Search Results - "Nandurkar, H. H."

Ibrutinib inhibits collagen-mediated but not ADP-mediated platelet aggregation by Kamel, S, Horton, L, Ysebaert, L, Levade, M, Burbury, K, Tan, S, Cole-Sinclair, M, Reynolds, J, Filshie, R, Schischka, S, Khot, A, Sandhu, S, Keating, M J, Nandurkar, H, Tam, C S

“…The BTK (Bruton’s tyrosine kinase) inhibitor ibrutinib is associated with an increased risk of bleeding. A previous study reported defects in collagen- and…”
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New oral anticoagulants: a practical guide on prescription, laboratory testing and peri-procedural/bleeding management by Tran, H., Joseph, J., Young, L., McRae, S., Curnow, J., Nandurkar, H., Wood, P., McLintock, C.

“…New oral anticoagulants (NOAC) are becoming available as alternatives to warfarin to prevent systemic embolism in patients with non‐valvular atrial…”
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Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding? by Hohmann, Jan David, Wang, Xiaowei, Krajewski, Stefanie, Selan, Carly, Haller, Carolyn A., Straub, Andreas, Chaikof, Elliot L., Nandurkar, Harshal H., Hagemeyer, Christoph E., Peter, Karlheinz

“…The ecto-nucleoside triphosphate diphosphohydrolase CD39 represents a promising antithrombotic therapeutic. It degrades adenosine 5′-diphosphate (ADP), a main…”
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Role of Purinergic Signalling in Endothelial Dysfunction and Thrombo-Inflammation in Ischaemic Stroke and Cerebral Small Vessel Disease by Lee, Natasha Ting, Ong, Lin Kooi, Gyawali, Prajwal, Nassir, Che Mohd Nasril Che Mohd, Mustapha, Muzaimi, Nandurkar, Harshal H., Sashindranath, Maithili

“…The cerebral endothelium is an active interface between blood and the central nervous system. In addition to being a physical barrier between the blood and the…”
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Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation by Robb, Lorraine, Li, Ruili, Hartley, Lynne, Nandurkar, Harshal H, Koentgen, Frank, Begley, C. Glenn

“…During early pregnancy, in response to the implanting embryo, the surrounding uterine stroma undergoes a dramatic transformation into a specialized tissue…”
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Transgenic Overexpression of CD39 Protects Against Renal Ischemia‐Reperfusion and Transplant Vascular Injury by Crikis, S., Lu, B., Murray‐Segal, L. M., Selan, C., Robson, S. C., D’Apice, A. J. F., Nandurkar, H. H., Cowan, P. J., Dwyer, K. M.

“…The vascular ectonucleotidases CD39[ENTPD1 (ectonucleoside triphosphate diphosphohydrolase‐1), EC 3.6.1.5] and CD73[EC 3.1.3.5] generate adenosine from…”
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Endothelial Dysfunction in the Brain: Setting the Stage for Stroke and Other Cerebrovascular Complications of COVID-19 by Sashindranath, Maithili, Nandurkar, Harshal H.

“…The Coronavirus disease 2019 (COVID)-19 pandemic has already affected millions worldwide, with a current mortality rate of 2.2%. While it is well-established…”
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Pig Thrombomodulin Binds Human Thrombin but Is a Poor Cofactor for Activation of Human Protein C and TAFI by Roussel, J. C., Moran, C. J., Salvaris, E. J., Nandurkar, H. H., D'Apice, A. J. F., Cowan, P. J.

“…Incompatibility between pig thrombomodulin (TM) and primate thrombin is thought to be an important factor in the development of microvascular thrombosis in…”
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Ten years of cerebral venous thrombosis: male gender and myeloproliferative neoplasm is associated with thrombotic recurrence in unprovoked events by Lim, H. Y., Ng, C., Donnan, G., Nandurkar, H., Ho, Prahlad

“…Cerebral venous thrombosis (CVT) is a rare venous thrombotic event. We review our local experience in the management of CVT in comparison to other venous…”
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Early Endothelial Activation in a Mouse Model of Graft vs Host Disease Following Chemotherapy by Pereira, Melrine, Lee, Natasha Ting, Noonan, Jonathan, Willcox, Abbey E H, Calvello, Ilaria, Georgy, Smitha Rose, Selan, Carly, Chia, Joanne S, Hauw, Wayne, Wang, Xiaowei, Peter, Karlheinz, Robson, Simon C, Nandurkar, Harshal H, Sashindranath, Maithili

“…Allogenic hematopoietic stem cell transplant (allo-HSCT) can lead to sinusoidal obstruction syndrome (SOS) and graft-versus-host disease (GvHD) in some…”
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Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation by Dwyer, Karen M, Robson, Simon C, Nandurkar, Harshal H, Campbell, Duncan J, Gock, Hilton, Murray-Segal, Lisa J, Fisicaro, Nella, Mysore, Tharun B, Kaczmarek, Elzbieta, Cowan, Peter J, d'Apice, Anthony J F

“…Extracellular nucleotides play an important role in thrombosis and inflammation, triggering a range of effects such as platelet activation and recruitment,…”
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myotubularin phosphatase MTMR4 regulates sorting from early endosomes by Naughtin, Monica J, Sheffield, David A, Rahman, Parvin, Hughes, William E, Gurung, Rajendra, Stow, Jennifer L, Nandurkar, Harshal H, Dyson, Jennifer M, Mitchell, Christina A

“…Phosphatidylinositol 3-phosphate [PtdIns(3)P] regulates endocytic trafficking and the sorting of receptors through early endosomes, including the rapid…”
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Prevalence and predictors of fatigue in haemo-oncological patients by Zordan, R., Manitta, V., Nandurkar, H., Cole-Sinclair, M., Philip, J.

“…Background Fatigue is a common symptom in patients with advanced malignancy, and has been associated with both physiological and psychological factors in…”
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Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation by Dwyer, Karen M., Robson, Simon C., Nandurkar, Harshal H., Campbell, Duncan J., Gock, Hilton, Murray-Segal, Lisa J., Fisicaro, Nella, Mysore, Tharun B., Kaczmarek, Elzbieta, Cowan, Peter J., d’Apice, Anthony J.F.

“…Extracellular nucleotides play an important role in thrombosis and inflammation, triggering a range of effects such as platelet activation and recruitment,…”
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Out of sight, out of mind: an audit of inferior vena cava filter insertion and clinical follow up in an Australian institution and literature review by Tan, X. L., Tam, C., Mckellar, R., Nandurkar, H., Bazargan, A.

“…Background Inferior vena cava (IVC) filters are increasingly used to treat venous thromboembolism when there are contraindications or failure to respond to…”
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The SH2-Containing Inositol Polyphosphate 5-Phosphatase, SHIP-2, Binds Filamin and Regulates Submembraneous Actin by Dyson, Jennifer M., O'Malley, Cindy J., Becanovic, Jelena, Munday, Adam D., Berndt, Michael C., Coghill, Imogen D., Nandurkar, Harshal H., Ooms, Lisa M., Mitchell, Christina A.

“…SHIP-2 is a phosphoinositidylinositol 3,4,5 trisphosphate ( PtdIns[3,4,5] P3) 5-phosphatase that contains an NH2-terminal SH2 domain, a central 5-phosphatase…”
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Antiinflammatory and Anticoagulant Effects of Transgenic Expression of Human Thrombomodulin in Mice by Crikis, S., Zhang, X. M., Dezfouli, S., Dwyer, K. M., Murray‐Segal, L. M., Salvaris, E., Selan, C., Robson, S. C., Nandurkar, H. H., Cowan, P. J., D’Apice, A. J. F.

“…Thrombomodulin (TBM) is an important vascular anticoagulant that has species specific effects. When expressed as a transgene in pigs, human (h)TBM might…”
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The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation by Ooms, Lisa M, Fedele, Clare G, Astle, Megan V, Ivetac, Ivan, Cheung, Vanessa, Pearson, Richard B, Layton, Meredith J, Forrai, Ariel, Nandurkar, Harshal H, Mitchell, Christina A

“…The spatial activation of phosphoinositide 3-kinase (PI3-kinase) signaling at the axon growth cone generates phosphatidylinositol 3,4,5 trisphosphate…”
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Thrombocytopenia and Kidney Disease in Mice with a Mutation in the C1galt1 Gene by Alexander, Warren S., Viney, Elizabeth M., Zhang, Jian-Guo, Metcalf, Donald, Kauppi, Maria, Hyland, Craig D., Carpinelli, Marina R., Stevenson, William, Croker, Ben A., Hilton, Adrienne A., Ellis, Sarah, Selan, Carly, Nandurkar, Harshal H., Goodnow, Christopher C., Kile, Benjamin T., Nicola, Nicos A., Roberts, Andrew W., Hilton, Douglas J.

“…An N-ethyl-N-nitrosourea mutagenesis screen in mice was performed to isolate regulators of circulating platelet number. We report here recessive…”
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Identification of Myotubularin as the Lipid Phosphatase Catalytic Subunit Associated with the 3-Phosphatase Adapter Protein, 3-PAP by Nandurkar, Harshal H., Layton, Meredith, Laporte, Jocelyn, Selan, Carly, Corcoran, Lisa, Caldwell, Kevin K., Mochizuki, Yasuhiro, Majerus, Philip W., Mitchell, Christina A.

“…Myotubularin is a dual-specific phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bisphosphate. Mutations in…”
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