Search Results - "Narayana, Sthanam V L"

Pilus biogenesis of Gram‐positive bacteria: Roles of sortases and implications for assembly by Khare, Baldeep, V. L. Narayana, Sthanam

“…Successful adherence, colonization, and survival of Gram‐positive bacteria require surface proteins, and multiprotein assemblies called pili. These surface…”
Get full text

Two autonomous structural modules in the fimbrial shaft adhesin FimA mediate Actinomyces interactions with streptococci and host cells during oral biofilm development by Mishra, Arunima, Devarajan, Bharanidharan, Reardon, Melissa E., Dwivedi, Prabhat, Krishnan, Vengadesan, Cisar, John O., Das, Asis, Narayana, Sthanam V. L., Ton‐That, Hung

“…Summary By combining X‐ray crystallography and modelling, we describe here the atomic structure of distinct adhesive moieties of FimA, the shaft fimbrillin of…”
Get full text

Structure of Streptococcus agalactiae tip pilin GBS104: a model for GBS pili assembly and host interactions by Krishnan, Vengadesan, Dwivedi, Prabhat, Kim, Brandon J., Samal, Alexandra, Macon, Kevin, Ma, Xin, Mishra, Arunima, Doran, Kelly S., Ton-That, Hung, Narayana, Sthanam V. L.

“…The crystal structure of a 75 kDa central fragment of GBS104, a tip pilin from the 2063V/R strain of Streptococcus agalactiae (group B streptococcus; GBS), is…”
Get full text

Secreted Proteases Control Autolysin-mediated Biofilm Growth of Staphylococcus aureus by Chen, Chen, Krishnan, Vengadesan, Macon, Kevin, Manne, Kartik, Narayana, Sthanam V.L., Schneewind, Olaf

“…Staphylococcus epidermidis, a commensal of humans, secretes Esp protease to prevent Staphylococcus aureus biofilm formation and colonization. Blocking S…”
Get full text

Structural biology of gram‐positive bacterial adhesins by Vengadesan, Krishnan, Narayana, Sthanam V. L.

“…The structural biology of Gram‐positive cell surface adhesins is an emerging field of research, whereas Gram‐negative pilus assembly and anchoring have been…”
Get full text

The Enterococcus faecalis MSCRAMM ACE Binds Its Ligand by the Collagen Hug Model by Liu, Qing, Ponnuraj, Karthe, Xu, Yi, Ganesh, Vannakambadi K., Sillanpää, Jouko, Murray, Barbara E., Narayana, Sthanam V.L., Höök, Magnus

“…We have determined the crystal structure of the ligand binding segment of the Enterococcus faecalis collagen binding MSCRAMM ACE (microbial surface components…”
Get full text

Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase A by Chenna, Bala Chandra, Shinkre, Bidhan A., King, Jason R., Lucius, Aaron L., Narayana, Sthanam V.L., Velu, Sadanandan E.

“…A novel class of inhibitors of Staphylococcus aureus Sortase A is discovered by in-silico virtual screening and structure activity relationship studies…”
Get full text

Crystal Structures of Staphylococcus aureus Sortase A and Its Substrate Complex by Zong, Yinong, Bice, Todd W, Ton-That, Hung, Schneewind, Olaf, Narayana, Sthanam V L

“…The cell wall envelope of staphylococci and other Gram-positive pathogens is coated with surface proteins that interact with human host tissues. Surface…”
Get full text

The Crystal Structure Analysis of Group B Streptococcus Sortase C1: A Model for the “Lid” Movement upon Substrate Binding by Khare, Baldeep, Fu, Zheng-Qing, Huang, I-Hsiu, Ton-That, Hung, Narayana, Sthanam V.L.

“…A unique feature of the class-C-type sortases, enzymes essential for Gram-positive pilus biogenesis, is the presence of a flexible “lid” anchored in the active…”
Get full text

An IgG-like Domain in the Minor Pilin GBS52 of Streptococcus agalactiae Mediates Lung Epithelial Cell Adhesion by Krishnan, Vengadesan, Gaspar, Andrew H., Ye, Naiqing, Mandlik, Anjali, Ton-That, Hung, Narayana, Sthanam V.L.

“…Streptococcus agalactiae is the leading cause of neonatal pneumonia, sepsis, and meningitis. The pathogen assembles heterotrimeric pilus structures on its…”
Get full text

Purification, crystallization and preliminary X-ray diffraction analysis of the Staphylococcus epidermidis extracellular serine protease Esp by Vengadesan, Krishnan, Macon, Kevin, Sugumoto, Shinya, Mizunoe, Yoshimitsu, Iwase, Tadayuki, Narayana, Sthanam V. L.

“…Esp, an extracellular serine protease from Staphylococcus epidermidis, has been shown to inhibit S. aureus biofilm formation and nasal colonization. The…”
Get full text

Evidence for the “Dock, Lock, and Latch” Ligand Binding Mechanism of the Staphylococcal Microbial Surface Component Recognizing Adhesive Matrix Molecules (MSCRAMM) SdrG by Bowden, M. Gabriela, Heuck, Alejandro P., Ponnuraj, Karthe, Kolosova, Elena, Choe, Damon, Gurusiddappa, Sivashankarappa, Narayana, Sthanam V.L., Johnson, Arthur E., Höök, Magnus

“…Staphylococcus epidermidis is an opportunistic pathogen and a major cause of foreign body infections. The S. epidermidis fibrinogen (Fg)-binding adhesin SdrG…”
Get full text

The structure of complement C3b provides insights into complement activation and regulation by Volanakis, John E, Narayana, Sthanam. V. L, Krishna Murthy, H. M, Kotwal, Girish J, Abdul Ajees, A, Gunasekaran, K

“…The human complement system is an important component of innate immunity. Complement-derived products mediate functions contributing to pathogen killing and…”
Get full text

A Model for Group B Streptococcus Pilus Type 1: The Structure of a 35-kDa C-Terminal Fragment of the Major Pilin GBS80 by Vengadesan, Krishnan, Ma, Xin, Dwivedi, Prabhat, Ton-That, Hung, Narayana, Sthanam V.L.

“…The Gram-positive pathogen Streptococcus agalactiae, known as group B Streptococcus (GBS), is the leading cause of bacterial septicemia, pneumonia, and…”
Get full text

Structural insights into the role of the N‐terminus in the activation and function of extracellular serine protease from Staphylococcus epidermidis by Manne, Kartik, Narayana, Sthanam V. L.

“…Extracellular serine protease (Esp) from Staphylococcus epidermidis is a glutamyl endopeptidase that inhibits the growth and formation of S. aureus biofilms…”
Get full text

Novel structure of the N‐terminal helical domain of BibA, a group B streptococcus immunogenic bacterial adhesin by Manne, Kartik, Chattopadhyay, Debasish, Agarwal, Vaibhav, Blom, Anna M., Khare, Baldeep, Chakravarthy, Srinivas, Chang, Chungyu, Ton-That, Hung, Narayana, Sthanam V. L.

“…BibA, a group B streptococcus (GBS) surface protein, has been shown to protect the pathogen from phagocytic killing by sequestering a complement inhibitor:…”
Get full text

Deciphering complement mechanisms: The contributions of structural biology by Arlaud, Gérard J., Barlow, Paul N., Gaboriaud, Christine, Gros, Piet, Narayana, Sthanam V.L.

“…Since the resolution of the first three-dimensional structure of a complement component in 1980, considerable efforts have been put into the investigation of…”
Get full text

Crystal structure of the N‐terminal domain of the fibronectin‐binding protein PavA from Streptococcus pneumoniae by Manne, Kartik, Narayana, Sthanam V. L., Chattopadhyay, Debasish

“…The Gram‐positive bacterium Streptococcus pneumoniae, a major human pathogen, is a regular colonizer of the upper and lower respiratory tracts. Pneumococcal…”
Get full text

Structural and Biochemical Characterization of Staphylococcus aureus Clumping Factor B/Ligand Interactions by Ganesh, Vannakambadi K., Barbu, E. Magda, Deivanayagam, Champion C.S., Le, Binh, Anderson, Analiesa S., Matsuka, Yury V., Lin, Shuo L., Foster, Timothy J., Narayana, Sthanam V.L., Höök, Magnus

“…Clumping factor B (ClfB) from Staphylococcus aureus is a bifunctional protein that binds to human cytokeratin 10 (K10) and fibrinogen (Fg). ClfB has been…”
Get full text

Purification, crystallization and halide phasing of a Streptococcus agalactiae backbone pilin GBS80 fragment by Vengadesan, Krishnan, Ma, Xin, Dwivedi, Prabhat, Ton-That, Hung, Narayana, Sthanam V. L.

“…The Gram‐positive pathogen Streptococcus agalactiae or group B streptococcus (GBS) is the leading cause of bacterial septicemia, pneumonia and meningitis among…”
Get full text