Search Results - "Narayan, Nicole"
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A Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug Testing
Published in Cancers (18-09-2020)“…Hepatoblastoma is the most common childhood liver cancer. Although survival has improved significantly over the past few decades, there remains a group of…”
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Piphillin predicts metagenomic composition and dynamics from DADA2-corrected 16S rDNA sequences
Published in BMC genomics (17-01-2020)“…Shotgun metagenomic sequencing reveals the potential in microbial communities. However, lower-cost 16S ribosomal RNA (rRNA) gene sequencing provides taxonomic,…”
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Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening
Published in Cancer discovery (01-10-2021)“…To repurpose therapeutics for fibrolamellar carcinoma (FLC), we developed and validated patient-derived xenografts (PDX) from surgical resections. Most agents…”
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Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems
Published in Science translational medicine (03-09-2014)“…Diet has a strong influence on the intestinal microbiota in both humans and animal models. It is well established that microbial colonization is required for…”
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The Effect of Early Limited Formula on Breastfeeding, Readmission, and Intestinal Microbiota: A Randomized Clinical Trial
Published in The Journal of pediatrics (01-05-2018)“…To determine whether using 10 mL formula after each breastfeeding before copious maternal milk production affects breastfeeding duration, readmission, and…”
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Human liver organoids for disease modeling of fibrolamellar carcinoma
Published in Stem cell reports (09-08-2022)“…Fibrolamellar carcinoma (FLC) is a rare, often lethal, liver cancer affecting adolescents and young adults, for which there are no approved therapeutics. The…”
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Intraoperative Radiation Therapy for Relapsed or Refractory High-Risk Neuroblastoma: A 27-Year Experience
Published in Practical Radiation Oncology (01-05-2024)“…To evaluate outcomes after intraoperative radiation therapy (IORT) in high-risk neuroblastoma (NB), including local control, overall survival, and toxicity…”
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Correction to: Piphillin predicts metagenomic composition and dynamics from DADA2- corrected 16S rDNA sequences
Published in BMC genomics (31-01-2020)“…Following the publication of this article [1], the authors reported errors in Figs. 1, 2 and 5. Due to a typesetting error the asterisks denoting significance…”
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Cytomegalovirus infection disrupts the influence of short-chain fatty acid producers on Treg/Th17 balance
Published in Microbiome (10-10-2022)“…Both the gut microbiota and chronic viral infections have profound effects on host immunity, but interactions between these influences have been only…”
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Transient Effect of Infant Formula Supplementation on the Intestinal Microbiota
Published in Nutrients (01-03-2021)“…Breastfeeding is the gold standard for feeding infants because of its long-term benefits to health and development, but most infants in the United States are…”
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Strain level and comprehensive microbiome analysis in inflammatory bowel disease via multi-technology meta-analysis identifies key bacterial influencers of disease
Published in Frontiers in microbiology (14-10-2022)“…ObjectiveInflammatory bowel disease (IBD) is a heterogenous disease in which the microbiome has been shown to play an important role. However, the precise…”
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StrainSelect: A novel microbiome reference database that disambiguates all bacterial strains, genome assemblies and extant cultures worldwide
Published in Heliyon (01-02-2023)“…Motivation: Microbial metagenomic profiling software and databases are advancing rapidly for development of novel disease biomarkers and therapeutics yet three…”
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Persistent effects of early infant diet and associated microbiota on the juvenile immune system
Published in Gut microbes (04-07-2015)“…Early infant diet has significant impacts on the gut microbiota and developing immune system. We previously showed that breast-fed and formula-fed rhesus…”
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Novel multi-technology meta-analysis identifies gut microbiome strains associated with clinical fibrosis in NAFLD patients
Published in Journal of hepatology (01-07-2022)Get full text
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Metabolic reprogramming of the intestinal microbiome with functional bile acid changes underlie the development of NAFLD
Published in Hepatology (Baltimore, Md.) (01-12-2022)“…Background and Aims Bile acids are hepatic metabolites and have many properties considered to be relevant to the pathophysiology of NAFLD. Circulating levels…”
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Tu1516: IDENTIFICATION AND DEVELOPMENT OF A 1ST IN CLASS NATURALLYDERIVED PROTEIN THAT DRIVES MUCOSAL HEALING AND IS ORALLY DELIVERED BY AN ENGINEERED CELLULAR THERAPY TARGETING THE GASTRO-INTESTINAL TRACT
Published in Gastroenterology (New York, N.Y. 1943) (01-05-2022)Get full text
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SELECTION OF MICROBIOME-DERIVED PEPTIDES THROUGH MULTI-TECHNOLOGY META-ANALYSIS, BINDING, AND FUNCTIONAL ASSAYS, IDENTIFIES PEPTIDES WITH THERAPEUTIC POTENTIAL THAT MODULATE IMMUNE RESPONSES AND DISEASE
Published in Inflammatory bowel diseases (22-01-2022)“…Microbiome-driven drug discovery holds great promise for therapeutic development. However, identification of disease-associated microbiome-host interactions…”
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Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate
Published in PLoS genetics (01-03-2015)“…Cleft lip with or without cleft palate (CL/P) is the most commonly occurring craniofacial birth defect. We provide insight into the genetic etiology of this…”
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