Search Results - "Nanji, AA"

Pathogenesis of Alcoholic Liver Disease-Recent Advances by Nanji, Amin A., Su, Grace L., Laposata, Michael, French, Samuel W.

“…The article summarizes the proceedings of a symposium on recent advances in research on the pathogenesis of alcoholic liver disease at the 2001 RSA meeting in…”
Get full text

Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes by Nanji, Amin A, Jokelainen, Kalle, Tipoe, George L, Rahemtulla, Amir, Thomas, Peter, Dannenberg, Andrew J

“…Induction of NF-kappaB-mediated gene expression has been implicated in the pathogenesis of alcoholic liver disease (ALD). Curcumin, a phenolic antioxidant,…”
Get more information

Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants by Chen, Ju-Hua, Tipoe, George L, Liong, Emily C, So, Henry S H, Leung, Ka-Man, Tom, Wai-Ming, Fung, Peter C W, Nanji, Amin A

“…Recently, considerable attention has been focused on dietary and medicinal phytochemicals that inhibit, reverse, or retard diseases caused by oxidative and…”
Get full text

Role of different dietary fatty acids in the pathogenesis of experimental alcoholic liver disease by Nanji, Amin A.

“…Both dietary fatty acids and alcohol play an important role in the pathogenesis of alcoholic liver disease. Findings of studies in rats show a steatogenic role…”
Get full text

Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin, and chemokines by Nanji, A A, Jokelainen, K, Fotouhinia, M, Rahemtulla, A, Thomas, P, Tipoe, G L, Su, G L, Dannenberg, A J

“…Alcoholic liver injury is more severe and rapidly developing in women than men. To evaluate the reason(s) for these gender-related differences, we determined…”
Get more information

Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil by Polavarapu, Rathnagiri, Spitz, Douglas R., Sim, Julia E., Follansbee, Mark H., Oberley, Larry W., Rahemtulla, Amir, Nanji, Amin A.

“…Increased hepatic oxidative stress with ethanol administration is hypothesized to be caused either by enhanced pro‐oxidant production or decreased levels of…”
Get full text

Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat by Nanji, Amin A., Jokelainen, Kalle, Rahemtulla, Amir, Miao, Lili, Fogt, Franz, Matsumoto, Hiroshi, Tahan, Steven R., Su, Grace L.

“…Inflammatory stimuli and lipid peroxidation activate nuclear factor kappa B (NF‐κB) and upregulate proinflammatory cytokines and chemokines. The present study…”
Get full text

Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration by Nanji, A A, Jokelainen, K, Tipoe, G L, Rahemtulla, A, Dannenberg, A J

“…We investigated the potential of dietary saturated fatty acids to reverse alcoholic liver injury despite continued administration of alcohol. Five groups (six…”
Get more information

Induction of CYP3A by Ethanol in multiple In vitro and In vivo models by FEIERMAN, Dennis E, MELINKOV, Zoya, NANJI, Amin A

“…Cytochrome P-450 3A (CYP3A) is responsible for the metabolism of numerous therapeutic agents. The content of CYP3A seems to be affected by ethanol ingestion…”
Get full text

Apoptosis and alcoholic liver disease by Nanji, A A

“…Apoptosis occurs in both clinical and experimental alcoholic liver disease. The mechanisms involved in alcohol-induced apoptosis of liver cells are not…”
Get more information

Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease) by Nanji, A A, Khettry, U, Sadrzadeh, S M

“…We have previously shown a relationship between plasma endotoxin levels and severity of alcoholic liver injury in the intragastric feeding rat model. We…”
Get more information

NF-κB ACTIVATION IS ASSOCIATED WITH FREE RADICAL GENERATION AND ENDOTOXEMIA AND PRECEDES PATHOLOGICAL LIVER INJURY IN EXPERIMENTAL ALCOHOLIC LIVER DISEASE by Jokelainen, Kalle, Reinke, Lester A., Nanji, Amin A.

“…Endotoxemia and oxidative stress activate nuclear factor kappa B (NF-κB) in alcoholic liver injury. In alcohol-fed rats, activation of NF-κB is associated with…”
Get full text

Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat by Nanji, AA, Miao, L, Thomas, P, Rahemtulla, A, Khwaja, S, Zhao, S, Peters, D, Tahan, SR, Dannenberg, AJ

“…BACKGROUND & AIMS: Inflammatory stimuli and lipid peroxidation up- regulate cyclooxygenase (COX)-2. This study evaluated the relationship between inflammatory…”
Get full text

Role of Kupffer cells in alcoholic hepatitis by Nanji, Amin A.

“…Kupffer cells play a major role in alcoholic liver disease. Oxidative stress and endotoxin are major mediators of the inflammatory process in alcoholic…”
Get full text

Another animal model for nonalcoholic steatohepatitis: how close to the human condition? by Nanji, A.A

“…The relation between oxidative stress and the induction of cytochrome P450, particularly the 2E1 isoform, provides a plausible explanation for hepatic damage…”
Get full text

Decreased Proteasome Activity Is Associated With Increased Severity of Liver Pathology and Oxidative Stress in Experimental Alcoholic Liver Disease by Donohue Jr, Terrence M., Kharbanda, Kusum K., Casey, Carol A., Nanji, Amin A.

“…Background: Because of its role in degrading the bulk of intracellular proteins and eliminating damaged proteins, the proteasome is important in maintaining…”
Get full text

Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration by Nanji, A A, Jokelainen, K, Lau, G K, Rahemtulla, A, Tipoe, G L, Polavarapu, R, Lalani, E N

“…We investigated the potential of arginine to reverse pathological changes in alcohol-induced liver injury. Four groups (six rats/group) of male Wistar rats…”
Get more information

Acetaldehyde-modified and 4-hydroxynonenal-modified proteins in the livers of rats with alcoholic liver disease by Li, C, Nanji, AA, Siakotos, AN, Lin, RC

“…Liver proteins form adducts with acetaldehyde and are modified by products of lipid peroxidation in alcohol-fed animals. It has been hypothesized that the…”
Get full text

Severity of liver injury in experimental alcoholic liver disease. Correlation with plasma endotoxin, prostaglandin E2, leukotriene B4, and thromboxane B2 by Nanji, AA, Khettry, U, Sadrzadeh, SM, Yamanaka, T

“…The purpose of our study is to determine if a relationship exists between the severity of injury in experimental alcoholic liver disease and plasma levels of…”
Get full text

Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats by Nanji, A A, Zhao, S, Sadrzadeh, S M, Dannenberg, A J, Tahan, S R, Waxman, D J

“…We evaluated the role of changes in cytochrome P-450 2E1 (CYP 2E1) and lipid peroxidation in relation to development of severe liver injury in fish…”
Get more information