Search Results - "Narayanan, Sanju"

Regulation of the Apelinergic System and Its Potential in Cardiovascular Disease: Peptides and Small Molecules as Tools for Discovery by Narayanan, Sanju, Harris, Danni L, Maitra, Rangan, Runyon, Scott P

“…Apelin peptides and the apelin receptor represent a relatively new therapeutic axis for the potential treatment of cardiovascular disease. Several reports…”
Get full text

Sigma receptors and cocaine abuse by Narayanan, Sanju, Mesangeau, Christophe, Poupaert, Jacques H, McCurdy, Christopher R

“…Sigma receptors have been well documented as a protein target for cocaine and have been shown to be involved in the toxic and stimulant actions of cocaine…”
Get more information

Regiospecific Synthesis of 2,3-Disubstituted- l-Histidines and Histamines by Narayanan, Sanju, Vangapandu, Suryanarayana, Jain, Rahul

“…Regiospecific synthesis of 2,3-disubstituted- l-histidines and 2,3-disubstituted histamines starting from l-histidine methyl ester and histamine is reported…”
Get full text

Identification of potent pyrazole based APELIN receptor (APJ) agonists by Narayanan, Sanju, Vasukuttan, Vineetha, Rajagopal, Sudarshan, Maitra, Rangan, Runyon, Scott P.

“…[Display omitted] The apelinergic system comprises the apelin receptor and its cognate apelin and elabela peptide ligands of various lengths. This system has…”
Get full text

Identification of Potent Pyrazole‐Based Biased Small Molecule APJ Receptor Agonists by Narayanan, Sanju, Vasukuttan, Vineetha, Rajagopal, Sudarshan, Maitra, Rangan, Runyon, Scott P

“…The apelinergic system comprises the APJ receptor and its cognate apelin and ELABELA peptides of various lengths. This system has become an increasingly…”
Get full text

Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin receptor by Narayanan, Sanju, Dai, Donghua, Vyas Devambatla, Ravi Kumar, Albert, Vincent, Bruneau-Latour, Nicolas, Vasukuttan, Vineetha, Ciblat, Stephane, Rehder, Kenneth, Runyon, Scott P., Maitra, Rangan

“…[Display omitted] The apelin receptor (APJ) is a target for cardiovascular indications. Previously, we had identified a novel pyrazole-based agonist 1…”
Get full text

Pyrazole Agonist of the Apelin Receptor Improves Symptoms of Metabolic Syndrome in Mice by Narayanan, Sanju, Wang, Shaobin, Vasukuttan, Vineetha, Vyas Devambatla, Ravi Kumar, Dai, Donghua, Jin, Chunyang, Snyder, Rodney, Laudermilk, Lucas, Runyon, Scott P, Maitra, Rangan

“…Apelin receptor agonism improves symptoms of metabolic syndrome. However, endogenous apelin peptides have short half-lives, making their utility as potential…”
Get full text

Discovery of a novel small molecule agonist scaffold for the APJ receptor by Narayanan, Sanju, Maitra, Rangan, Deschamps, Jeffery R., Bortoff, Katherine, Thomas, James B., Zhang, Yanyan, Warner, Keith, Vasukuttan, Vineetha, Decker, Ann, Runyon, Scott P.

“…[Display omitted] The apelinergic system includes a series of endogenous peptides apelin, ELABELA/TODDLER and their 7-transmembrane G-protein coupled apelin…”
Get full text

Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists by Katz, Jonathan L, Hiranita, Takato, Kopajtic, Theresa A, Rice, Kenner C, Mesangeau, Christophe, Narayanan, Sanju, Abdelazeem, Ahmed H, McCurdy, Christopher R

“…The identification of sigma receptor (σR) subtypes has been based on radioligand binding and, despite progress with σ1R cellular function, less is known about…”
Get more information

Regulation of the Apelinergic System and Its Potential in Cardiovascular Disease: Peptides and Small Molecules as Tools for Discovery: Miniperspective by Narayanan, Sanju, Harris, Danni L, Maitra, Rangan, Runyon, Scott P

“…Apelin peptides and the apelin receptor represent a relatively new therapeutic axis for the potential treatment of cardiovascular disease. Several reports…”
Get full text

Sigma Receptor Agonists: Receptor Binding and Effects on Mesolimbic Dopamine Neurotransmission Assessed by Microdialysis by Garcés-Ramírez, Linda, Green, Jennifer L, Hiranita, Takato, Kopajtic, Theresa A, Mereu, Maddalena, Thomas, Alexandra M, Mesangeau, Christophe, Narayanan, Sanju, McCurdy, Christopher R, Katz, Jonathan L, Tanda, Gianluigi

“…Background Subtypes of sigma (σ) receptors, σ1 and σ2 , can be pharmacologically distinguished, and each may be involved in substance-abuse disorders…”
Get full text

The dopamine uptake inhibitor, WIN 35,428, has sigma2 receptor agonist effects that contribute to its self‐administration (848.10) by Hiranita, Takato, Kopajtic, Theresa, Mesangeau, Christopher, Narayanan, Sanju, McCurdy, Christopher, Katz, Jonathan

“…Sigma receptors (σRs) are intracellular chaperone proteins implicated in several diseases, as well as psychiatric disorders and drug abuse. Several in vivo…”
Get full text

Early development of sigma-receptor ligands by Narayanan, Sanju, Bhat, Rohit, Mesangeau, Christophe, Poupaert, Jacques H, McCurdy, Christopher R

“…Sigma receptors (σ-1 and σ-2) are non-opioid proteins implicated in the pathophysiology of various neurological disorders and cancer. The σ-1 subtype is a…”
Get more information

Sigma receptor ligands attenuate methamphetamine‐induced hyperthermia but do not modulate IL‐1B mRNA expression in select brain regions by Seminerio, Michael John, Robson, Matthew J, Mesangeau, Christophe, Narayanan, Sanju, McCurdy, Christopher R, Matsumoto, Rae R

“…Abstract only Methamphetamine is one of the most widely abused drugs worldwide, with hyperthermia being a primary cause of death. Methamphetamine‐induced…”
Get full text

Synthesis and Pharmacological Evaluation of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a Cocaine Antagonist, in Rodents by Kaushal, Nidhi, Robson, Matthew J., Vinnakota, Harsha, Narayanan, Sanju, Avery, Bonnie A., McCurdy, Christopher R., Matsumoto, Rae R.

“…Cocaine interacts with monoamine transporters and sigma (σ) receptors, providing logical targets for medication development. In the present study, in vitro and…”
Get full text

Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2 by Thomas, James B, Giddings, Angela M, Olepu, Srinivas, Wiethe, Robert W, Harris, Danni L, Narayanan, Sanju, Warner, Keith R, Sarret, Philippe, Longpre, Jean-Michel, Runyon, Scott P, Gilmour, Brian P

“…Compounds acting via the GPCR neurotensin receptor type 2 (NTS2) display analgesic effects in relevant animal models. Using a pharmacophore model based on…”
Get full text

Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-le u cine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2 by Thomas, James B, Giddings, Angela M, Olepu, Srinivas, Wiethe, Robert W, Harris, Danni L, Narayanan, Sanju, Warner, Keith R, Sarret, Philippe, Longpre, Jean-Michel, Runyon, Scott P, Gilmour, Brian P

“…Compounds acting via the GPCR neurotensin receptor type 2 (NTS2) display analgesic effects in relevant animal models. Using a pharmacophore model based on…”
Get full text

Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series by Han, Sangdon, Narayanan, Sanju, Kim, Sun Hee, Calderon, Imelda, Zhu, Xiuwen, Kawasaki, Andrew, Yue, Dawei, Lehmann, Juerg, Wong, Amy, Buzard, Daniel J., Semple, Graeme, Carroll, Chris, Chu, Zhi-Liang, Al-Sharmma, Hussein, Shu, Hsin-Hui, Tung, Shiu-Feng, Unett, David J., Behan, Dominic P., Yoon, Woo Hyun, Morgan, Michael, Usmani, Khawja A., Chen, Chuan, Sadeque, Abu, Leonard, James N., Jones, Robert M.

“…[Display omitted] The design and optimization of a novel trans-1,4-dioxycyclohexane GPR119 agonist series is described. A lead compound 21 was found to be a…”
Get full text

Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists by Buzard, Daniel J., Kim, Sun Hee, Lehmann, Juerg, Han, Sangdon, Calderon, Imelda, Wong, Amy, Kawasaki, Andrew, Narayanan, Sanju, Bhat, Rohit, Gharbaoui, Tawfik, Lopez, Luis, Yue, Dawei, Whelan, Kevin, Al-Shamma, Hussien, Unett, David J., Shu, Hsin-Hui, Tung, Shiu-Feng, Chang, Steve, Chuang, Ching-Fen, Morgan, Michael, Sadeque, Abu, Chu, Zhi-Liang, Leonard, James N., Jones, Robert M.

“…A series of 5-fluoro-4,6-dialkoxypyrimidine GPR119 modulators were discovered and optimized for in vitro agonist activity. A lead molecule was identified that…”
Get full text

Conversion of a Highly Selective Sigma-1 Receptor–Ligand to Sigma-2 Receptor Preferring Ligands with Anticocaine Activity by Mésangeau, Christophe, Narayanan, Sanju, Green, Andrea M, Shaikh, Jamaluddin, Kaushal, Nidhi, Viard, Eddy, Xu, Yan-Tong, Fishback, James A, Poupaert, Jacques H, Matsumoto, Rae R, McCurdy, Christopher R

“…Cocaine’s toxicity can be mitigated by blocking its interaction with sigma-1 receptors. The involvement of sigma-2 receptors remains unclear. To investigate…”
Get full text