoxia, Narayanaswamy, Rohini, Mangus, Heidi, McCourt, Erin, Liu, Guowen

“…Ivosidenib is a potent and selective small molecule inhibitor of mutant isocitrate dehydrogenase 1. Accurate measurement of ivosidenib is the key to ivosidenib…”
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The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development by Lemonnier, François, Cairns, Rob A., Inoue, Satoshi, Li, Wanda Y., Dupuy, Aurelie, Broutin, Sophie, Martin, Nadine, Fataccioli, Virginie, Pelletier, Romain, Wakeham, Andrew, Snow, Bryan E., de Leval, Laurence, Pujals, Anais, Haioun, Corinne, Paci, Angelo, Tobin, Erica R., Narayanaswamy, Rohini, Yen, Katherine, Jin, Shengfang, Gaulard, Philippe, Mak, Tak W.

“…Oncogenic isocitrate dehydrogenase (IDH)1 and IDH2 mutations at three hotspot arginine residues cause an enzymatic gain of function that leads to the…”
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Abstract 3607: Inhibition of mutant IDH enzymes reduces production of 2-HG but does not restore wild type IDH activity in vitro or in vivo by Sellers, Katie, Sleger, Taryn, Ronseaux, Sebastien, Narayanaswamy, Rohini, Hudson, Christine, Roddy, Thomas, Nicolay, Brandon

“…Abstract Mutations in isocitrate dehydrogenase (IDH) 1 and 2 occur in variety of malignancies, and notably >70% of low grade gliomas. These mutations lead to…”
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EXTH-15. INHIBITION OF 2-HG LEADS TO UPREGULATION OF A PRO-INFLAMMATORY GENE SIGNATURE IN A NOVEL HLA-A2/HLA-DR1 TRANSGENIC MOUSE MODEL OF IDH1R132H-EXPRESSING GLIOMA by Chuntova, Polly, Nicolay, Brandon, Hudson, Christine, Narayanaswamy, Rohini, Ronseaux, Sebastien, Montoya, Megan, Downey, Kira, Okada, Hideho

“…Abstract Recent studies have demonstrated the impacts of 2-HG on the anti-tumor immune response in isocitrate dehydrogenase (IDH)-mutant gliomas. Our…”
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Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis by Herron, Josi, Reese, Rosalyn C, Tallman, Keri A, Narayanaswamy, Rohini, Porter, Ned A, Xu, Libin

“…In this study, we aim to identify environmental molecules that can inhibit cholesterol biosynthesis, potentially leading to the same biochemical defects as…”
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2031 - DELINEATING MECHANISMS OF ACQUIRED RESISTANCE TO IDH INHIBITORS IN AML by Kats, Lev, Gruber, Emily, Narayanaswamy, Rohini, Ronseaux, Sebastien, Nicolay, Brandon, Johnstone, Ricky

“…Approximately 20% of acute myeloid leukaemia (AML) patients carry mutations in genes that encode the metabolic enzymes isocitrate dehydrogenase (IDH) 1 and -2…”
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Preclinical toxicology profile of squalene epoxidase inhibitors by Nagaraja, Raj, Olaharski, Andrew, Narayanaswamy, Rohini, Mahoney, Christopher, Pirman, David, Gross, Stefan, Roddy, Thomas P., Popovici-Muller, Janeta, Smolen, Gromoslaw A., Silverman, Lee

“…Small cell lung cancer (SCLC) is a particularly aggressive subset of lung cancer, and identification of new therapeutic options is of significant interest. We…”
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Abstract 3510: IDH1-R132H tumor cells are not robustly sensitive to PARP inhibition in a 2-HG dependent manner by Aguado-Fraile, Elia, Hudson, Christine, Sleger, Taryn, Ronseaux, Sebastien, Narayanaswamy, Rohini, Choe, Sung, Wu, Bin, Kalev, Peter, Nicolay, Brandon

“…Abstract Mutations in the metabolic enzymes isocitrate dehydrogenase (IDH) 1 or 2 arise in a variety of malignancies and lead to the production of the…”
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Abstract 1810: The mutant IDH1 inhibitor ivosidenib promotes tumor cell differentiation and anti-tumor immunity in intrahepatic cholangiocarcinoma by Wu, Meng-Ju, Shi, Lei, Dubrot, Juan, Hudson, Christine, Merritt, Joshua, Adil, Ramzi, Wu, Qibiao, Ronseaux, Sebastien, Narayanaswamy, Rohini, Manguso, Robert, Nicolay, Brandon, Bardeesy, Nabeel

“…Abstract Intrahepatic cholangiocarcinoma (ICC) is a cancer of the liver bile ducts, which has been rising in incidence and carries a 5-year survival rate of…”
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Quantitation of 2-hydroxyglutarate in human plasma via LC–MS/MS using a surrogate analyte approach by Yin, Feng, Ling, Yonghua, Keller, Jennifer, Kraus, Dennis, Narayanaswamy, Rohini, Mangus, Heidi, Li, Fumin, Yang, Hua, Liu, Guowen

“…2-Hydroxyglutarate (2-HG) is a target engagement biomarker in patients after treatment with inhibitors of mutated isocitrate dehydrogenase (mIDH). Accurate…”
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Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase by McDonald, Gabrielle, Chubukov, Victor, Coco, John, Truskowski, Kevin, Narayanaswamy, Rohini, Choe, Sung, Steadman, Mya, Artin, Erin, Padyana, Anil K, Jin, Lei, Ronseaux, Sebastien, Locuson, Charles, Fan, Zi-Peng, Erdmann, Tabea, Mann, Alan, Hayes, Sebastian, Fletcher, Mark, Nellore, Kavitha, Rao, Siva Sanjeeva, Subramanya, Hosahalli, Reddy, K Satish, Panigrahi, Sunil K, Antony, Thomas, Gopinath, Sreevalsam, Sui, Zhihua, Nagaraja, Nelamangala, Dang, Lenny, Lenz, Georg, Hurov, Jonathan, Biller, Scott A, Murtie, Josh, Marks, Kevin M, Ulanet, Danielle B

“…Agents targeting metabolic pathways form the backbone of standard oncology treatments, though a better understanding of differential metabolic dependencies…”
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Combination of Enasidenib and Venetoclax Shows Superior Anti-Leukemic Activity Against IDH2 Mutated AML in Patient-Derived Xenograft Models by Cathelin, Severine, Sharon, David, Subedi, Amit, Cojocari, Dan, Phillips, Darren C., Leverson, Joel D., MacBeth, Kyle, Nicolay, Brandon, Narayanaswamy, Rohini, Ronseaux, Sebastien, Liu, Guowen, Chan, Steven M

“…Mutations in isocitrate dehydrogenase 2 (IDH2) promote AML pathogenesis through production of 2-hydroxyglutarate (2-HG). Enasidenib is an inhibitor of mutant…”
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