Search Results - "Nani, João V."

Peering into the mind: unraveling schizophrenia's secrets using models by Nani, João V, Muotri, Alysson R, Hayashi, Mirian A F

“…Schizophrenia (SCZ) is a complex mental disorder characterized by a range of symptoms, including positive and negative symptoms, as well as cognitive…”
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Angiotensin‐converting enzymes as druggable features of psychiatric and neurodegenerative disorders by Santiago, Thays Calista, Parra, Larissa, Nani, João V., Fidalgo, Thiago M., Bradshaw, Nicholas J., Hayashi, Mirian A. F.

“…The renin‐angiotensin system (RAS) plays essential roles in maintaining peripheral cardiovascular homeostasis, with its potential roles in the brain only being…”
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Assessing the role of Ndel1 oligopeptidase activity in congenital Zika syndrome: Potential predictor of congenital syndrome endophenotype and treatment response by Christoff, Raissa R., Nani, João V., Lessa, Gabriel, Rabello, Tailene, Rossi, Atila D., Krenn, Veronica, Higa, Luiza M., Tanuri, Amilcar, Garcez, Patricia P., Hayashi, Mirian A. F.

“…Maternal infections are among the main risk factors for cognitive impairments in the offspring. Zika virus (ZIKV) can be transmitted vertically, causing a set…”
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Identification of an ex vivo inhibitor of the schizophrenia biomarker Ndel1 by high throughput screening by Nani, João V., Coelho, Camila, Oyadomari, William Y., Santiago, Thays Calista, Machado, Marcelo Marcondes, Christoff, Raissa R., Garcez, Patrícia P., Oliveira, Vitor, Würtele, Martin, Hayashi, Mirian A.F.

“…[Display omitted] Ndel1 oligopeptidase activity shows promise as a potential biomarker for diagnosing schizophrenia (SCZ) and monitoring early-stage…”
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Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia by Dal Mas, Caroline, Nani, João V., Noto, Cristiano, Yonamine, Camila M., da Cunha, Graccielle Rodrigues, Mansur, Rodrigo B., Ota, Vanessa K., Belangero, Sintia Iole, Cordeiro, Quirino, Kapczinski, Flávio, Brietzke, Elisa, Bressan, Rodrigo A., Gadelha, Ary, Hayashi, Mirian A.F.

“…Our previous studies showed reduced Ndel1 enzyme activity in patients with chronic schizophrenia (SCZ), and only a subtle NDEL1 mRNA increases in…”
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Evaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophrenia: effects of psychostimulants and antipsychotics by Nani, João V., Lee, Richard S., Yonamine, Camila M., Sant’Anna, Osvaldo A., Juliano, Maria A., Gadelha, Ary, Mari, Jair J., Hayashi, Mirian A. F.

“…Nuclear distribution element-like 1 (NDEL1) enzyme activity is important for neuritogenesis, neuronal migration, and neurodevelopment. We reported previously…”
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ACE activity in blood and brain axis in an animal model for schizophrenia: Effects of dopaminergic manipulation with antipsychotics and psychostimulants by Nani, João V., Yonamine, Camila M., Castro Musial, Diego, Dal Mas, Caroline, Mari, Jair J., Hayashi, Mirian A. F.

“…Objectives: Angiotensin I-converting enzyme (ACE) was initially correlated with schizophrenia (SCZ) in studies showing a correlation of ACE increased enzyme…”
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Infection by zika virus increase angiotensin I-converting enzyme activity in mouse brain by Oyadomari, William Y., Christoff, Raissa R., Nani, João V., Rabello, Tailene, Oliveira, Vitor, Higa, Luiza M., Garcez, Patrícia P., Hayashi, Mirian A.F.

“…Congenital zika virus syndrome (CZS) has become a significant worldwide concern since the sudden rise of microcephaly related to zika virus (ZIKV) in Brazil…”
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Evaluation of tumor growth remission in a murine model for subcutaneous solid tumors – Benefits of associating the antitumor agent crotamine with mesoporous nanosilica particles to achieve improved dosing frequency and efficacy by Oyadomari, William Yoshio, Anthero, Gabriel Lessa, Silva, Marcos R. de A., Porta, Lucas C., Oliveira, Vitor, Reid, Paul F., Sant'Anna, Osvaldo A., Alves, Wendel A., Nani, João V., Hayashi, Mirian Akemi Furuie

“…[Display omitted] Crotamine is a highly cationic polypeptide first isolated from South American rattlesnake venom, which exhibits affinity for acidic lysosomal…”
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Euthymic and depressed bipolar patients are characterized by different RNA editing patterns in blood by Hayashi, Mirian A.F., Salvetat, Nicolas, Cayzac, Christopher, Checa-Robles, Francisco Jesus, Dubuc, Benjamin, Mereuze, Sandie, Nani, João V., Molina, Franck, Brietzke, Elisa, Weissmann, Dinah

“…•The diagnostic value of a panel of RNA editing-based blood biomarkers was confirmed.•The validity of this panel for diagnosis was confirmed in an independent…”
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Peripheral biomarkers allow differential diagnosis between schizophrenia and bipolar disorder by Tasic, Ljubica, Larcerda, Acioly L.T., Pontes, João G.M., da Costa, Tássia B.B. C., Nani, João V., Martins, Lucas Gelain, Santos, Leonardo A., Nunes, Marielle F.Q., Adelino, Marcelo P.M., Pedrini, Mariana, Cordeiro, Quirino, Bachion de Santana, Felipe, Poppi, Ronei J., Brietzke, Elisa, Hayashi, Mirian Akemi Furuie

“…Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders that pose important challenges for diagnosis by sharing common symptoms, such as…”
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Regulation of monoamine levels by typical and atypical antipsychotics in Caenorhabditis elegans mutant for nuclear distribution element genes by Campeiro, Joana D'Arc, Nani, João V., Monte, Gabriela G., Almeida, Priscila G.C., Mori, Marcelo A., Hayashi, Mirian A.F.

“…Mammalian nuclear distribution genes encode proteins with essential roles in neuronal migration and brain formation during embryogenesis. The implication of…”
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A Study in First-Episode Psychosis Patients: Does Angiotensin I-Converting Enzyme Activity Associated With Genotype Predict Symptom Severity Reductions After Treatment With Atypical Antipsychotic Risperidone? by Nani, João V, Dal Mas, Caroline, Yonamine, Camila M, Ota, Vanessa K, Noto, Cristiano, Belangero, Sintia I, Mari, Jair J, Bressan, Rodrigo, Cordeiro, Quirino, Gadelha, Ary, Hayashi, Mirian A F

“…Abstract Background Our previous studies showed increased angiotensin I-converting enzyme (ACE) activity in chronic schizophrenia patients compared with…”
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A system biology approach based on metabolic biomarkers and protein–protein interactions for identifying pathways underlying schizophrenia and bipolar disorder by Altaf-Ul-Amin, Md, Hirose, Kazuhisa, Nani, João V., Porta, Lucas C., Tasic, Ljubica, Hossain, Shaikh Farhad, Huang, Ming, Ono, Naoaki, Hayashi, Mirian A. F., Kanaya, Shigehiko

“…Mental disorders (MDs), including schizophrenia (SCZ) and bipolar disorder (BD), have attracted special attention from scientists due to their high prevalence…”
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Decreased nuclear distribution nudE-like 1 enzyme activity in an animal model with dysfunctional disrupted-in-schizophrenia 1 signaling featuring aberrant neurodevelopment and amphetamine-supersensitivity by Nani, João V, Fonseca, Matheus C, Engi, Sheila A, Perillo, Mayara G, Dias, Carlos SB, Gazarini, Marcos L, Korth, Carsten, Cruz, Fábio C, Hayashi, Mirian AF

“…Background: Interaction of nuclear-distribution element-like 1 with disrupted-in-schizophrenia 1 protein is crucial for neurite outgrowth/neuronal migration,…”
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Unraveiling the correlation among neurodevelopmental and inflammatory biomarkers in patients with chronic schizophrenia by Nani, João V., Almeida, Priscila G. C, Noto, Cristiano, Bressan, Rodrigo A., Brietzke, Elisa, Hayashi, Mirian A. F

“…INTRODUCTIONNuclear distribution element like-1 (Ndel1) is a cytosolic oligopeptidase, which was suggested as a potential biomarker of aberrant…”
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Impact of nuclear distribution element genes in the typical and atypical antipsychotics effects on nematode Caenorhabditis elegans: Putative animal model for studying the pathways correlated to schizophrenia by Monte, Gabriela Guilherme, Nani, João V., de Almeida Campos, Marina Rosseto, Dal Mas, Caroline, Marins, Lucas Augusto Negri, Martins, Lucas Gelain, Tasic, Ljubica, Mori, Marcelo A., Hayashi, Mirian A.F.

“…The nuclear distribution element genes are conserved from fungus to humans. The nematode Caenorhabditis elegans expresses two isoforms of nuclear distribution…”
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Prolyl oligopeptidase activity (POP) in early stage and medicated schizophrenia and in an animal model for schizophrenia study: In vivo effects of psychopharmacological substances on enzyme activity by Marins, Lucas A.N., Rodríguez, Benjamín, Nani, João V., Oliveira, Vitor, Gadelha, Ary, Hayashi, Mirian A.F.

“…•POP activity is similar in patients in early stage or with chronic schizophrenia.•POP activity is similar between healthy control and patients with…”
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Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms by Courchesne, Eric, Taluja, Vani, Nazari, Sanaz, Aamodt, Caitlin M, Pierce, Karen, Duan, Kuaikuai, Stophaeros, Sunny, Lopez, Linda, Barnes, Cynthia Carter, Troxel, Jaden, Campbell, Kathleen, Wang, Tianyun, Hoekzema, Kendra, Eichler, Evan E, Nani, Joao V, Pontes, Wirla, Sanchez, Sandra Sanchez, Lombardo, Michael V, de Souza, Janaina S, Hayashi, Mirian A F, Muotri, Alysson R

“…Social affective and communication symptoms are central to autism spectrum disorder (ASD), yet their severity differs across toddlers: Some toddlers with ASD…”
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A study in first-episode psychosis patients: does angiotensin I-converting enzyme (ACE) activity associated with genotype predict symptoms severity reductions after treatment with the atypical antipsychotic risperidone? by Nani, João V, Dal Mas, Caroline, Yonamine, Camila M, Ota, Vanessa K, Noto, Cristiano, Belangero, Sintia I, Mari, Jair J, Bressan, Rodrigo, Cordeiro, Quirino, Gadelha, Ary, Hayashi, Mirian A F

“…Our previous studies showed increased angiotensin I-converting enzyme (ACE) activity in chronic schizophrenia (SCZ) patients compared to healthy control (HC)…”
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