Search Results - "Naqvi, Ibtehaj"

SARS-CoV-2 viremia but not respiratory viral load is associated with respiratory complications in patients with severe COVID-19 by Chen, Lingye, Olson, Lyra B, Naqvi, Ibtehaj A, Sullenger, Bruce A, Que, Loretta G, Denny, Thomas N, Kraft, Bryan D

“…Severe COVID-19 carries a high morbidity and mortality. Previous studies have shown an association between COVID-19 severity and SARS-CoV-2 viral load (VL). We…”
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Suppression of Fibrinolysis and Hypercoagulability, Severity of Hypoxemia, and Mortality in COVID-19 Patients: A Retrospective Cohort Study by Corey, Kristin M., Olson, Lyra B., Naqvi, Ibtehaj A., Morrison, Sarah A., Davis, Connor, Nimjee, Shahid M., Que, Loretta G., Bachelder, Robin E., Kraft, Bryan D., Chen, Lingye, Nair, Smita K., Levy, Jerrold H., Sullenger, Bruce A.

“…COVID-19 causes hypercoagulability, but the association between coagulopathy and hypoxemia in critically ill patients has not been thoroughly explored. This…”
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Breast cancer-derived DAMPs enhance cell invasion and metastasis, while nucleic acid scavengers mitigate these effects by Eteshola, Elias O.U., Landa, Karenia, Rempel, Rachel E., Naqvi, Ibtehaj A., Hwang, E. Shelley, Nair, Smita K., Sullenger, Bruce A.

“…Breast cancer (BC) is the most common malignancy in women. Particular subtypes with aggressive behavior are major contributors to poor outcomes…”
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Abstract 4554: Toll-like receptor expression and ligation promotes in vitro invasion in pancreatic cancer by Naqvi, Ibtehaj A., McDade, Jessica, Lee, Jaewoo, White, Rebekah

“…Abstract Introduction: Pancreatic cancer (PC) has the worst prognosis of all the major cancers. The role of inflammation in tumor progression and metastasis,…”
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A Gain-of-Function Polymorphism Controlling Complex Traits and Fitness in Nature by Prasad, Kasavajhala V. S. K., Song, Bao-Hua, Olson-Manning, Carrie, Anderson, Jill T., Lee, Cheng-Ruei, Schranz, M. Eric, Windsor, Aaron J., Clauss, Maria J., Manzaneda, Antonio J., Naqvi, Ibtehaj, Reichelt, Michael, Gershenzon, Jonathan, Rupasinghe, Sanjeewa G., Schuler, Mary A., Mitchell-Olds, Thomas

“…Identification of the causal genes that control complex trait variation remains challenging, limiting our appreciation of the evolutionary processes that…”
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Combining Heparin and a FX/Xa Aptamer to Reduce Thrombin Generation in Cardiopulmonary Bypass and COVID-19 by Chabata, Charlene V, Frederiksen, James W, Olson, Lyra B, Naqvi, Ibtehaj A, Hall, Sharon E, Gunaratne, Ruwan, Kraft, Bryan D, Que, Loretta G, Chen, Lingye, Sullenger, Bruce A

“…Known limitations of unfractionated heparin (UFH) have encouraged the evaluation of anticoagulant aptamers as alternatives to UFH in highly procoagulant…”
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Functional reprogramming of peripheral blood monocytes by soluble mediators in patients with pancreatic cancer and intraductal papillary mucinous neoplasms by Eckhoff, Austin M, Brown, Michael C, Landa, Karenia, Naqvi, Ibtehaj, Holl, Eda K, Boczkowski, David, Fletcher, Ashley, Rhodin, Kristen E, Giang, Minh Huy, Sullenger, Bruce, Beasley, Georgia M, Allen, Peter J, Nair, Smita K

“…Monocytes and monocyte-derived tumor infiltrating cells have been implicated in the immunosuppression and immune evasion associated with pancreatic…”
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Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test by Heggestad, Jacob T, Kinnamon, David S, Olson, Lyra B, Liu, Jason, Kelly, Garrett, Wall, Simone A, Oshabaheebwa, Solomon, Quinn, Zachary, Fontes, Cassio M, Joh, Daniel Y, Hucknall, Angus M, Pieper, Carl, Anderson, Jack G, Naqvi, Ibtehaj A, Chen, Lingye, Que, Loretta G, Oguin, 3rd, Thomas, Nair, Smita K, Sullenger, Bruce A, Woods, Christopher W, Burke, Thomas W, Sempowski, Gregory D, Kraft, Bryan D, Chilkoti, Ashutosh

“…Highly sensitive, specific, and point-of-care (POC) serological assays are an essential tool to manage coronavirus disease 2019 (COVID-19). Here, we report on…”
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Impact of Surveillance After Lobectomy for Lung Cancer on Disease Detection and Survival by Mayne, Nicholas R., Mallipeddi, Mohan K., Darling, Alice J., Jeffrey Yang, Chi-Fu, Eltaraboulsi, Walid R., Shoffner, Adam R., Naqvi, Ibtehaj A., D’Amico, Thomas A., Berry, Mark F.

“…Existing guidelines for surveillance after non–small-cell lung cancer (NSCLC) treatment are inconsistent and have relatively sparse supporting literature. This…”
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Age and Comorbidities Predict COVID-19 Outcome, Regardless of Innate Immune Response Severity: A Single Institutional Cohort Study by Mohan, Aditya A, Olson, Lyra B, Naqvi, Ibtehaj A, Morrison, Sarah A, Kraft, Bryan D, Chen, Lingye, Que, Loretta G, Ma, Qing, Barkauskas, Christina E, Kirk, Allan, Nair, Smita K, Sullenger, Bruce A, Kasotakis, George

“…The COVID-19 pandemic has claimed over eight hundred thousand lives in the United States alone, with older individuals and those with comorbidities being at…”
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Key Pathogenic Factors in Coronavirus Disease 2019–Associated Coagulopathy and Acute Lung Injury Highlighted in a Patient With Copresentation of Acute Myelocytic Leukemia: A Case Report by Olson, Lyra B., Naqvi, Ibtehaj A., Turner, Daniel J., Morrison, Sarah A., Kraft, Bryan D., Chen, Lingye, Sullenger, Bruce A., Nair, Smita K., Que, Loretta G., Levy, Jerrold H.

“…The role of concurrent illness in coronavirus disease 2019 (COVID-19) is unknown. Patients with leukemia may display altered thromboinflammatory responses. We…”
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DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonists by Naqvi, Ibtehaj, Giroux, Nicholas, Olson, Lyra, Morrison, Sarah Ahn, Llanga, Telmo, Akinade, Tolu O., Zhu, Yuefei, Zhong, Yiling, Bose, Shree, Arvai, Stephanie, Abramson, Karen, Chen, Lingye, Que, Loretta, Kraft, Bryan, Shen, Xiling, Lee, Jaewoo, Leong, Kam W., Nair, Smita K., Sullenger, Bruce

“…Millions of COVID-19 patients have succumbed to respiratory and systemic inflammation. Hyperstimulation of toll-like receptor (TLR) signaling is a key driver…”
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135: AGE AND COMORBIDITIES PREDICT COVID-19 OUTCOME REGARDLESS OF SEVERITY OF INNATE IMMUNE RESPONSE by Mohan, Aditya, Olson, Lyra, Naqvi, Ibtehaj, Morrison, Sarah, Kraft, Bryan, Chen, Lingye, Nair, Smita, Sullenger, Bruce, Kasotakis, George

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Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples by Soule, Erin E, Yu, Haixiang, Olson, Lyra, Naqvi, Ibtehaj, Kumar, Shekhar, Krishnaswamy, Sriram, Sullenger, Bruce A

“…Coagulation cofactors profoundly regulate hemostasis and are appealing targets for anticoagulants. However, targeting such proteins has been challenging…”
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Abstract 4515: Utilizing nucleic-acid scavengers (NASs) to inhibit proinflammatory and proinvasive signaling in triple-negative breast cancer by Eteshola, Elias O., Naqvi, Ibtehaj A., Gunaratne, Ruwan, Moreno, Angelo, Nair, Smita K., Sullenger, Bruce A.

“…Abstract Breast cancers (BC) remain the most lethal malignancies amongst women worldwide and the second leading cause of cancer-related mortalities in the US…”
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Abstract P102: Elevated Von Willebrand Factor in Patients Presenting With Large-Vessel Occlusion Stroke as First Symptom of COVID-19 Mirrors Levels in Patients With COVID-19 Requiring ICU-Level Care by Olson, Lyra B, Naqvi, Ibtehaj A, CHEN, LINGYE, Que, Loretta G, KRAFT, BRYAN D, Nair, Smita K, Nimjee, Shahid M, Sullenger, Bruce A

“…IntroductionCOVID-19 is a coagulopathic disease marked by elevated d-dimers, fibrinogen, and von Willebrand factor (vWF) levels accompanying arterial and…”
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Exposure and Outcome in practice: a retrospective cohort study between fibrinolytic suppression and hypercoagulability, the severity of hypoxemia, and mortality in COVID-19 patients by Corey, Kristin M., Olson, Lyra B., Naqvi, Ibtehaj A., Morrison, Sarah A, Davis, Connor, Nimjee, Shahid M., Que, Loretta G., Bachelder, Robin E., Kraft, Bryan D., Chen, Lingye, Nair, Smita K., Levy, Jerrold H., Sullenger, Bruce A.

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Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis by Naqvi, Ibtehaj, Gunaratne, Ruwan, McDade, Jessica E., Moreno, Angelo, Rempel, Rachel E., Rouse, Douglas C., Herrera, Silvia Gabriela, Pisetsky, David S., Lee, Jaewoo, White, Rebekah R., Sullenger, Bruce A.

“…Nucleic acid binding polymers (NABPs) have been extensively used as vehicles for DNA and RNA delivery. More recently, we discovered that a subset of these…”
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Abstract 621: Serum circulating DNA and nucleosomes increase in response to neoadjuvant chemoradiation and surgical resection for pancreatic cancer by Naqvi, Ibtehaj A., Gunaratne, Ruwan, Pisetsky, David, White, Rebekah

“…Abstract Introduction: Pancreatic cancer (PC) is the deadliest of the major cancers, and response rates to standard therapies are low. Tumor cells release…”
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Abstract 4189: Cationic polymer inhibits pancreatic cancer invasion and metastasis by Naqvi, Ibtehaj A., Gunaratne, Ruwan, McDade, Jessica, Rouse, Douglas, Yeh, Jen Jen, Pisetsky, David, Lee, Jaewoo, White, Rebekah, Sullenger, Bruce

“…Abstract Background and Hypothesis: Pancreatic cancer (PC) has the poorest prognosis of all major cancers, with a 5-year survival of less than 5%. Cell-free…”
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