Search Results - "Namekawa, Satoshi"

Epigenetic priming in the male germline by Kitamura, Yuka, Namekawa, Satoshi H

“…Epigenetic priming presets chromatin states that allow the rapid induction of gene expression programs in response to differentiation cues. In the germline, it…”
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PRC1 directs PRC2-H3K27me3 deposition to shield adult spermatogonial stem cells from differentiation by Hu, Mengwen, Yeh, Yu-Han, Maezawa, So, Nakagawa, Toshinori, Yoshida, Shosei, Namekawa, Satoshi H

“…Abstract Spermatogonial stem cells functionality reside in the slow-cycling and heterogeneous undifferentiated spermatogonia cell population. This pool of…”
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Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin by Sakashita, Akihiko, Ooga, Masatoshi, Otsuka, Kai, Maezawa, So, Takeuchi, Chikara, Wakayama, Sayaka, Wakayama, Teruhiko, Namekawa, Satoshi H

“…Abstract Sperm chromatin retains small amounts of histones, and chromatin states of sperm mirror gene expression programs of the next generation. However, it…”
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Chromatin remodeler CHD8 is required for spermatogonial proliferation and early meiotic progression by Nitahara, Kenta, Kawamura, Atsuki, Kitamura, Yuka, Kato, Kiyoko, Namekawa, Satoshi H, Nishiyama, Masaaki

“…Meiosis is a key step during germ cell differentiation, accompanied by the activation of thousands of genes through germline-specific chromatin reorganization…”
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Dynamic reorganization of open chromatin underlies diverse transcriptomes during spermatogenesis by Maezawa, So, Yukawa, Masashi, Alavattam, Kris G, Barski, Artem, Namekawa, Satoshi H

“…Abstract During spermatogenesis, germ cells undergo massive cellular reconstruction and dynamic chromatin remodeling to facilitate highly diverse…”
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Cancer testis antigens and genomic instability: More than immunology by Jay, Ash, Reitz, Diedre, Namekawa, Satoshi H., Heyer, Wolf-Dietrich

“…Cancer testis antigens or genes (CTA, CTG) are predominantly expressed in adult testes while silenced in most or all somatic tissues with sporadic expression…”
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Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes by Yano, Seiichi, Ishiuchi, Takashi, Abe, Shusaku, Namekawa, Satoshi H., Huang, Gang, Ogawa, Yoshihiro, Sasaki, Hiroyuki

“…Establishment of the DNA methylation landscape of mammalian oocytes, mediated by the DNMT3A-DNMT3L complex, is crucial for reproduction and development. In…”
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CRISPR-Mediated Activation of Transposable Elements in Embryonic Stem Cells by Sakashita, Akihiko, Ariura, Masaru, Namekawa, Satoshi H

“…Mounting evidence has established that subsets of transposable elements (TEs) function as gene regulatory elements in a cell type- and species-specific manner…”
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MEK/ERK signaling directly and indirectly contributes to the cyclical self‐renewal of spermatogonial stem cells by Hasegawa, Kazuteru, Namekawa, Satoshi H., Saga, Yumiko

“…Coordination of stem cell fate is regulated by extrinsic niche signals and stem cell intrinsic factors. In mammalian testes, spermatogonial stem cells maintain…”
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Attenuated chromatin compartmentalization in meiosis and its maturation in sperm development by Alavattam, Kris G., Maezawa, So, Sakashita, Akihiko, Khoury, Haia, Barski, Artem, Kaplan, Noam, Namekawa, Satoshi H.

“…Germ cells manifest a unique gene expression program and regain totipotency in the zygote. Here, we perform Hi-C analysis to examine 3D chromatin organization…”
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Epigenetic programming in the ovarian reserve by Hu, Mengwen, Schultz, Richard M, Namekawa, Satoshi H

“…The ovarian reserve defines female reproductive lifespan, which in humans spans decades. The ovarian reserve consists of oocytes residing in primordial…”
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Meiotic sex chromosome inactivation and the XY body: a phase separation hypothesis by Alavattam, Kris G., Maezawa, So, Andreassen, Paul R., Namekawa, Satoshi H.

“…In mammalian male meiosis, the heterologous X and Y chromosomes remain unsynapsed and, as a result, are subject to meiotic sex chromosome inactivation (MSCI)…”
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UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells by Dong, Juan, Wang, Xiaoli, Cao, Congcong, Wen, Yujiao, Sakashita, Akihiko, Chen, Si, Zhang, Jin, Zhang, Yue, Zhou, Liquan, Luo, Mengcheng, Liu, Mingxi, Liao, Aihua, Namekawa, Satoshi H., Yuan, Shuiqiao

“…DNA methylation, repressive histone marks, and PIWI-interacting RNA (piRNA) are essential for the control of retrotransposon silencing in the mammalian…”
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SCML2 Establishes the Male Germline Epigenome through Regulation of Histone H2A Ubiquitination by Hasegawa, Kazuteru, Sin, Ho-Su, Maezawa, So, Broering, Tyler J., Kartashov, Andrey V., Alavattam, Kris G., Ichijima, Yosuke, Zhang, Fan, Bacon, W. Clark, Greis, Kenneth D., Andreassen, Paul R., Barski, Artem, Namekawa, Satoshi H.

“…Gametogenesis is dependent on the expression of germline-specific genes. However, it remains unknown how the germline epigenome is distinctly established from…”
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RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes by Adams, Shannel R, Maezawa, So, Alavattam, Kris G, Abe, Hironori, Sakashita, Akihiko, Shroder, Megan, Broering, Tyler J, Sroga Rios, Julie, Thomas, Michael A, Lin, Xinhua, Price, Carolyn M, Barski, Artem, Andreassen, Paul R, Namekawa, Satoshi H

“…The sex chromosomes are enriched with germline genes that are activated during the late stages of spermatogenesis. Due to meiotic sex chromosome inactivation…”
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Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition by Maezawa, So, Sakashita, Akihiko, Yukawa, Masashi, Chen, Xiaoting, Takahashi, Kazuki, Alavattam, Kris G., Nakata, Ippo, Weirauch, Matthew T., Barski, Artem, Namekawa, Satoshi H.

“…Owing to bursts in the expression of thousands of germline-specific genes, the testis has the most diverse and complex transcriptome of all organs. By…”
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Endogenous retroviruses drive species-specific germline transcriptomes in mammals by Sakashita, Akihiko, Maezawa, So, Takahashi, Kazuki, Alavattam, Kris G., Yukawa, Masashi, Hu, Yueh-Chiang, Kojima, Shohei, Parrish, Nicholas F., Barski, Artem, Pavlicev, Mihaela, Namekawa, Satoshi H.

“…Gene regulation in the germline ensures the production of high-quality gametes, long-term maintenance of the species and speciation. Male germline…”
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The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis by Abe, Hironori, Alavattam, Kris G., Hu, Yueh-Chiang, Pang, Qishen, Andreassen, Paul R., Hegde, Rashmi S., Namekawa, Satoshi H.

“…Meiotic sex chromosome inactivation (MSCI) is an essential event in the mammalian male germline. MSCI is directed by a DNA damage response (DDR) pathway…”
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ATAC-Seq Analysis of Accessible Chromatin: From Experimental Steps to Data Analysis by Tatara, Mayu, Ikeda, Taiyo, Namekawa, Satoshi H, Maezawa, So

“…Accessible chromatin often represents gene regulatory elements, including promoters and enhancers, essential for gene expression. Assay for Transposase…”
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Paternally inherited H3K27me3 affects chromatin accessibility in mouse embryos produced by round spermatid injection by Sakamoto, Mizuki, Ito, Daiyu, Inoue, Rei, Wakayama, Sayaka, Kikuchi, Yasuyuki, Yang, Li, Hayashi, Erika, Emura, Rina, Shiura, Hirosuke, Kohda, Takashi, Namekawa, Satoshi H., Ishiuchi, Takashi, Wakayama, Teruhiko, Ooga, Masatoshi

“…ABSTRACT Round spermatid injection (ROSI) results in a lower birth rate than intracytoplasmic sperm injection, which has hampered its clinical application…”
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