Search Results - "Naoyuki Kawao"

Interactions Between Muscle Tissues and Bone Metabolism by Kawao, Naoyuki, Kaji, Hiroshi

“…ABSTRACT Sarcopenia and osteoporosis have recently been noted for their relationship with locomotive syndrome and increased number of older people. Sarcopenia…”
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Roles of Irisin in the Linkage from Muscle to Bone During Mechanical Unloading in Mice by Kawao, Naoyuki, Moritake, Akihiro, Tatsumi, Kohei, Kaji, Hiroshi

“…Mechanical unloading induces disuse muscle atrophy and bone loss, but the details in mechanism involved in those pathophysiological conditions are not fully…”
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Role of irisin in effects of chronic exercise on muscle and bone in ovariectomized mice by Kawao, Naoyuki, Iemura, Shunki, Kawaguchi, Miku, Mizukami, Yuya, Takafuji, Yoshimasa, Kaji, Hiroshi

“…Introduction Exercise is beneficial for the prevention and treatment of osteoporosis. Skeletal muscle affects other tissues via myokines, the release of which…”
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Role of irisin in androgen-deficient muscle wasting and osteopenia in mice by Iemura, Shunki, Kawao, Naoyuki, Okumoto, Katsumi, Akagi, Masao, Kaji, Hiroshi

“…Androgen deficiency plays a crucial role in the pathogenesis of male osteoporosis and sarcopenia. Myokines have recently been identified as humoral factors…”
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Role of follistatin in muscle and bone alterations induced by gravity change in mice by Kawao, Naoyuki, Morita, Hironobu, Obata, Koji, Tatsumi, Kohei, Kaji, Hiroshi

“…Interactions between muscle and bone have been recently noted. We reported that the vestibular system plays crucial roles in the changes in muscle and bone…”
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Roles of leptin in the recovery of muscle and bone by reloading after mechanical unloading in high fat diet-fed obese mice by Kawao, Naoyuki, Ishida, Masayoshi, Kaji, Hiroshi

“…Muscle and bone masses are elevated by the increased mechanical stress associated with body weight gain in obesity. However, the mechanisms by which obesity…”
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Effects of elastase-induced emphysema on muscle and bone in mice by Matsumura, Daichi, Kawao, Naoyuki, Okumoto, Katsumi, Ohira, Takashi, Mizukami, Yuya, Akagi, Masao, Kaji, Hiroshi

“…Chronic obstructive pulmonary disease (COPD) causes sarcopenia and osteoporosis. However, the mechanisms underlying muscle and bone loss as well as the…”
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MicroRNA-196a-5p in Extracellular Vesicles Secreted from Myoblasts Suppresses Osteoclast-like Cell Formation in Mouse Cells by Takafuji, Yoshimasa, Tatsumi, Kohei, Kawao, Naoyuki, Okada, Kiyotaka, Muratani, Masafumi, Kaji, Hiroshi

“…Muscle/bone interaction has been recently noted. Extracellular vesicles (EVs) play a vital role in physiological and pathophysiological processes by…”
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Roles of Dkk2 in the Linkage from Muscle to Bone during Mechanical Unloading in Mice by Kawao, Naoyuki, Morita, Hironobu, Iemura, Shunki, Ishida, Masayoshi, Kaji, Hiroshi

“…Mechanical unloading simultaneously induces muscle and bone loss, but its mechanisms are not fully understood. The interactions between skeletal muscle and…”
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Roles of Olfactomedin 1 in Muscle and Bone Alterations Induced by Gravity Change in Mice by Shimoide, Takeshi, Kawao, Naoyuki, Morita, Hironobu, Ishida, Masayoshi, Takafuji, Yoshimasa, Kaji, Hiroshi

“…Microgravity causes both muscle and bone loss. Although we previously revealed that gravity change influences muscle and bone through the vestibular system in…”
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Effects of fluid flow shear stress to mouse muscle cells on the bone actions of muscle cell-derived extracellular vesicless by Takafuji, Yoshimasa, Tatsumi, Kohei, Kawao, Naoyuki, Okada, Kiyotaka, Muratani, Masafumi, Kaji, Hiroshi

“…The interactions between skeletal muscle and bone have been recently noted, and muscle-derived humoral factors related to bone metabolism play crucial roles in…”
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Matrix vesicles promote bone repair after a femoral bone defect in mice by Mizukami, Yuya, Kawao, Naoyuki, Takafuji, Yoshimasa, Ohira, Takashi, Okada, Kiyotaka, Jo, Jun-Ichiro, Tabata, Yasuhiko, Kaji, Hiroshi

“…Matrix vesicles (MtVs) are one of the extracellular vesicles (EVs) secreted by osteoblasts. Although MtVs have a classically-defined function as an initiator…”
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Role of Dkk2 in the Muscle/bone Interaction of Androgen-Deficient Mice by Iemura, Shunki, Kawao, Naoyuki, Akagi, Masao, Kaji, Hiroshi

“…Androgen deficiency is known to cause both osteoporosis and sarcopenia. Myokines, humoral factors secreted from the skeletal muscles, have recently been…”
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Effects of Growth Hormone on Muscle and Bone in Female Mice: Role of Follistatin by Ohira, Takashi, Kawao, Naoyuki, Takafuji, Yoshimasa, Mizukami, Yuya, Kaji, Hiroshi

“…The interactions between muscle and bone are noted in the clinical relationships between sarcopenia and osteoporosis. Myokines secreted from the skeletal…”
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Extracellular vesicles secreted from mouse muscle cells improve delayed bone repair in diabetic mice by Takafuji, Yoshimasa, Kawao, Naoyuki, Ohira, Takashi, Mizukami, Yuya, Okada, Kiyotaka, Jo, Jun-Ichiro, Tabata, Yasuhiko, Kaji, Hiroshi

“…Humoral factors that are secreted from skeletal muscles can regulate bone metabolism and contribute to muscle-bone relationships. Although extracellular…”
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Plasminogen activator inhibitor‐1 deficiency suppresses osteoblastic differentiation of mesenchymal stem cells in mice by Takafuji, Yoshimasa, Tatsumi, Kohei, Ishida, Masayoshi, Kawao, Naoyuki, Okada, Kiyotaka, Matsuo, Osamu, Kaji, Hiroshi

“…Plasminogen activator inhibitor‐1 (PAI‐1) is known as an inhibitor of fibrinolytic system. Previous studies suggest that PAI‐1 is involved in the pathogenesis…”
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Renal failure suppresses muscle irisin expression, and irisin blunts cortical bone loss in mice by Kawao, Naoyuki, Kawaguchi, Miku, Ohira, Takashi, Ehara, Hiroki, Mizukami, Yuya, Takafuji, Yoshimasa, Kaji, Hiroshi

“…Background Chronic renal failure induces bone mineral disorders and sarcopenia. Skeletal muscle affects other tissues, including bone, by releasing myokines…”
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Novel roles of FKBP5 in muscle alteration induced by gravity change in mice by Shimoide, Takeshi, Kawao, Naoyuki, Tamura, Yukinori, Morita, Hironobu, Kaji, Hiroshi

“…Skeletal muscle hypertrophy and wasting are induced by hypergravity and microgravity, respectively. However, the mechanisms by which gravity change regulates…”
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Role of peripheral myelin protein 22 in chronic exercise‐induced interactions of muscle and bone in mice by Kawaguchi, Miku, Kawao, Naoyuki, Muratani, Masafumi, Takafuji, Yoshimasa, Ishida, Masayoshi, Kinoshita, Yuko, Takada, Yuto, Mizukami, Yuya, Ohira, Takashi, Kaji, Hiroshi

“…Exercise is important for the prevention and treatment of sarcopenia and osteoporosis. Although the interactions between skeletal muscles and bone have…”
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Role of plasminogen activator inhibitor-1 in glucocorticoid-induced diabetes and osteopenia in mice by Tamura, Yukinori, Kawao, Naoyuki, Yano, Masato, Okada, Kiyotaka, Okumoto, Katsumi, Chiba, Yasutaka, Matsuo, Osamu, Kaji, Hiroshi

“…Long-term use of glucocorticoids (GCs) causes numerous adverse effects, including glucose/lipid abnormalities, osteoporosis, and muscle wasting. The pathogenic…”
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