Search Results - "Narayana Subbiah Hari Narayana Moorthy"

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    Comparative Studies on Conventional and Microwave Assisted Synthesis of Benzimidazole and Their 2-Substituted Derivative with the Effect of Salt Form of Reactant by Dubey, Raghvendra, Narayana Subbiah Hari Narayana Moorthy

    “…Benzimidazole and their derivative were reported to have wide biological activities and were synthesized by using different solvents and ring closing agents…”
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    Journal Article
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    Synthesis, Biological Evaluation and In Silico Metabolic and Toxicity Prediction of Some Flavanone Derivatives by Narayana Subbiah Hari Narayana Moorthy, Singh, Rahul Jitendra, Singh, Hemendra Pratap, Gupta, Sayan Dutta

    “…Flavones chemically are anthoxanthins, occur either in the free state or as glycosides associated with tannins (flavanoids). Flavanoids (derivatives of…”
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    Journal Article
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    Molecular Dynamic Simulations-Based Conformational Analysis and Binding Study of CP-225917 on Farnesyl Transferase Enzyme by Narayana Subbiah Hari Narayana Moorthy, Chandrabose Karthikeyan, Elangovan Manivannan

    Published in Medical sciences forum (01-11-2022)
    “…CP-225917 was isolated from unidentified fungi and exhibits farnesyl transferase and squalene synthase inhibitory activity. In the present investigation,…”
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    Journal Article
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    In silico based structural analysis of some piperidine analogs as farnesyltransferase inhibitors by Moorthy, Narayana Subbiah Hari Narayana, Sousa, Sergio F, Ramos, Maria J, Fernandes, Pedro A

    “…In silico based QSAR and pharmacophore analyses of a series of piperidine derivatives were performed in order to investigate the structural features of the…”
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    Journal Article
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    Quantitative Structure–Activity Relationships of Selective Antagonists of Glucagon Receptor Using QuaSAR Descriptors by Kumar, Palanivelu Manoj, Karthikeyan, Chandrabose, Narayana Subbiah Hari Narayana Moorthy, Trivedi, Piyush

    “…In the present paper, quantitative structure activity relationship (QSAR) approach was applied to understand the affinity and selectivity of a novel series of…”
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    Design, Synthesis and Biological Evaluation of Novel 1H-benzo[d]imidazole Derivatives as Fatty Acid Synthase (FASN) Inhibitors for Cancer Treatment by Shailendra Singh, Subarno Paul, Chandrabose Karthikeyan, Natércia F. Brás, Chanakya Nath Kundu, Narayana Subbiah Hari Narayana Moorthy

    Published in Medical sciences forum (01-11-2022)
    “…FASN is a metabolic oncoprotein that is overexpressed in multiple cancers and regulates the fatty acid requirements of proliferating cells. Thus, FASN has been…”
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    Classification analysis of fatty acid synthase inhibitors using multialgorithms on topological descriptors and structural fingerprints by Singh, Shailendra, Karthikeyan, Chandrabose, Moorthy, Narayana Subbiah Hari Narayana

    Published in Chemical biology & drug design (01-02-2023)
    “…Fatty acid synthase (FASN) is one of the enzymes required for fatty acid biosynthesis and is expressed as low or absent in most normal cells/tissues. However,…”
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