Search Results - "Namazzi, Ruth"
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Xanthine oxidase levels and immune dysregulation are independently associated with anemia in Plasmodium falciparum malaria
Published in Scientific reports (07-09-2023)“…Severe anemia is an important contributor to mortality in children with severe malaria. Anemia in malaria is a multi-factorial complication, since…”
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Intestinal Injury Biomarkers Predict Mortality in Pediatric Severe Malaria
Published in mBio (26-10-2022)“…Severe malaria (SM) increases the risk of invasive bacterial infection, and there is evidence to suggest increased gastrointestinal permeability. Studies have…”
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Outcomes of pediatric in-hospital cardiac arrest in the emergency department of a tertiary referral hospital in Tanzania: a retrospective cohort study
Published in BMC emergency medicine (03-10-2024)“…Cardiopulmonary resuscitation (CPR) is an emergency procedure performed to restore heart function to minimize anoxic injury to the brain following cardiac…”
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4
Parenteral artemisinins are associated with reduced mortality and neurologic deficits and improved long-term behavioral outcomes in children with severe malaria
Published in BMC medicine (28-07-2021)“…In 2011, the World Health Organization recommended injectable artesunate as the first-line therapy for severe malaria (SM) due to its superiority in reducing…”
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The Ugandan sickle Pan-African research consortium registry: design, development, and lessons
Published in BMC medical informatics and decision making (29-07-2024)“…Sub-Saharan Africa bears the highest burden of sickle cell disease (SCD) globally with Nigeria, Democratic Republic of Congo, Tanzania, Uganda being the most…”
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Acute kidney injury, persistent kidney disease, and post-discharge morbidity and mortality in severe malaria in children: A prospective cohort study
Published in EClinicalMedicine (01-02-2022)“…Globally, 85% of acute kidney injury (AKI) cases occur in low-and-middle-income countries. There is limited information on persistent kidney disease (acute…”
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Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: a prospective cohort study
Published in BMC nephrology (29-09-2020)“…Acute kidney injury (AKI) is increasingly recognized as a consequential clinical complication in children with severe malaria. However, approaches to estimate…”
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Rapid gene fusion testing using the NanoString nCounter platform to improve pediatric leukemia diagnoses in Sub-Saharan Africa
Published in Frontiers in oncology (13-06-2024)“…Risk stratification and molecular targeting have been key to increasing cure rates for pediatric cancers in high-income countries. In contrast, precise…”
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Evaluating kidney function using a point-of-care creatinine test in Ugandan children with severe malaria: a prospective cohort study
Published in BMC nephrology (06-11-2021)“…Acute kidney injury (AKI) disproportionately affects individuals in low-and middle-income countries (LMIC). However, LMIC-particularly countries in sub-Saharan…”
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10
Orbital compression syndrome in a Ugandan child with sickle cell disease: A case report
Published in Clinical case reports (01-09-2021)“…Orbital compression syndrome is a rare acute complication of sickle cell disease that may impair vision. Assessment by a multidisciplinary team incorporates…”
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Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): study protocol for a randomized placebo-controlled trial in Ugandan children with sickle cell anemia
Published in Current controlled trials in cardiovascular medicine (26-07-2019)“…Sickle cell anemia (SCA) is the most common inherited hemoglobinopathy worldwide. Infection is a major cause of illness and death in children with SCA,…”
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Renin as a Biomarker of Acute Kidney Injury and Mortality in Children With Severe Malaria or Sickle Cell Disease
Published in Curēus (Palo Alto, CA) (12-09-2023)“…Globally, a very high percentage of acute kidney injury (AKI) occurs in low- and middle-income countries (LMICs) where late recognition contributes to…”
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Development of research capacity in sickle cell anemia in Uganda: impact of collaborations
Published in Blood advances (08-12-2017)Get full text
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Azithromycin for Prevention of Mortality in African ChildrenMore Data, More Questions
Published in JAMA : the journal of the American Medical Association (13-02-2024)“…Mass administration of oral azithromycin has been shown to reduce mortality in African children, but questions remain regarding its efficacy and potential…”
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Elevated levels of PDGF-BB and VEGF are associated with a decreased risk of readmission or death in children with severe malarial anemia
Published in The Journal of infectious diseases (25-10-2024)“…Children with severe malarial anemia (SMA) typically have low in-hospital mortality but have a high risk of post-discharge readmission or death. We…”
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Azithromycin for Prevention of Mortality in African Children: More Data, More Questions
Published in JAMA : the journal of the American Medical Association (13-02-2024)Get full text
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sTREM-1: A Biomarker of Mortality in Severe Malaria Impacted by Acute Kidney Injury
Published in The Journal of infectious diseases (12-04-2024)“…Abstract Background Malaria is an important cause of mortality in African children. Identification of biomarkers to identify children at risk of mortality has…”
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Safe and Effective Escalation of Evidence-Based Chemotherapy for Mature B Cell Non-Hodgkin's Lymphoma in a Low Resource Setting
Published in Blood (02-11-2023)“…BACKGROUND Although high intensity chemotherapy regimens result in >90% long term survival of children with Mature B-cell Non-Hodgkin Lymphoma (MB-NHL), low…”
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Feasibility of a Dose-Intensive Regimen for Pediatric Burkitt Lymphoma in Malawi
Published in Blood (02-11-2023)“…Introduction: Burkitt lymphoma (BL) is the commonest childhood cancer diagnosed in Sub-Saharan Africa (SSA). It is highly curable with survival rates >90% in…”
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Impact of a National Lockdown for COVID-19 on Morbidity and Mortality Among Children with Sickle Cell Anaemia at a Tertiary Care Hospital in Uganda
Published in Blood (05-11-2020)“…COVID-19 and its prevention has put considerable strain on health care systems in low and middle-income countries (LMIC). In Uganda, a national lockdown was…”
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