Search Results - "Namba, Hisaaki"

Post-pubertal Difference in Nigral Dopaminergic Cells Firing in the Schizophrenia Model Prepared by Perinatal Challenges of a Cytokine, EGF by Namba, Hisaaki, Nawa, Hiroyuki

“…•Physiological impact on nigral dopamine neurons of a schizophrenia model were evaluated before and after puberty.•In vivo burst firing was enhanced in…”
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The dual role of dopamine in the modulation of information processing in the prefrontal cortex underlying social behavior by Sotoyama, Hidekazu, Inaba, Hiroyoshi, Iwakura, Yuriko, Namba, Hisaaki, Takei, Nobuyuki, Sasaoka, Toshikuni, Nawa, Hiroyuki

“…Dopamine in the prefrontal cortex is essential for the regulation of social behavior. However, stress‐causing social withdrawal also promotes dopamine release…”
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Neonatal exposure to an inflammatory cytokine, epidermal growth factor, results in the deficits of mismatch negativity in rats by Jodo, Eiichi, Inaba, Hiroyoshi, Narihara, Itaru, Sotoyama, Hidekazu, Kitayama, Eiko, Yabe, Hirooki, Namba, Hisaaki, Eifuku, Satoshi, Nawa, Hiroyuki

“…Perinatal exposure to epidermal growth factor (EGF) induces various cognitive and behavioral abnormalities after maturation in non-human animals, and is used…”
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EL-1 Animal modeling of schizophrenia and its evaluation; use of auditory ERPs by Nawa, Hiroyuki, Narihara, Itaru, Sotoyama, Hidekazu, Namba, Hisaaki, Inaba, Hiroyoshi

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Schizophrenia Animal Modeling with Epidermal Growth Factor and Its Homologs: Their Connections to the Inflammatory Pathway and the Dopamine System by Sotoyama, Hidekazu, Namba, Hisaaki, Tohmi, Manavu, Nawa, Hiroyuki

“…Epidermal growth factor (EGF) and its homologs, such as neuregulins, bind to ErbB (Her) receptor kinases and regulate glial differentiation and…”
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Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia by Sotoyama, Hidekazu, Namba, Hisaaki, Kobayashi, Yutaro, Hasegawa, Taku, Watanabe, Dai, Nakatsukasa, Ena, Sakimura, Kenji, Furuyashiki, Tomoyuki, Nawa, Hiroyuki

“…Hyperdopaminergic activities are often linked to positive symptoms of schizophrenia, but their neuropathological implications on negative symptoms are rather…”
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Rat call-evoked electrocorticographic responses and intercortical phase synchrony impaired in a cytokine-induced animal model for schizophrenia by Narihara, Itaru, Kitajo, Keiichi, Namba, Hisaaki, Sotoyama, Hidekazu, Inaba, Hiroyoshi, Watanabe, Dai, Nawa, Hiroyuki

“…•The EGF-induced rat model for schizophrenia exhibited abnormal rat call-evoked electrocorticography.•The gamma power of rat call-evoked electrocorticography…”
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EGF Downregulates Presynaptic Maturation and Suppresses Synapse Formation In Vitro and In Vivo by Takei, Nobuyuki, Yokomaku, Daisaku, Yamada, Takaho, Nagano, Tadasato, Kakita, Akiyoshi, Namba, Hisaaki, Ushiki, Tatsuo, Takahashi, Hitoshi, Nawa, Hiroyuki

“…Neuronal differentiation, maturation, and synapse formation are regulated by various growth factors. Here we show that epidermal growth factor (EGF) negatively…”
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Increased self-triggered vocalizations in an epidermal growth factor-induced rat model for schizophrenia by Narihara, Itaru, Yokoyama, Hanako, Namba, Hisaaki, Sotoyama, Hidekazu, Inaba, Hiroyoshi, Kitayama, Eiko, Tamada, Kota, Takumi, Toru, Nawa, Hiroyuki

“…Rats elicit two types of ultrasonic vocalizations (USVs), positive (30–80 kHz; high pitch) and negative (10–30 kHz; low pitch) voices. As patients with…”
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Cerebrocortical activation following unilateral labyrinthectomy in mice characterized by whole-brain clearing: implications for sensory reweighting by Kai, Ryota, Takahashi, Kuniyuki, Tainaka, Kazuki, Iwakura, Yuriko, Namba, Hisaaki, Saito, Nae, Sasaoka, Toshikuni, Yamaguchi, Shun, Nawa, Hiroyuki, Horii, Arata

“…Posture and gait are maintained by sensory inputs from the vestibular, visual, and somatosensory systems and motor outputs. Upon vestibular damage, the visual…”
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Neuregulin-1 signals from the periphery regulate AMPA receptor sensitivity and expression in GABAergic interneurons in developing neocortex by Abe, Yuichi, Namba, Hisaaki, Kato, Taisuke, Iwakura, Yuriko, Nawa, Hiroyuki

“…Neuregulin-1 (NRG1) signaling is thought to contribute to both neuronal development and schizophrenia neuropathology. Here, we describe the developmental…”
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Perinatal Exposure to Neuregulin-1 Results in Disinhibition of Adult Midbrain Dopaminergic Neurons: Implication in Schizophrenia Modeling by Namba, Hisaaki, Okubo, Takeshi, Nawa, Hiroyuki

“…Aberrant neuregulin-1 (NRG1) signals are suggested to associate with the neuropathophysiology of schizophrenia. Employing a mouse schizophrenia model…”
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S25-1 Mismatch negativity and frequency spectra of electrocorticogram to duration deviance in a rat model of schizophrenia by Inaba, Hiroyoshi, Namba, Hisaaki, Sotoyama, Hidekazu, Narihara, Itaru, Jodo, Eiichi, Yabe, Hirooki, Eifuku, Satoshi, Nawa, Hiroyuki

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The dopamine D2 agonist quinpirole impairs frontal mismatch responses to sound frequency deviations in freely moving rats by Inaba, Hiroyoshi, Namba, Hisaaki, Kida, Satoshi, Nawa, Hiroyuki

“…Aim A reduced mismatch negativity (MMN) response is a promising electrophysiological endophenotype of schizophrenia that reflects neurocognitive impairment…”
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Excitatory connections of nonspiking interneurones in the terminal abdominal ganglion of the crayfish by Namba, Hisaaki, Nagayama, Toshiki

“…The output effects of the nonspiking interneurones in the crayfish terminal abdominal ganglion upon the uropod motor neurones were characterized using…”
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Brain-Derived Neurotrophic Factor Induces Mammalian Target of Rapamycin-Dependent Local Activation of Translation Machinery and Protein Synthesis in Neuronal Dendrites by Takei, Nobuyuki, Inamura, Naoko, Kawamura, Mihoko, Namba, Hisaaki, Hara, Kenta, Yonezawa, Kazuyoshi, Nawa, Hiroyuki

“…In neurons, perisynaptic or dendritic translation is implicated in synapse-wide alterations of function and morphology triggered by neural activity. The…”
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Epidermal growth factor signals attenuate phenotypic and functional development of neocortical GABA neurons by Namba, Hisaaki, Nagano, Tadasato, Jodo, Eiichi, Eifuku, Satoshi, Horie, Masao, Takebayashi, Hirohide, Iwakura, Yuriko, Sotoyama, Hidekazu, Takei, Nobuyuki, Nawa, Hiroyuki

“…Phenotypic development of neocortical GABA neurons is highly plastic and promoted by various neurotrophic factors such as neuregulin‐1. A subpopulation of GABA…”
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Inter‐breeder differences in prepulse inhibition deficits of C57BL/6J mice in a maternal immune activation model by Kobayashi, Yutaro, Inaba, Hiroyoshi, Iwakura, Yuriko, Namba, Hisaaki, Sotoyama, Hidekazu, Murata, Yui, Iwamoto, Kazuya, Nawa, Hiroyuki

“…Genetic and environmental factors interact with each other to influence the risk of various psychiatric diseases; however, the intensity and nature of their…”
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Exposure to the cytokine EGF leads to abnormal hyperactivity of pallidal GABA neurons: implications for schizophrenia and its modeling by Sotoyama, Hidekazu, Namba, Hisaaki, Chiken, Satomi, Nambu, Atsushi, Nawa, Hiroyuki

“…Previous studies on a cytokine model for schizophrenia reveal that the hyperdopaminergic innervation and neurotransmission in the globus pallidus (GP) is…”
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Brain-derived Neurotrophic Factor Enhances the Basal Rate of Protein Synthesis by Increasing Active Eukaryotic Elongation Factor 2 Levels and Promoting Translation Elongation in Cortical Neurons by Takei, Nobuyuki, Kawamura, Mihoko, Ishizuka, Yuta, Kakiya, Naomasa, Inamura, Naoko, Namba, Hisaaki, Nawa, Hiroyuki

“…The constitutive and activity-dependent components of protein synthesis are both critical for neural function. Although the mechanisms controlling…”
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