Search Results - "Narayanasamy, Angayarkanni"

Oxidized LDL, homocysteine, homocysteine thiolactone and advanced glycation end products act as pro-oxidant metabolites inducing cytokine release, macrophage infiltration and pro-angiogenic effect in ARPE-19 cells by AnandBabu, Kannadasan, Sen, Parveen, Angayarkanni, Narayanasamy

“…Age-related Macular Degeneration (AMD) is one of the major vision-threatening diseases of the eye. Oxidative stress is one of the key factors in the onset and…”
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Aqueous and alcoholic extracts of Triphala and their active compounds chebulagic acid and chebulinic acid prevented epithelial to mesenchymal transition in retinal pigment epithelial cells, by inhibiting SMAD-3 phosphorylation by Sivasankar, Shanmuganathan, Lavanya, Ramu, Brindha, Pemaiah, Angayarkanni, Narayanasamy

“…Epithelial to Mesenchymal Transition (EMT) of the retinal pigment epithelium is involved in the pathogenesis of proliferative vitreoretinopathy (PVR) that…”
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Low blood and vitreal BDNF, LXA4 and altered Th1/Th2 cytokine balance are potential risk factors for diabetic retinopathy by Kaviarasan, Kuppan, Jithu, Mohanlal, Arif Mulla, Mohammad, Sharma, Tarun, Sivasankar, Shanmuganathan, Das, Undurti Narasimha, Angayarkanni, Narayanasamy

“…Abstract Objective The study was conducted to observe the serum and vitreous levels of LXA4 , BDNF and Th1/Th2 cytokines in type 2 diabetes mellitus (DM) and…”
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Altered mucins and aquaporins indicate dry eye outcome in patients undergoing Vitreo-retinal surgery by Mani, Ramalingam, Shobha, P S, Thilagavathi, Saravanan, Prema, Padmanabhan, Viswanathan, Natarajan, Vineet, Ratra, Dhanashree, Ratra, Angayarkanni, Narayanasamy

“…Vitreo-retinal (VR) surgeries induce conjunctival changes. However, there are no study reports regarding prevalence and severity of dry eye after these…”
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Adiponectin-induced activation of ERK1/2 drives fibrosis in retinal pigment epithelial cells by Palanisamy, Karthikka, Karpagavalli, Muthuramalingam, Nareshkumar, Ragavachetty Nagaraj, Ramasubramanyan, Sharada, Angayarkanni, Narayanasamy, Raman, Rajiv, Chidambaram, Subbulakshmi

“…Adiponectin (APN), a vasoactive cytokine produced by adipocytes, has emerged as a critical player in retinal diseases. Renowned for its antioxidant,…”
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Paraoxonase enzyme protects retinal pigment epithelium from chlorpyrifos insult by Jasna, Jagan Mohan, Anandbabu, Kannadasan, Bharathi, Subramaniam Rajesh, Angayarkanni, Narayanasamy

“…Retinal pigment epithelium (RPE) provides nourishment and protection to the eye. RPE dysfunction due to oxidative stress and inflammation is one of the major…”
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Isolation of acid from eye drop bottles being used by patients presenting with presumed scleritis by Iyer, Geetha, Agarwal, Shweta, Srinivasan, Bhaskar, Narayanasamy, Angayarkanni

“…Purpose: The aim of the study was to report the occurrence of contamination/replacement of ophthalmic eye drops with liquids of acidic nature in patients…”
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Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome by Aluru, Saijyothi Venkata, Agarwal, Shweta, Srinivasan, Bhaskar, Iyer, Geetha Krishnan, Rajappa, Sivakumar M, Tatu, Utpal, Padmanabhan, Prema, Subramanian, Nirmala, Narayanasamy, Angayarkanni

“…Dry eye syndrome (DES) is a complex, multifactorial, immune-associated disorder of the tear and ocular surface. DES with a high prevalence world over needs…”
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Tear fluid small molecular antioxidants profiling shows lowered glutathione in keratoconus by Saijyothi, Aluru Venkata, Fowjana, Jenofar, Madhumathi, Subramanian, Rajeshwari, Mahadevan, Thennarasu, Maruthamuthu, Prema, Padmanaban, Angayarkanni, Narayanasamy

“…Keratoconus (KC) is a non-inflammatory disease of the cornea involving structural changes. Oxidative stress is reported to be parts of its pathology, yet the…”
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Three-dimensional spheroids of choroid-retinal vascular endothelial cells as an in-vitro model for diabetic retinopathy: Proof-of-concept investigation by Gore, Manish, Tiwari, Ankit, Jahagirdar, Devashree, Narayanasamy, Angayarkanni, Jain, Ratnesh, Dandekar, Prajakta

“…Diabetic retinopathy (DR) is a primary microvascular complication of diabetes mellitus and a vision-threatening condition. Vascular endothelial growth factor…”
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Probing the intermolecular interactions of PPAR[gamma]-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties by Muralikumar, Shalini, Vetrivel, Umashankar, Narayanasamy, Angayarkanni, N. Das, Undu

“…Background PPAR[gamma] is an isoform of peroxisome proliferator-activated receptor (PPAR) belonging to a super family of nuclear receptors. PPAR[gamma]…”
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Tear Fluid Protein Changes in Dry Eye Syndrome Associated with Rheumatoid Arthritis: A Proteomic Approach by Aluru, Saijyothi Venkata, PhD, Shweta, Agarwal, MBBS DO, Bhaskar, Srinivasan, MS, Geetha, Krishnan, MS, Sivakumar, Rajappa M., MD, Utpal, Tatu, PhD, Padmanabhan, Prema, MS, Angayarkanni, Narayanasamy, PhD

“…Abstract Purpose Sjögren syndrome (SS) secondary to rheumatoid arthritis (RA) affects lacrimal and salivary glands, and therefore dry eye syndrome (DES) is…”
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Case report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studies by Bharathi Devi, Subramaniam, Coral, Karunakaran, Gayathree, Karthikeyan, Bharathselvi, Muthuvel, Sivasankar, Shanmuganathan, Biswas, Jyotirmoy, Rishi, Pukhraj, Natarajan, Sundaram, Badrinath, Sengamedu, Angayarkanni, Narayanasamy

“…We were intrigued to analyze donor eyes of two individuals without retinopathy even after 40 years of type 2 diabetes mellitus. Targeted molecular factors…”
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Homocysteine induces oxidative stress in young adult central retinal vein occlusion by Bharathi Devi, Subramaniam Rajesh, Suganeswari, Ganesan, Sharma, Tarun, Thennarasu, Maruthamuthu, Angayarkanni, Narayanasamy

“…High levels of plasma homocysteine have been reported to be toxic to the vascular endothelium, thereby creating an environment of hypercoagulability and…”
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Chebulagic acid Chebulinic acid and Gallic acid, the active principles of Triphala, inhibit TNFα induced pro-angiogenic and pro-inflammatory activities in retinal capillary endothelial cells by inhibiting p38, ERK and NFkB phosphorylation by Shanmuganathan, Sivasankar, Angayarkanni, Narayanasamy

“…Tumor necrosis factor-α (TNFα) a pleiotropic cytokine induces pro-inflammatory and pro-angiogenic changes in conditions such as diabetic retinopathy (DR) and…”
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Agonistic effect of polyunsaturated fatty acids (PUFAs) and its metabolites on brain-derived neurotrophic factor (BDNF) through molecular docking simulation by Vetrivel, Umashankar, Ravichandran, Sathya Baarathi, Kuppan, Kaviarasan, Mohanlal, Jithu, Das, Undurti Narasimha, Narayanasamy, Angayarkanni

“…Brain-derived neurotrophic factor (BDNF) is a potent neurotrophic factor that is implicated in the regulation of food intake and body weight. Polyunsaturated…”
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Amino acids influence the glucose uptake through GLUT4 in CHO-K1 cells under high glucose conditions by Selvi, Radhakrishnan, Angayarkanni, Narayanasamy, Asma, Begum, Seethalakshmi, Thiagarajan, Vidhya, Srinivasan

“…According to studies earlier, amino acids have proven to be antidiabetic, antiglycating, and anticataractogenic. The present study was to explore whether amino…”
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Chebulagic acid and Chebulinic acid inhibit TGF-β1 induced fibrotic changes in the chorio-retinal endothelial cells by inhibiting ERK phosphorylation by Shanmuganathan, Sivasankar, Angayarkanni, Narayanasamy

“…Diabetic retinopathy (DR) is characterized by pro-inflammatory, pro-angiogenic and pro-fibrotic environment during the various stages of the disease…”
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Tear ascorbic acid levels and the total antioxidant status in contact lens wearers: a pilot study by Venkata, Sai Jyothi Aluru, Narayanasamy, Angayarkanni, Srinivasan, Vidhya, Iyer, Geetha Krishnan, Sivaramakrishnan, Ramakrishnan, Subramanian, Madhumathi, Mahadevan, Rajeshwari

“…The tear ascorbate owing to its high concentration, functions as an effective antioxidant against the oxidative damage of cornea. Contact lens wearers (CLW)…”
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Chebulagic acid Chebulinic acid and Gallic acid, the active principles of Triphala, inhibit TNFa induced pro-angiogenic and pro-inflammatory activities in retinal capillary endothelial cells by inhibiting p38, ERK and NFkB phosphorylation by Shanmuganathan, Sivasankar, Angayarkanni, Narayanasamy

“…Tumor necrosis factor-α (TNFα) a pleiotropic cytokine induces pro-inflammatory and pro-angiogenic changes in conditions such as diabetic retinopathy (DR) and…”
Get full text