Presepsin in Human Milk Is Delivery Mode and Gender Dependent

Breast milk (BM) is a unique food due to its nutritional composition and anti-inflammatory characteristics. Evidence has emerged on the role of Presepsin (PSEP) as a reliable marker of early sepsis diagnosis. In the present study, we aimed to investigate the measurability of PSEP in BM according to...

Full description

Saved in:

Bibliographic Details
Published in:	Nutrients Vol. 16; no. 15; p. 2554
Main Authors:	D'Adamo, Ebe, Peila, Chiara, Strozzi, Mariachiara, Barolo, Roberta, Maconi, Antonio, Nanni, Arianna, Botondi, Valentina, Coscia, Alessandra, Bertino, Enrico, Gazzolo, Francesca, Abdelhameed, Ali Saber, Conte, Mariangela, Picone, Simonetta, D'Andrea, Marianna, Lizzi, Mauro, Quarta, Maria Teresa, Gazzolo, Diego
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-08-2024
Subjects:	Adult Apgar score Asphyxia neonatorum Biomarkers - analysis Blood Breast feeding Breastfeeding & lactation breastmilk Case-Control Studies Delivery, Obstetric Female Gender Gestational age Glycoproteins Gram-positive bacteria Humans Hypoxia Infant, Newborn Infant, Premature Lipopolysaccharide Receptors - metabolism Male Milk, Human - chemistry newborn Newborn babies nutrition Peptide Fragments - analysis Population Pregnancy presepsin preterm Prospective Studies sCD14 Sepsis Sex Factors Statistical analysis presepsin preterm nutrition sCD14 newborn breastmilk
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Breast milk (BM) is a unique food due to its nutritional composition and anti-inflammatory characteristics. Evidence has emerged on the role of Presepsin (PSEP) as a reliable marker of early sepsis diagnosis. In the present study, we aimed to investigate the measurability of PSEP in BM according to different maturation stages (colostrum, C; transition, Tr; and mature milks, Mt) and corrected for delivery mode and gender. We conducted a multicenter prospective case-control study in women who had delivered 22 term (T) and 22 preterm (PT) infants. A total of 44 human milk samples were collected and stored at -80 °C. BM PSEP (pg/mL) levels were measured by using a rapid chemiluminescent enzyme immunoassay. PSEP was detected in all samples analyzed. Higher ( < 0.05) BM PSEP concentrations were observed in the PT compared to the T infants. According to the grade of maturation, higher ( < 0.05) levels of PSEP in C compared to Tr and Mt milks were observed in the whole study population. The BM subtypes' degrees of maturation were delivery mode and gender dependent. We found that PSEP at high concentrations supports its antimicrobial action both in PT and T infants. These results open the door to further studies investigating the role of PSEP.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu16152554