Prognostic impact of EGFR mutation in non-small-cell lung cancer patients with family history of lung cancer

A family history can be a valuable tool in the era of precision medicine. Although a few studies have described an association of family history of lung cancer with EGFR activating mutation, their impact on survival of lung cancer patients is unclear. The study included consecutive 829 non-small-cel...

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Bibliographic Details
Published in:	PloS one Vol. 12; no. 5; p. e0177015
Main Authors:	Kim, Jung Soo, Cho, Min Seong, Nam, Jong Hyeon, Kim, Hyun-Jung, Choi, Kyeng-Won, Ryu, Jeong-Seon
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 09-05-2017 Public Library of Science (PLoS)
Subjects:	Age Agglomeration Amplification Biology and Life Sciences Body mass Body mass index Cancer Cancer therapies Carcinoma, Non-Small-Cell Lung - genetics Cell death Chains (polymeric) Chemotherapy Classification Clonal deletion Computer programs Confidence intervals Cytotoxicity Deoxyribonucleic acid Diagnosis DNA DNA sequencing Effusion Epidermal growth factor Epidermal growth factor receptors Exons Family medical history Fragmentation Fragments Genetic diversity Genetic Predisposition to Disease Genetics Health risks Histology Hospitals Immunotherapy Impact prediction Inhibitors Internal medicine Lung cancer Lung cancer, Non-small cell Lung diseases Lung Neoplasms - genetics Medical diagnosis Medical prognosis Medical research Medicine Medicine and Health Sciences Metastases Mortality Mutation Offspring Oncology Patients Polymerase chain reaction Population studies Precision medicine Prognosis Radiation Radiation therapy Receptor, Epidermal Growth Factor - genetics Regression analysis Risk Smoking Statistical analysis Statistical methods Statistics Studies Survival Thorax Tumors
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Summary:	A family history can be a valuable tool in the era of precision medicine. Although a few studies have described an association of family history of lung cancer with EGFR activating mutation, their impact on survival of lung cancer patients is unclear. The study included consecutive 829 non-small-cell lung cancer patients who received analysis of EGFR mutation in a prospective lung cancer cohort. Family history of lung cancer was obtained by face-to-face interviews at the time of diagnosis. An association of EGFR activating mutation with a family history of lung cancer in first-degree relatives was evaluated with multivariate logistic regression analysis, and its association with survival was estimated with Cox's proportional hazards model. Seventy five (9.0%) patients had family history of lung cancer. The EGFR mutation was commonly observed in patients with positive family history compared to those with no family history (46.7% v 31.3%, χ2 p = 0.007). The family history was significantly associated with the EGFR mutation (aOR and 95% CI: 2.01 and 1.18-3.60, p = 0.011). Patients with the positive family history survived longer compared to those without (MST, 17.9 v 13.0 months, log-rank p = 0.037). The presence of the EGFR mutation was associated with better survival in patients without the family history (aHR and 95% CI: 0.72 and 0.57-0.90, p = 0.005). However, this prognostic impact was not observed in patients with the positive family history (aHR and 95% CI: 1.01 and 0.50-2.36, p = 0.832). In comparison to patients without the family history, EGFR activating mutation was common, and it did not affect prognosis in patients with positive family history.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceptualization: JSR.Data curation: HJK KWC MSC JHN.Formal analysis: HJK JSK.Funding acquisition: JSR.Investigation: JSK JSR.Methodology: JSK JSR.Project administration: JSK JSR HJK.Resources: HJK.Supervision: JSR HJK.Visualization: JSR KWC.Writing – original draft: JSK JSR.Writing – review & editing: JSK JSR MSC JHN.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0177015