Search Results - "Nancy J. Sullivan"

Camouflage and Misdirection: The Full-On Assault of Ebola Virus Disease by Misasi, John, Sullivan, Nancy J.

“…Ebolaviruses cause a severe hemorrhagic fever syndrome that is rapidly fatal to humans and nonhuman primates. Ebola protein interactions with host cellular…”
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Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine by Wu, Kai, Werner, Anne P, Koch, Matthew, Choi, Angela, Narayanan, Elisabeth, Stewart-Jones, Guillaume B.E, Colpitts, Tonya, Bennett, Hamilton, Boyoglu-Barnum, Seyhan, Shi, Wei, Moliva, Juan I, Sullivan, Nancy J, Graham, Barney S, Carfi, Andrea, Corbett, Kizzmekia S, Seder, Robert A, Edwards, Darin K

“…How well do serum samples from persons vaccinated with the mRNA-1273 vaccine neutralize the P.1 lineage, the B.1.1.7 lineage, the B.1.1.7 lineage plus the…”
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Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529 by Zhou, Tongqing, Wang, Lingshu, Misasi, John, Pegu, Amarendra, Zhang, Yi, Harris, Darcy R, Olia, Adam S, Talana, Chloe Adrienna, Yang, Eun Sung, Chen, Man, Choe, Misook, Shi, Wei, Teng, I-Ting, Creanga, Adrian, Jenkins, Claudia, Leung, Kwanyee, Liu, Tracy, Stancofski, Erik-Stephane D, Stephens, Tyler, Zhang, Baoshan, Tsybovsky, Yaroslav, Graham, Barney S, Mascola, John R, Sullivan, Nancy J, Kwong, Peter D

“…The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (Omicron) variant and its resistance to neutralization by…”
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Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody by Corti, Davide, Misasi, John, Mulangu, Sabue, Stanley, Daphne A., Kanekiyo, Masaru, Wollen, Suzanne, Ploquin, Aurélie, Doria-Rose, Nicole A., Staupe, Ryan P., Bailey, Michael, Shi, Wei, Choe, Misook, Marcus, Hadar, Thompson, Emily A., Cagigi, Alberto, Silacci, Chiara, Fernandez-Rodriguez, Blanca, Perez, Laurent, Sallusto, Federica, Vanzetta, Fabrizia, Agatic, Gloria, Cameroni, Elisabetta, Kisalu, Neville, Gordon, Ingelise, Ledgerwood, Julie E., Mascola, John R., Graham, Barney S., Muyembe-Tamfun, Jean-Jacques, Trefry, John C., Lanzavecchia, Antonio, Sullivan, Nancy J.

“…Ebola virus disease in humans is highly lethal, with case fatality rates ranging from 25 to 90%. There is no licensed treatment or vaccine against the virus,…”
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Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake by Liang, Frank, Lindgren, Gustaf, Sandgren, Kerrie J, Thompson, Elizabeth A, Francica, Joseph R, Seubert, Anja, De Gregorio, Ennio, Barnett, Susan, O'Hagan, Derek T, Sullivan, Nancy J, Koup, Richard A, Seder, Robert A, Loré, Karin

“…The innate immune mechanisms by which adjuvants enhance the potency and protection of vaccine-induced adaptive immunity are largely unknown. We introduce a…”
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Structural and molecular basis for Ebola virus neutralization by protective human antibodies by Misasi, John, Gilman, Morgan S. A., Kanekiyo, Masaru, Gui, Miao, Cagigi, Alberto, Mulangu, Sabue, Corti, Davide, Ledgerwood, Julie E., Lanzavecchia, Antonio, Cunningham, James, Muyembe-Tamfun, Jean Jacques, Baxa, Ulrich, Graham, Barney S., Xiang, Ye, Sullivan, Nancy J., McLellan, Jason S.

“…Ebola virus causes hemorrhagic fever with a high case fatality rate for which there is no approved therapy. Two human monoclonal antibodies, mAb100 and mAb114,…”
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Correlates of protective immunity for Ebola vaccines: implications for regulatory approval by the animal rule by Sullivan, Nancy J, Martin, Julie E, Graham, Barney S, Nabel, Gary J

“…Key Points Ebola is a rare but deadly disease caused by a filovirus for which no treatment or vaccine is available. Vaccine development for such diseases is…”
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Ebolavirus Proteins Suppress the Effects of Small Interfering RNA by Direct Interaction with the Mammalian RNA Interference Pathway by FABOZZI, Giulia, NABEL, Christopher S, DOLAN, Michael A, SULLIVAN, Nancy J

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Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose-finding, phase 1/2a study by De Santis, Olga, MRes, Audran, Régine, PhD, Pothin, Emilie, PhD, Warpelin-Decrausaz, Loane, PhD, Vallotton, Laure, MD, Wuerzner, Grégoire, MD, Cochet, Camille, MD, Estoppey, Daniel, MD, Steiner-Monard, Viviane, MD, Lonchampt, Sophie, MSc, Thierry, Anne-Christine, BS, Mayor, Carole, BS, Bailer, Robert T, PhD, Mbaya, Olivier Tshiani, MD, Zhou, Yan, PhD, Ploquin, Aurélie, PhD, Sullivan, Nancy J, PhD, Graham, Barney S, MD, Roman, François, MD, De Ryck, Iris, MD, Ballou, W Ripley, MD, Kieny, Marie Paule, PhD, Moorthy, Vasee, MD, Spertini, François, MD, Genton, Blaise, Prof

“…Summary Background The ongoing Ebola outbreak led to accelerated efforts to test vaccine candidates. On the basis of a request by WHO, we aimed to assess the…”
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An introduction to the Marburg virus vaccine consortium, MARVAC by Cross, Robert W, Longini, Ira M, Becker, Stephan, Bok, Karin, Boucher, David, Carroll, Miles W, Díaz, Janet V, Dowling, William E, Draghia-Akli, Ruxandra, Duworko, James T, Dye, John M, Egan, Michael A, Fast, Patricia, Finan, Amy, Finch, Courtney, Fleming, Thomas R, Fusco, Joan, Geisbert, Thomas W, Griffiths, Anthony, Günther, Stephan, Hensley, Lisa E, Honko, Anna, Hunegnaw, Ruth, Jakubik, Jocelyn, Ledgerwood, Julie, Luhn, Kerstin, Matassov, Demetrius, Meshulam, Jeffrey, Nelson, Emily V, Parks, Christopher L, Rustomjee, Roxana, Safronetz, David, Schwartz, Lauren M, Smith, Dean, Smock, Paul, Sow, Ydrissa, Spiropoulou, Christina F, Sullivan, Nancy J, Warfield, Kelly L, Wolfe, Daniel, Woolsey, Courtney, Zahn, Roland, Henao-Restrepo, Ana María, Muñoz-Fontela, César, Marzi, Andrea

“…The emergence of Marburg virus (MARV) in Guinea and Ghana triggered the assembly of the MARV vaccine "MARVAC" consortium representing leaders in the field of…”
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Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection by Chandran, Kartik, Sullivan, Nancy J, Felbor, Ute, Whelan, Sean P, Cunningham, James M

“…Ebola virus (EboV) causes rapidly fatal hemorrhagic fever in humans and there is currently no effective treatment. We found that the infection of African green…”
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Recombinant Adenovirus Serotype 26 (Ad26) and Ad35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates against Ebolavirus Challenge by GEISBERT, Thomas W, BAILEY, Michael, CUSTERS, Jerome, VELLINGA, Jort, HENDRIKS, Jenny, JAHRLING, Peter, ROEDERER, Mario, GOUDSMIT, Jaap, KOUP, Richard, SULLIVAN, Nancy J, HENSLEY, Lisa, ASIEDU, Clement, GEISBERT, Joan, STANLEY, Daphne, HONKO, Anna, JOHNSON, Joshua, MULANGU, Sabue, GRAZIA PAU, Maria

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Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha through Omicron by Teng, I-Ting, Nazzari, Alexandra F, Choe, Misook, Liu, Tracy, Oliveira de Souza, Matheus, Petrova, Yuliya, Tsybovsky, Yaroslav, Wang, Shuishu, Zhang, Baoshan, Artamonov, Mykhaylo, Madan, Bharat, Huang, Aric, Lopez Acevedo, Sheila N, Pan, Xiaoli, Ruckwardt, Tracy J, DeKosky, Brandon J, Mascola, John R, Misasi, John, Sullivan, Nancy J, Zhou, Tongqing, Kwong, Peter D

“…Since the outbreak of the COVID-19 pandemic, widespread infections have allowed SARS-CoV-2 to evolve in human, leading to the emergence of multiple circulating…”
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Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, placebo-controlled clinical trial by Kibuuka, Hannah, MMed, Berkowitz, Nina M, MPH, Millard, Monica, MPH, Enama, Mary E, MA, Tindikahwa, Allan, MPH, Sekiziyivu, Arthur B, MSc, Costner, Pamela, BSN, Sitar, Sandra, MS, Glover, Deline, BS, Hu, Zonghui, PhD, Joshi, Gyan, MPH, Stanley, Daphne, MS, Kunchai, Meghan, MPH, Eller, Leigh Anne, PhD, Bailer, Robert T, PhD, Koup, Richard A, MD, Nabel, Gary J, MD, Mascola, John R, MD, Sullivan, Nancy J, PhD, Graham, Barney S, MD, Roederer, Mario, PhD, Michael, Nelson L, MD, Robb, Merlin L, MD, Ledgerwood, Julie E, Dr

“…Summary Background Ebola virus and Marburg virus cause serious disease outbreaks with high case fatality rates. We aimed to assess the safety and…”
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High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19 by Ko, Sung Hee, Bayat Mokhtari, Elham, Mudvari, Prakriti, Stein, Sydney, Stringham, Christopher D, Wagner, Danielle, Ramelli, Sabrina, Ramos-Benitez, Marcos J, Strich, Jeffrey R, Davey, Jr, Richard T, Zhou, Tongqing, Misasi, John, Kwong, Peter D, Chertow, Daniel S, Sullivan, Nancy J, Boritz, Eli A

“…Tracking evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within infected individuals will help elucidate coronavirus disease 2019…”
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Vaccine Generation of Protective Ebola Antibodies and Identification of Conserved B-Cell Signatures by Cagigi, Alberto, Misasi, John, Ploquin, Aurélie, Stanley, Daphne A, Ambrozak, David, Tsybovsky, Yaroslav, Mason, Rosemarie D, Roederer, Mario, Sullivan, Nancy J

“…We recently identified a single potently neutralizing monoclonal antibody (mAb), mAb114, isolated from a human survivor of natural Zaire ebolavirus (EBOV)…”
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Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys by Oswald, Wendelien B, Geisbert, Thomas W, Davis, Kelly J, Geisbert, Joan B, Sullivan, Nancy J, Jahrling, Peter B, Parren, Paul W H I, Burton, Dennis R

“…Prophylaxis with high doses of neutralizing antibody typically offers protection against challenge with viruses producing acute infections. In this study, we…”
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Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses by Feldmann, Heinz, Jones, Steven M, Ströher, Ute, Geisbert, Joan B, Fernando, Lisa, Grolla, Allen, Klenk, Hans-Dieter, Sullivan, Nancy J, Volchkov, Viktor E, Fritz, Elizabeth A, Daddario, Kathleen M, Hensley, Lisa E, Jahrling, Peter B, Geisbert, Thomas W

“…Vaccines and therapies are urgently needed to address public health needs stemming from emerging pathogens and biological threat agents such as the filoviruses…”
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Protection against Marburg Virus and Sudan Virus in NHP by an Adenovector-Based Trivalent Vaccine Regimen Is Correlated to Humoral Immune Response Levels by Tiemessen, Machteld M, Solforosi, Laura, Dekking, Liesbeth, Czapska-Casey, Dominika, Serroyen, Jan, Sullivan, Nancy J, Volkmann, Ariane, Pau, Maria Grazia, Callendret, Benoit, Schuitemaker, Hanneke, Luhn, Kerstin, Zahn, Roland, Roozendaal, Ramon

“…The Marburg virus (MARV) and Sudan virus (SUDV) belong to the filovirus family. The sporadic human outbreaks occur mostly in Africa and are characterized by an…”
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A new approach for monitoring ebolavirus in wild great apes by Reed, Patricia E, Mulangu, Sabue, Cameron, Kenneth N, Ondzie, Alain U, Joly, Damien, Bermejo, Magdalena, Rouquet, Pierre, Fabozzi, Giulia, Bailey, Michael, Shen, Zhimin, Keele, Brandon F, Hahn, Beatrice, Karesh, William B, Sullivan, Nancy J

“…Central Africa is a "hotspot" for emerging infectious diseases (EIDs) of global and local importance, and a current outbreak of ebolavirus is affecting…”
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