In vitro bactericidal activity of cefepime and cefpirome against clinical isolates at Karachi

Antibiotics not only support to alleviate the infections but also facilitate to avert the multiplication of microbes. Due to the irrational use of antibiotics, the resistance of antibiotics has been augmented which results may increase in morbidity and mortality with the span of time. World renowned...

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Published in:	Pakistan journal of pharmaceutical sciences Vol. 28; no. 3; pp. 841 - 847
Main Authors:	Arsalan, Adeel, Naqvi, Syed Baqar Shayam, Ali, Syed Abid, Ahmed, Sadia, Shakeel, Osama
Format:	Journal Article
Language:	English
Published:	Pakistan Pakistan Journal of Pharmaceutical Sciences 01-05-2015
Subjects:	Anti-Bacterial Agents - pharmacology Bacteremia - microbiology Cefepime Cefpirome Cephalosporins Cephalosporins - pharmacology Communicable diseases Dosage and administration Drug Resistance, Bacterial Drug therapy Escherichia coli - drug effects Escherichia coli - isolation & purification Escherichia coli Infections - microbiology Humans In Vitro Techniques Intraabdominal Infections Klebsiella Infections - microbiology Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - isolation & purification Microbial drug resistance Microbial Sensitivity Tests Pakistan Pharmacological research Proteus - drug effects Proteus - isolation & purification Proteus Infections - microbiology Respiratory Tract Infections - microbiology Skin Diseases, Bacterial - microbiology Soft Tissue Infections - microbiology Staphylococcal Infections - microbiology Staphylococcus aureus - drug effects Staphylococcus aureus - isolation & purification Urinary Tract Infections - microbiology Pakistan
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Summary:	Antibiotics not only support to alleviate the infections but also facilitate to avert the multiplication of microbes. Due to the irrational use of antibiotics, the resistance of antibiotics has been augmented which results may increase in morbidity and mortality with the span of time. World renowned regulatory bodies like Food and Drug Administration (FDA), Center of Disease Control and Prevention (CDC), and World Health Organization (WHO) vigorously advocate the surveillance of the resistance of antibiotics. During the present study by Kirby-Bauer disk diffusion method 141 clinical isolates of Staphylococcus aureus (n=47, 33.34%), Escherichia coli (n=54, 38.3%), Proteus species (n=26, 18.4%), and Klebsiella pneumoniae (n=14, 9.92%) are evaluated against cefepime and cefpirome which comes of fourth generation cephalosporin. It has been found that cefpirome has better bactericidal activity than cefepime against E. coli and K. pneumoniae while cefepime has been possessed better antibacterial activity against S. aureus and Proteus species which were isolated from respiratory tract infections, blood stream infection, intra-abdominal and urinary tract infections, and skin and soft tissue infections. K. pneumoniae, E. coli, Proteus species, and S. aureus were 34.8%, 26.3%, 11.3%, and 37.7% resistance against cefepime respectively. S. aureus, E. coli, K. pneumoniae, Proteus species has shown 41.4%, 21.7%, 17.6%, and 8.9% resistance against cefpirome correspondingly.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1011-601X