Search Results - "Nam Soo Joo"

Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis by Choi, Jae Young, Joo, Nam Soo, Krouse, Mauri E, Wu, Jin V, Robbins, Robert C, Ianowski, Juan P, Hanrahan, John W, Wine, Jeffrey J

“…Cystic fibrosis (CF) is caused by dysfunction of the CF transmembrane conductance regulator (CFTR), an anion channel whose dysfunction leads to chronic…”
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Hyposecretion, Not Hyperabsorption, Is the Basic Defect of Cystic Fibrosis Airway Glands by Joo, Nam Soo, Irokawa, Toshiya, Robbins, Robert C., Wine, Jeffrey J.

“…Human airways and glands express the anion channel cystic fibrosis transmembrane conductance regulator, CFTR, and the epithelial Na+ channel, ENaC. Cystic…”
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Acid and base secretion in the Calu-3 model of human serous cells by Krouse, Mauri E, Talbott, Jason F, Lee, Martin M, Joo, Nam Soo, Wine, Jeffrey J

“…Submucosal glands are the primary source of airway mucus, a critical component of lung innate defenses. Airway glands are defective in cystic fibrosis (CF),…”
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Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis by Sun, Xingshen, Sui, Hongshu, Fisher, John T, Yan, Ziying, Liu, Xiaoming, Cho, Hyung-Ju, Joo, Nam Soo, Zhang, Yulong, Zhou, Weihong, Yi, Yaling, Kinyon, Joann M, Lei-Butters, Diana C, Griffin, Michelle A, Naumann, Paul, Luo, Meihui, Ascher, Jill, Wang, Kai, Frana, Timothy, Wine, Jeffrey J, Meyerholz, David K, Engelhardt, John F

“…Cystic fibrosis (CF) is a recessive disease that affects multiple organs. It is caused by mutations in CFTR. Animal modeling of this disease has been…”
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Variation in CFTR-dependent 'β-sweating' among healthy adults by DeRose, Lesje, Kim, Jeeyeon, Farahmand, Miesha, Shinbashi, Meagan Y, Joo, Nam Soo, Wine, Jeffrey J

“…The genetic disease cystic fibrosis (CF) results when mutations in the gene for the anion channel CFTR reduce CFTR's activity below a critical level. CFTR…”
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Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigs by Joo, Nam Soo, Cho, Hyung-Ju, Khansaheb, Monal, Wine, Jeffrey J

“…Cystic fibrosis (CF) results from mutations that disrupt CF transmembrane conductance regulator (CFTR), an anion channel found mainly in apical membranes of…”
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Combined agonists act synergistically to increase mucociliary clearance in a cystic fibrosis airway model by Joo, Nam Soo, Cho, Hyung-Ju, Shinbashi, Meagan, Choi, Jae Young, Milla, Carlos E., Engelhardt, John F., Wine, Jeffrey J.

“…Mucus clearance, a primary innate defense mechanism of airways, is defective in patients with cystic fibrosis (CF) and CF animals. In previous work, the…”
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Proteomic analysis of pure human airway gland mucus reveals a large component of protective proteins by Joo, Nam Soo, Evans, Idil Apak T, Cho, Hyung-Ju, Park, Il-Ho, Engelhardt, John F, Wine, Jeffrey J

“…Airway submucosal glands contribute to innate immunity and protect the lungs by secreting mucus, which is required for mucociliary clearance and which also…”
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An Inwardly Rectifying Potassium Channel in Apical Membrane of Calu-3 Cells by Wu, Jin V, Krouse, Mauri E, Rustagi, Arjun, Joo, Nam Soo, Wine, Jeffrey J

“…Patch clamp methods and reverse transcription-polymerase chain reaction (RT-PCR) were used to characterize an apical K + channel in Calu-3 cells, a widely used…”
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Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process by Choi, Jae Young, Khansaheb, Monal, Joo, Nam Soo, Krouse, Mauri E, Robbins, Robert C, Weill, David, Wine, Jeffrey J

“…Chronic bacterial airway infections are the major cause of mortality in cystic fibrosis (CF). Normal airway defenses include reflex stimulation of submucosal…”
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In vivo readout of CFTR function: ratiometric measurement of CFTR-dependent secretion by individual, identifiable human sweat glands by Wine, Jeffrey J, Char, Jessica E, Chen, Jonathan, Cho, Hyung-Ju, Dunn, Colleen, Frisbee, Eric, Joo, Nam Soo, Milla, Carlos, Modlin, Sara E, Park, Il-Ho, Thomas, Ewart A C, Tran, Kim V, Verma, Rohan, Wolfe, Marlene H

“…To assess CFTR function in vivo, we developed a bioassay that monitors and compares CFTR-dependent and CFTR-independent sweat secretion in parallel for…”
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Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease by Sellers, Zachary M, Illek, Beate, Figueira, Miriam Frankenthal, Hari, Gopika, Joo, Nam Soo, Sibley, Eric, Souza-Menezes, Jackson, Morales, Marcelo M, Fischer, Horst, Wine, Jeffrey J

“…Airway mucociliary clearance (MCC) is an important defense mechanism against pulmonary infections and is compromised in cystic fibrosis (CF). Cl- and HCO3-…”
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Mucus secretion from individual submucosal glands of the ferret trachea by Cho, Hyung-Ju, Joo, Nam Soo, Wine, Jeffrey J

“…Mucus secretion from individual tracheal glands in adult ferrets was studied with time-lapse optical imaging of mucus droplets under an oil layer. Density of…”
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Submucosal Gland Secretions in Airways from Cystic Fibrosis Patients Have Normal [Na+]and pH but Elevated Viscosity by Jayaraman, Sujatha, Joo, Nam Soo, Reitz, Bruce, Wine, Jeffrey J., Verkman, A. S.

“…Fluid and macromolecule secretion by submucosal glands in mammalian airways is believed to be important in normal airway physiology and in the pathophysiology…”
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Absent Secretion to Vasoactive Intestinal Peptide in Cystic Fibrosis Airway Glands by Joo, Nam Soo, Irokawa, Toshiya, Wu, Jin V., Robbins, Robert C., Whyte, Richard I., Wine, Jeffrey J.

“…We are testing the hypothesis that the malfunctioning of airway gland serous cells is a component of cystic fibrosis (CF) airway disease. CF is caused by…”
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QUEST FOR CYSTIC FIBROSIS PHARMACOTHERAPY by Soo Joo, Nam

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Regulation of Antiprotease and Antimicrobial Protein Secretion by Airway Submucosal Gland Serous Cells by Joo, Nam Soo, Lee, Dennis J., Winges, Kimberly M., Rustagi, Arjun, Wine, Jeffrey J.

“…Airway submucosal gland serous cells express the cystic fibrosis transmembrane conductance regulator (CFTR) and secrete antimicrobial, anti-inflammatory, and…”
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Optical method for quantifying rates of mucus secretion from single submucosal glands by Joo, N S, Wu, J V, Krouse, M E, Saenz, Y, Wine, J J

“…We describe an optical method to quantify single- gland secretion. Isolated tracheal mucosa were mounted at the air-Krebs interface and coated with oil. Gland…”
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A "virtual gland" method for quantifying epithelial fluid secretion by Irokawa, Toshiya, Krouse, Mauri E, Joo, Nam Soo, Wu, Jin V, Wine, Jeffrey J

“…We developed a new apparatus, the virtual gland (VG), for measuring the rate of fluid secretion (Jv), its composition, and the transepithelial potential (TEP)…”
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Defective fluid secretion from submucosal glands of nasal turbinates from CFTR-/- and CFTR (ΔF508/ΔF508) pigs by Cho, Hyung-Ju, Joo, Nam Soo, Wine, Jeffrey J

“…Cystic fibrosis (CF), caused by reduced CFTR function, includes severe sinonasal disease which may predispose to lung disease. Newly developed CF pigs provide…”
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