Search Results - "Naraoka, Hitoshi"

Usefulness of a humanized tricellular static transwell blood–brain barrier model as a microphysiological system for drug development applications. - A case study based on the benchmark evaluations of blood-brain barrier microphysiological system by Nakayama-Kitamura, Kimiko, Shigemoto-Mogami, Yukari, Toyoda, Hiroko, Mihara, Ikue, Moriguchi, Hiroyuki, Naraoka, Hitoshi, Furihata, Tomomi, Ishida, Seiichi, Sato, Kaoru

“…Microphysiological system (MPS), a new technology for in vitro testing platforms, have been acknowledged as a strong tool for drug development. In the central…”
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Metabolic Profiling to Identify Potential Serum Biomarkers for Gastric Ulceration Induced by Nonsteroid Anti-Inflammatory Drugs by Takeuchi, Kenichiro, Ohishi, Maki, Ota, Sana, Suzumura, Kenichi, Naraoka, Hitoshi, Ohata, Takeji, Seki, Jiro, Miyamae, Youichi, Honma, Masashi, Soga, Tomoyoshi

“…Nonsteroid anti-inflammatory drugs (NSAIDs) are among the most frequently prescribed drugs currently available. The most frequently reported serious side…”
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Cardiotoxicity evaluation using three-dimensional cardiac tissues consisting of human iPS cell-derived cardiomyocytes and fibroblasts by cell coating technique by Tadano, Kiyoshi, Kazusa, Katsuyuki, Takamatsu, Kazuhiko, Naraoka, Hitoshi, Takeda, Maki, Akashi, Mitsuru, Miyagawa, Shigeru, Sawa, Yoshiki

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Progression process and safety assessment adaptation of endometrial lesions in ENU-induced 2-stage uterine carcinogenicity in a Tg-rasH2 mouse model by Kuroda, Hiroyuki, Kinomoto, Toshiko, Ogawa, Shuji, Kawabe, Mayumi, Suguro, Mayuko, Naraoka, Hitoshi, Takamatsu, Kazuhiko, Oishi, Yuji

“…Although acotiamide hydrochloride hydrate (acotiamide-HH) has not been reported to have genotoxic findings in any of the genotoxicity studies or…”
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Metabolomic analysis of the effects of omeprazole and famotidine on aspirin-induced gastric injury by Takeuchi, Kenichiro, Ohishi, Maki, Endo, Keiko, Suzumura, Kenichi, Naraoka, Hitoshi, Ohata, Takeji, Seki, Jiro, Miyamae, Yoichi, Honma, Masashi, Soga, Tomoyoshi

“…Gastric mucosal ulceration and gastric hemorrhage are frequently associated with treatment by non-steroid anti-inflammatory drugs (NSAIDs); however, no…”
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Pharma challenges to adoption of microphysiological system in drug research and development, especially safety assessment by Naraoka, Hitoshi

“…In the environment surrounding the pharma industries (1) declining productivity in research and development in pharma industries, (2) spreading of 3Rs in…”
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Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin by Takeuchi, Kenichiro, Ohishi, Maki, Endo, Keiko, Suzumura, Kenichi, Naraoka, Hitoshi, Ohata, Takeji, Seki, Jiro, Miyamae, Yoichi, Honma, Masashi, Soga, Tomoyoshi

“…Gastrointestinal symptoms are a common manifestation of adverse drug effects. Non-steroid anti-inflammatory drugs (NSAIDs) are widely prescribed drugs that…”
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Evaluation of H-FABP as a marker of ongoing myocardial damage using hGH transgenic mice by Naraoka, Hitoshi, Ito, Kyoko, Suzuki, Michie, Naito, Kunihiko, Tojo, Hideaki

“…There are few heart-specific and highly sensitive biomarkers of cardiac disorders in experimental animals. To evaluate ongoing myocardial damage in…”
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Analysis of Gender Difference of Cardiac Risk Biomarkers Using hGH-Transgenic Mice by NARAOKA, Hitoshi, ITO, Kyoko, SUZUKI, Michie, NAITO, Kunihiko, TOJO, Hideaki

“…We investigated gender difference in the effects of chronic exposure to human growth hormone (hGH) on cardiac risk biomarkers using transgenic mice with…”
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Opportunities for Microphysiological Systems from the View of Japanese Industries by Naraoka, Hitoshi, Iguchi, Takuma, Harada, Kosuke, Usui, Toru, Suwa, Yoshiaki, Ando, Masamitsu, Sakura, Takeshi, Ohkubo, Tomoki

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Role of biomarkers in toxicity treatment "metabonomics" as a new biomarker discovery method by Naraoka, Hitoshi, Suzumura, Ken-ichi, Takeuchi, Ken-ichiro, Sasayama, Takeshi

“…For the treatment of clinical toxicity, investigations to determine the offending substance and rapid treatment are required. Particularly in the case of drug…”
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Investigation of Mechanisms for MK-801-Induced Neurotoxicity Utilizing Metabolomic Approach by Kuroda, Kanae, Suzumura, Kenichi, Shirakawa, Takafumi, Hiraishi, Tomoko, Nakahara, Yutaka, Fushiki, Hiroshi, Honda, Sokichi, Naraoka, Hitoshi, Miyoshi, Sosuke, Aoki, Yoshinobu

“…Single treatment of rats with the noncompetitive N-methyl-D-aspartate receptor antagonist MK-801 induces neuronal cell degeneration and death in the…”
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Consideration for the validation of clinical laboratory methods in nonclinical fields by Minomo, Hirofumi, Inoue, Yoshimi, Iwachido, Takako, Oota, Hiromi, Otabe, Koji, Kubono, Katsuo, Kondo, Satoshi, Sasaki, Daisuke, Suzuki, Yusuke, Nakamura, Yuta, Naraoka, Hitoshi, Higashiyama, Masumi, Fujisawa, Nozomi, Honda, Kumi, Matsumoto, Tadao, Yasui, Hideki, Saito, Yoshiro, Toyota, Naoto

“…In new drug development, cells or animals are treated with the selected candidate compound to confirm its efficacy and safety in nonclinical studies. Clinical…”
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[18F]FDG-PET as an imaging biomarker to NMDA receptor antagonist-induced neurotoxicity by Shirakawa, Takafumi, Mitsuoka, Keisuke, Kuroda, Kanae, Miyoshi, Sosuke, Shiraki, Katsuhisa, Naraoka, Hitoshi, Noda, Akihiro, Fujikawa, Akihiko, Fujiwara, Michio

“…Positron emission tomography (PET) is an effective tool for noninvasive examination of the body and provides a range of functional information. PET imaging…”
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Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin by Kenichiro Takeuchi, Maki Ohishi, Keiko Endo, Kenichi Suzumura, Hitoshi Naraoka, Takeji Ohata, Jiro Seki, Yoichi Miyamae, Masashi Honma, Tomoyoshi Soga

“…Gastrointestinal symptoms are a common manifestation of adverse drug effects. Non-steroid anti-inflammatory drugs (NSAIDs) are widely prescribed drugs that…”
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