Search Results - "Naoyuki NAKADA"

Applications of MALDI mass spectrometry imaging for pharmacokinetic studies during drug development by Nishidate, Masanobu, Hayashi, Mitsuhiro, Aikawa, Hiroaki, Tanaka, Kouji, Nakada, Naoyuki, Miura, Shin-ichi, Ryu, Shoraku, Higashi, Tatsuya, Ikarashi, Yoshinori, Fujiwara, Yasuhiro, Hamada, Akinobu

“…The concentration and distribution of a drug or its metabolites in tissues are key factors for understanding drug efficacy or toxicity. Conventional…”
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Imaging Mass Spectrometry (IMS) for drug discovery and development survey: Results on methods, applications and regulatory compliance by Solon, Eric, Groseclose, M. Reid, Ho, Stacy, Tanaka, Kouji, Nakada, Naoyuki, Linehan, Stefan, Nishidate, Masanobu, Yokoi, Hiroyuki, Kaji, Hidefumi, Urasaki, Yoko, Watanabe, Kenichi, Ishida, Tomomi, Komatsu, Rika, Yoshida, Kenji, Yamazaki, Hiroshi, Saito, Kosuke, Saito, Yoshiro, Tanaka, Yukari

“…Imaging mass spectrometry (IMS) is increasingly used for drug discovery and development to understand target enagement, tissue distribution, drug toxicity, and…”
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A phase I, open-label, single-dose micro tracer mass balance study of 14C-labeled ASP7991 in healthy Japanese male subjects using accelerator mass spectrometry by Miyatake, Daisuke, Nakada, Naoyuki, Takada, Akitsugu, Kato, Kota, Taniuchi, Yuta, Katashima, Masataka, Sawamoto, Taiji

“…ASP7991 is a calcimimetic that acts on the calcium-sensing receptor on parathyroid cell membranes and suppresses parathyroid hormone (PTH) secretion in the…”
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A phase I, open-label, single-dose micro tracer mass balance study of 14 C-labeled ASP7991 in healthy Japanese male subjects using accelerator mass spectrometry by Miyatake, Daisuke, Nakada, Naoyuki, Takada, Akitsugu, Kato, Kota, Taniuchi, Yuta, Katashima, Masataka, Sawamoto, Taiji

“…ASP7991 is a calcimimetic that acts on the calcium-sensing receptor on parathyroid cell membranes and suppresses parathyroid hormone (PTH) secretion in the…”
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Human mass balance, metabolite profile and identification of metabolic enzymes of [14C]ASP015K, a novel oral janus kinase inhibitor by Oda, Kazuo, Cao, Ying J., Sawamoto, Taiji, Nakada, Naoyuki, Fisniku, Ogert, Nagasaka, Yasuhisa, Sohda, Kin-ya

“…1. The human mass balance of 14 C-labelled ASP015K ([ 14 C]ASP015K), an orally bioavailable Janus kinase (JAK) inhibitor, was characterized in six healthy male…”
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Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites by Kamimura, Hidetaka, Nakada, Naoyuki, Suzuki, Katsuhiro, Mera, Ayako, Souda, Kinya, Murakami, Yuichi, Tanaka, Kohichiro, Iwatsubo, Takafumi, Kawamura, Akio, Usui, Takashi

“…The ability to predict circulating human metabolites of a candidate drug before first-in-man studies are carried out would provide a clear advantage in drug…”
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Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in japanese by GOTO, Shuji, SEO, Takayuki, MURATA, Tsukasa, NAKADA, Naoyuki, UEDA, Nao, ISHITSU, Takateru, NAKAGAWA, Kazuko

“…A nonlinear mixed-effect modeling (NONMEM) program was used to evaluate the effects of cytochrome P450 (CYP) 2C9 and CYP2C19 polymorphisms on the phenobarbital…”
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Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2 by Nakada, Naoyuki

“…Purpose YM543 is a novel selective inhibitor of the sodium-glucose cotransporter 2. The objectives of the current study were to evaluate the utility of mice…”
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Cell tracking of chromium‐labeled mesenchymal stem cells using laser ablation inductively coupled plasma imaging mass spectrometry by Nakada, Naoyuki, Kuroki, Yasuo

“…Rationale Mesenchymal stem cells (MSCs) are widely used in regenerative medicine research. Evaluating the biodistribution of MSCs is important for determining…”
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Interactive Effect of Paraoxonase-1 Q192R Polymorphism and Smoking History on the Lung Function Decline in Grain Workers by Seo, Takayuki, MS, Pahwa, Punam, PhD, McDuffie, Helen H., PhD, Nakada, Naoyuki, MS, Goto, Shuji, MS, Ghosh, Sunita, MS, Nakagawa, Kazuko, MD, PhD

“…Purpose This retrospective longitudinal study investigated the association between the Q192R polymorphism of the high-density lipoprotein–associated…”
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GaN on Si Substrate with AlGaN/AlN Intermediate Layer by Ishikawa, Hiroyasu, Zhao, Guang-Yuan, Nakada, Naoyuki, Egawa, Takashi, Jimbo, Takashi, Umeno, Masayoshi

“…A single crystal GaN thin film was successfully grown on a Si (111) substrate by means of atmospheric pressure metalorganic chemical vapor deposition. Though…”
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Phenotype-genotype analysis of CYP1A2 in Japanese patients receiving oral theophylline therapy by TAKATA, Keiji, SARUWATARI, Junji, NAKADA, Naoyuki, NAKAGAWA, Mizuna, FUKUDA, Koichiro, TANAKA, Fujiho, TAKENAKA, Shinobu, MIHARA, Shuichi, MARUBAYASHI, Toru, NAKAGAWA, Kazuko

“…To clarify the association between the cytochrome P450 (CYP) 1A2 genotype with the CYP1A2 phenotype and to search for the CYP1A2*1K haplotype, which has been…”
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Investigation of Metabolite Profile of YM758, a Novel If Channel Inhibitor by Nakada, Naoyuki

“…Background YM758 monophosphate is a novel If channel inhibitor that has an inhibitory action for If current and shows a strong and specific activity,…”
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Suppression of Crack Generation in GaN/AlGaN Distributed Bragg Reflector on Sapphire by the Insertion of GaN/AlGaN Superlattice Grown by Metal-Organic Chemical Vapor Deposition by Nakada, Naoyuki, Ishikawa, Hiroyasu, Egawa, Takashi, Jimbo, Takashi

“…GaN/AlGaN distributed Bragg reflectors (DBRs) have been grown on sapphire by MOCVD. A GaN/AlGaN superlattice (SL) was introduced prior to the growth of the DBR…”
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Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans by Nakada, Naoyuki, Oda, Kazuo

“…1. Here, we elucidated the structure of metabolites of novel oral Janus kinase inhibitor ASP015K in rats and humans and evaluated the predictability of human…”
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MOCVD growth of high reflective GaN/AlGaN distributed Bragg reflectors by Nakada, Naoyuki, Ishikawa, Hiroyasu, Egawa, Takashi, Jimbo, Takashi, Umeno, Masayoshi

“…GaN/AlGaN distributed Bragg reflectors have been grown by low-pressure metal organic chemical vapor deposition. Those structures were fabricated on the…”
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Correlation between Electrical and Surface Properties of n-GaN on Sapphire Grown by Metal-Organic Chemical Vapor Deposition by Nakada, Naoyuki, Mori, Masayoshi, Ishikawa, Hiroyasu, Egawa, Takashi, Jimbo, Takashi

“…Lightly doped n-GaN epilayers were grown by MOCVD on sapphire substrates. The grown n-GaN epilayers were characterized using AFM, XRD, photoluminescence and…”
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Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites by Hidetaka KAMIMURA, Naoyuki NAKADA, Katsuhiro SUZUKI, Ayako MERA, Kinya SOUDA, Yuichi MURAKAMI, Kohichiro TANAKA, Takafumi IWATSUBO, Akio KAWAMURA, Takashi USUI

“…Summary: The ability to predict circulating human metabolites of a candidate drug before first-in-man studies are carried out would provide a clear advantage…”
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Suppression of GaInN/GaN Multi-Quantum-Well Decomposition during Growth of Light-Emitting-Diode Structure by Ishikawa, Hiroyasu, Nakada, Naoyuki, Mori, Masayoshi, Zhao, Guan-Yuan, Egawa, Takashi, Jimbo, Takashi, Umeno, Masayoshi

“…Growth of GaN-based light-emitting-diode (LED) structures with GaInN/GaN multi-quantum wells (MQWs) has been explored by metalorganic chemical vapor…”
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In vitro/in vivo investigations to examine the gender differences in the pharmacokinetics of novel oral Janus kinase (JAK) inhibitor ASP015K and sulfate metabolite M2 in rats by Oda, Kazuo, Nakada, Naoyuki, Nagasaka, Yasuhisa

“…Abstract 1. Although marked gender differences have been reported for the exposure level of the sulfate metabolite M2 of ASP015K in rats, no such differences…”
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