Search Results - "Nan, Yanyang"

Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis by Zhang, Xuyao, Luan, Jingyun, Chen, Wei, Fan, Jiajun, Nan, Yanyang, Wang, Yichen, Liang, Yanxu, Meng, Guangxun, Ju, Dianwen

“…Increased biomedical applications of mesoporous silica nanoparticles (MSNs) raise considerable attention concerning their toxicological effects; the toxicities…”
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Editorial: Combinational immunotherapy of cancer: novel targets, mechanisms, and strategies by Nan, Yanyang, Ju, Dianwen, Zhang, Xuyao

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Inhibition of autophagy potentiated the anti-tumor effects of VEGF and CD47 bispecific therapy in glioblastoma by Zhang, Xuyao, Wang, Shaofei, Nan, Yanyang, Fan, Jiajun, Chen, Wei, Luan, Jingyun, Wang, Yichen, Liang, Yanxu, Li, Song, Tian, Wenzhi, Ju, Dianwen

“…Glioblastoma, characterized by extensive microvascular proliferation and invasive tumor growth, is one of the most common and lethal malignancies in adults…”
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Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer by Xu, Caili, Huang, Xiting, Hu, Qinchao, Xue, Wenjing, Zhou, Kaicheng, Li, Xingxiu, Nan, Yanyang, Ju, Dianwen, Wang, Ziyu, Zhang, Xuyao

“…Pancreatic cancer, characterized by a dismal prognosis and limited treatment options, persists as a formidable challenge in oncology. Trophoblast cell surface…”
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Innate Immunity in Cancer Biology and Therapy by Zhang, Yuxia, Xue, Wenjing, Xu, Caili, Nan, Yanyang, Mei, Shuang, Ju, Dianwen, Wang, Shaofei, Zhang, Xuyao

“…Immunotherapies including adaptive immune checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR) T cells, have developed the treatment of cancer in…”
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Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation by Hu, Xiaozhi, Nan, Yanyang, Zhang, Yuting, Fan, Jiajun, Wang, Hanqi, Bai, Yu, Zhang, Yuanzhen, Zhang, Xuyao, Zhu, Zeguo, Cao, Zhonglian, Ye, Xiaomiao, Wu, Tao, Xu, Shuwen, Wu, Zhengyu, Hu, Wei, Ju, Dianwen

“…Atherosclerosis (AS) ultimately cause major adverse cardiovascular events (MACEs). While traditional strategies by lipid-reducing have reduced MACEs, many…”
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Inhibition of Hedgehog signaling ameliorates foam cell formation by promoting autophagy in early atherosclerosis by Zhang, Yuting, Xin, Weijuan, Hu, Xiaozhi, Wang, Hanqi, Ye, Xiaomiao, Xu, Caili, Nan, Yanyang, Wu, Zhengyu, Ju, Dianwen, Fan, Jiajun

“…Macrophages are the origin of most foam cells in the early stage of atherosclerotic plaques. However, the mechanism involved in the formation of…”
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Targeting 4-1BB and PD-L1 induces potent and durable antitumor immunity in B-cell lymphoma by Wang, Yichen, Zhang, Xuyao, Xu, Caili, Nan, Yanyang, Fan, Jiajun, Zeng, Xian, Kwon, Byoung S, Ju, Dianwen

“…Although PD-1/L1 mAb has demonstrated clinical benefits in certain cancer types, low response rate and resistance remain the main challenges for the…”
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A potential strategy for bladder cancer treatment: inhibiting autophagy to enhance antitumor effects of Nectin-4-MMAE by Wang, Yichen, Nan, Yanyang, Ma, Chunguang, Lu, Xiaolin, Wang, Qian, Huang, Xiting, Xue, Wenjing, Fan, Jiajun, Ju, Dianwen, Ye, Dingwei, Zhang, Xuyao

“…Research and development on Nectin-4 antibody-drug conjugates (ADC) have been greatly accelerated since the approval of enfortumab vedotin to treat…”
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Targeting CD47 and Angiogenesis Demonstrates Effective Anti-Tumor Effect in Bladder Cancer by Huang, Xiting, Wang, Qian, Nan, Yanyang, Zhang, Xuyao, Xu, Ke, Ju, Dianwen, Ding, Weihong

“…Although immunotherapy has shown potential in cancer treatment, current immunotherapeutics for bladder cancer are limited by a low response rate. Therefore, it…”
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A novel nanobody-heavy chain antibody against Angiopoietin-like protein 3 reduces plasma lipids and relieves nonalcoholic fatty liver disease by Hu, Xiaozhi, Fan, Jiajun, Ma, Qianqian, Han, Lei, Cao, Zhonglian, Xu, Caili, Luan, Jingyun, Jing, Guangjun, Nan, Yanyang, Wu, Tao, Zhang, Yuting, Wang, Hanqi, Zhang, Yuanzhen, Ju, Dianwen

“…Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease mainly on account of hypercholesterolemia and may progress to cirrhosis and hepatocellular…”
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A novel fusion protein consisting of anti-ANGPTL3 antibody and interleukin-22 ameliorates diabetic nephropathy in mice by Ma, Qianqian, Hu, Xiaozhi, Liu, Fangyu, Cao, Zhonglian, Han, Lei, Zhou, Kaicheng, Bai, Yu, Zhang, Yuting, Nan, Yanyang, Lv, Qianying, Rao, Jia, Wu, Tao, Yang, Xue, He, Haidong, Ju, Dianwen, Xu, Hong

“…The pathogenic mechanisms of diabetic nephropathy (DN) include podocyte injury, inflammatory responses and metabolic disorders. Although the antagonism of…”
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Enhancing antitumor efficacy of CLDN18.2-directed antibody-drug conjugates through autophagy inhibition in gastric cancer by Xue, Wenjing, Xu, Caili, Zhang, Kaiqi, Cui, Lu, Huang, Xiting, Nan, Yanyang, Ju, Dianwen, Chang, Xusheng, Zhang, Xuyao

“…Claudin18.2 (CLDN18.2) is overexpressed in cancers of the digestive system, rendering it an ideal drug target for antibody-drug conjugates (ADCs). Despite many…”
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A Novel Bifunctional Fusion Protein (Anti-IL-17A-sST2) Protects against Acute Liver Failure, Modulating the TLR4/MyD88 Pathway and NLRP3 Inflammasome Activation by Bai, Yu, Zhou, Rongrui, Xie, Xinlei, Zhu, An, Nan, Yanyang, Wu, Tao, Hu, Xiaozhi, Cao, Zhonglian, Ju, Dianwen, Fan, Jiajun

“…Acute liver failure (ALF) is a serious inflammatory disorder with high mortality rates, which poses a significant threat to human health. The IL-33/ST2 signal…”
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Lipid Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Against Rubicon Ameliorates NAFLD by Modulating CD36 Along with Glycerophospholipid Metabolism by Bai, Yu, Nan, Yanyang, Wu, Tao, Zhu, An, Xie, Xinlei, Sun, Yun, Deng, Yong, Dou, Zihan, Hu, Xiaozhi, Zhou, Rongrui, Xu, Shuwen, Zhang, Yuanzhen, Fan, Jiajun, Ju, Dianwen

“…Non‐alcoholic fatty liver disease (NAFLD) is a prominent cause of various chronic metabolic hepatic diseases with limited therapeutics. Rubicon, an essential…”
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Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy by Nan, Yanyang, Bai, Yu, Hu, Xiaozhi, Zhou, Kaicheng, Wu, Tao, Zhu, An, Li, Mengyang, Dou, Zihan, Cao, Zhonglian, Zhang, Xumeng, Xu, Shuwen, Zhang, Yuanzhen, Lin, Jun, Zeng, Xian, Fan, Jiajun, Zhang, Xuyao, Wang, Xuebin, Ju, Dianwen

“…BackgroundThe main challenge against patients with cancer to derive benefits from immune checkpoint inhibitors targeting PD-1/PD-L1 appears to be the…”
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Simultaneous blockade of VEGF-B and IL-17A ameliorated diabetic kidney disease by reducing ectopic lipid deposition and alleviating inflammation response by Cao, Zhonglian, Zhao, Hui, Fan, Jiajun, Shen, Yilan, Han, Lei, Jing, Guangjun, Zeng, Xian, Jin, Xin, Zhu, Zeguo, Bian, Qi, Nan, Yanyang, Hu, Xiaozhi, Mei, Xiaobin, Ju, Dianwen, Yang, Ping

“…The pathogenesis of diabetic kidney disease (DKD) is complicated. Current clinical treatments fail to achieve satisfactory efficacy in the prevention of DKD…”
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Activating Autophagy Enhanced the Antitumor Effect of Antibody Drug Conjugates Rituximab-Monomethyl Auristatin E by Wang, Yichen, Zhang, Xuyao, Fan, Jiajun, Chen, Wei, Luan, Jingyun, Nan, Yanyang, Wang, Shaofei, Chen, Qicheng, Zhang, Yujie, Wu, Youling, Ju, Dianwen

“…Antibody drug conjugate (ADC) showed potent therapeutic efficacy in several types of cancers. The role of autophagy in antitumor effects of ADC remains…”
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Characterization of light chain c-terminal extension sequence variant in one bispecific antibody by Lin, Jun, Xie, Mengyu, Liu, Dan, Gao, Zhen, Zhao, Xiaoyan, Ma, Hongxia, Ding, Sheng, Li, Shu mei, Li, Song, Liu, Yanling, Zhou, Fang, Hu, Hao, Chen, Tao, Chen, He, Xie, Min, Yang, Bo, Cheng, Jun, Ma, Mingjun, Nan, Yanyang, Ju, Dianwen

“…Protein modifications such as post-translational modifications (PTMs) and sequence variants (SVs) occur frequently during protein biosynthesis and have…”
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Discovery of novel hydroxyamidine derivatives as indoleamine 2,3-dioxygenase 1 inhibitors with in vivo anti-tumor efficacy by Liu, Chang, Nan, Yanyang, Xia, Zhifeng, Gu, Kedan, Chen, Cheng, Dong, Xiaochun, Ju, Dianwen, Zhao, Weili

“…[Display omitted] Indoleamine 2,3-dioxygenase 1 (IDO1) is closely associated with immune escape in many tumor tissues, and is considered to be a valuable…”
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