Search Results - "Nam, Yunsun"

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases by Wang, Ping, Doxtader, Katelyn A., Nam, Yunsun

“…N6-methyladenosine (m6A) is a prevalent, reversible chemical modification of functional RNAs and is important for central events in biology. The core m6A…”
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METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis by Su, Rui, Dong, Lei, Li, Yangchan, Gao, Min, He, P. Cody, Liu, Wei, Wei, Jiangbo, Zhao, Zhicong, Gao, Lei, Han, Li, Deng, Xiaolan, Li, Chenying, Prince, Emily, Tan, Brandon, Qing, Ying, Qin, Xi, Shen, Chao, Xue, Meilin, Zhou, Keren, Chen, Zhenhua, Xue, Jianhuang, Li, Wei, Qin, Hanjun, Wu, Xiwei, Sun, Miao, Nam, Yunsun, Chen, Chun-Wei, Huang, Wendong, Horne, David, Rosen, Steven T., He, Chuan, Chen, Jianjun

“…METTL16 has recently been identified as an RNA methyltransferase responsible for the deposition of N 6 -methyladenosine (m 6 A) in a few transcripts. Whether…”
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Structure of a complex of the ATPase SecA and the protein-translocation channel by Rapoport, Tom A, Zimmer, Jochen, Nam, Yunsun

“…Most proteins are secreted from bacteria by the interaction of the cytoplasmic SecA ATPase with a membrane channel, formed by the heterotrimeric SecY complex…”
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RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis by Ngo, Tri D., Partin, Alexander C., Nam, Yunsun

“…DDX17, a DEAD-box ATPase, is a multifunctional helicase important for various RNA functions, including microRNA maturation. Key questions for DDX17 include how…”
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Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs by Partin, Alexander C., Ngo, Tri D., Herrell, Emily, Jeong, Byung-Cheon, Hon, Gary, Nam, Yunsun

“…MicroRNAs regulate the expression of many proteins and require specific maturation steps. Primary microRNA transcripts (pri-miRs) are cleaved by…”
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LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation by Wang, Longfei, Nam, Yunsun, Lee, Anna K., Yu, Chunxiao, Roth, Kira, Chen, Casandra, Ransey, Elizabeth M., Sliz, Piotr

“…LIN28 is an RNA binding protein that plays crucial roles in pluripotency, glucose metabolism, tissue regeneration, and tumorigenesis. LIN28 binds to the let-7…”
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Structural Basis for Cooperativity in Recruitment of MAML Coactivators to Notch Transcription Complexes by Nam, Yunsun, Sliz, Piotr, Song, Luyan, Aster, Jon C., Blacklow, Stephen C.

“…Notch receptors transduce essential developmental signals between neighboring cells by forming a complex that leads to transcription of target genes upon…”
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Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription by Nam, Yunsun, Sliz, Piotr, Pear, Warren S, Aster, Jon C, Blacklow, Stephen C

“…Notch receptors control differentiation and contribute to pathologic states such as cancer by interacting directly with a transcription factor called CSL (for…”
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Publisher Correction: Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs by Partin, Alexander C., Ngo, Tri D., Herrell, Emily, Jeong, Byung-Cheon, Hon, Gary, Nam, Yunsun

“…The original version of this Article contained an error in Fig. 1. In panel d, the model on the right of the panel was incorrectly labeled ‘+Heme’, and should…”
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HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing by Liu, Haoming, Liang, Chunyang, Kollipara, Rahul K., Matsui, Masayuki, Ke, Xiong, Jeong, Byung-Cheon, Wang, Zhiqiang, Yoo, Kyoung Shin, Yadav, Gaya P., Kinch, Lisa N., Grishin, Nicholas V., Nam, Yunsun, Corey, David R., Kittler, Ralf, Liu, Qinghua

“…Recent studies suggest that the microprocessor (Drosha-DGCR8) complex can be recruited to chromatin to catalyze co-transcriptional processing of primary…”
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A role for the two-helix finger of the SecA ATPase in protein translocation by Rapoport, Tom A, Miller, Stephanie B. M, Osborne, Andrew R, Erlandson, Karl J, Nam, Yunsun, Zimmer, Jochen

“…An important step in the biosynthesis of many proteins is their partial or complete translocation across the plasma membrane in prokaryotes or the endoplasmic…”
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Structural Requirements for Assembly of the CSL·Intracellular Notch1·Mastermind-like 1 Transcriptional Activation Complex by Nam, Yunsun, Weng, Andrew P., Aster, Jon C., Blacklow, Stephen C.

“…Ligand binding by Notch receptors triggers a series of proteolytic cleavages that liberate the intracellular portion of Notch (ICN) from the cell membrane,…”
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Growth Suppression of Pre-T Acute Lymphoblastic Leukemia Cells by Inhibition of Notch Signaling by Weng, Andrew P., Nam, Yunsun, Wolfe, Michael S., Pear, Warren S., Griffin, James D., Blacklow, Stephen C., Aster, Jon C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification of a Conserved Negative Regulatory Sequence That Influences the Leukemogenic Activity of NOTCH1 by Chiang, Mark Y., Xu, Mina L., Histen, Gavin, Shestova, Olga, Roy, Monideepa, Nam, Yunsun, Blacklow, Stephen C., Sacks, David B., Pear, Warren S., Aster, Jon C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation by Aster, Jon C, Bodnar, Nick, Xu, Lanwei, Karnell, Fredrick, Milholland, John M, Maillard, Ivan, Histen, Gavin, Nam, Yunsun, Blacklow, Stephen C, Pear, Warren S

“…The functional interchangeability of mammalian Notch receptors (Notch1-4) in normal and pathophysiologic contexts such as cancer is unsettled. We used…”
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Dynamic Protein-RNA recognition in primary MicroRNA processing by Ruiz-Arroyo, Victor M, Nam, Yunsun

“…MicroRNAs are prevalent regulators of gene expression, controlling most of the proteome in multicellular organisms. To generate the functional small RNAs,…”
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Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor by Doxtader, Katelyn A., Wang, Ping, Scarborough, Anna M., Seo, Dahee, Conrad, Nicholas K., Nam, Yunsun

“…S-adenosylmethionine (SAM) is an essential metabolite that acts as a cofactor for most methylation events in the cell. The N6-methyladenosine (m6A)…”
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Structures and mechanisms of tRNA methylation by METTL1–WDR4 by Ruiz-Arroyo, Victor M., Raj, Rishi, Babu, Kesavan, Onolbaatar, Otgonbileg, Roberts, Paul H., Nam, Yunsun

“…Specific, regulated modification of RNAs is important for proper gene expression 1 , 2 . tRNAs are rich with various chemical modifications that affect their…”
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The m-step competition graph of a digraph by Cho, Han Hyuk, Kim, Suh-Ryung, Nam, Yunsun

“…The competition graph of a digraph was introduced by Cohen in 1968 associated with the study of ecosystems. Since then, the competition graph has been widely…”
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Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA by Partin, Alexander C., Zhang, Kaiming, Jeong, Byung-Cheon, Herrell, Emily, Li, Shanshan, Chiu, Wah, Nam, Yunsun

“…Metazoan microRNAs require specific maturation steps initiated by Microprocessor, comprising Drosha and DGCR8. Lack of structural information for the assembled…”
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