Search Results - "Nam, David"
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Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection
Published in Neuron (Cambridge, Mass.) (05-06-2019)“…Neuronal and synaptic loss is characteristic in many neurodegenerative diseases, such as frontotemporal dementia and Alzheimer’s disease. Recently, we showed…”
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Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition
Published in Cell (04-04-2019)“…We previously reported that inducing gamma oscillations with a non-invasive light flicker (gamma entrainment using sensory stimulus or GENUS) impacted…”
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Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells
Published in Cancer cell (08-06-2020)“…Generation of tumor-infiltrating lymphocytes begins when tumor antigens reach the lymph node (LN) to stimulate T cells, yet we know little of how tumor…”
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Short Symptom Duration Is Associated With Superior Outcomes in Patients Undergoing Primary Hip Arthroscopy: A Systematic Review
Published in Arthroscopy (01-02-2023)“…To evaluate the effect of duration of preoperative hip pain symptoms on outcomes in patients undergoing primary hip arthroscopy for the treatment of…”
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Factors affecting outcomes of second intent healing of nasal defects after Mohs micrographic surgery
Published in Archives of dermatological research (01-01-2023)“…Reconstruction of nasal defects secondary to Mohs micrographic surgery (MMS) presents particular challenges related to the complex topography, skin quality,…”
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Preresidency Publication Productivity of U.S. Neurosurgery Interns
Published in World neurosurgery (01-05-2020)“…Research experience is believed to be an important component of the neurosurgery residency application process. One measure of research productivity is…”
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Mid- to Long-Term Outcomes in Patients After Hip Arthroscopy With Labral Reconstruction: A Systematic Review
Published in Orthopaedic Journal of Sports Medicine (01-06-2024)“…Background: There is a paucity of aggregate data documenting mid- to long-term outcomes of patients after hip arthroscopy with labral reconstruction. Purpose:…”
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A Popularity Contest? Exploring Predictors of Faculty Influence in Criminology and Criminal Justice
Published in Journal of criminal justice education (01-10-2024)“…Our study analyzes the factors associated with the faculty influence. We explore Google Scholar citation counts of 226 faculty at the top 20 doctoral programs…”
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Patients Undergoing Primary Hip Arthroscopy Report Favorable Outcomes at Minimum 10 Year Follow-Up: A Systematic Review
Published in Arthroscopy (01-02-2023)“…(1) To evaluate minimum 10-year PROs (patient-reported outcomes) and survivorship after primary hip arthroscopy and (2) to identify predictors of failure for…”
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Analysis of the Frequency, Characteristics, and Reasons for Termination of Spine-related Clinical Trials
Published in Clinical spine surgery (01-08-2022)“…Cross-sectional analysis of completed and terminated spine-related clinical trials in the ClinicalTrials.gov registry. The aim was to quantify completed and…”
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Artificial intelligence in liver diseases: Improving diagnostics, prognostics and response prediction
Published in JHEP reports (01-04-2022)“…Clinical routine in hepatology involves the diagnosis and treatment of a wide spectrum of metabolic, infectious, autoimmune and neoplastic diseases. Clinicians…”
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Abstract 3968: OT-101/Chemotherapy - A novel mechanism of action (MOA) in pancreatic cancer immunization therapy
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…Abstract Background: OT-101 is a phosphorothioate antisense oligodeoxynucleotide targeting the human TGF-β2 mRNA. OT-101 breaks down immune tolerance and…”
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Breaking immune tolerance for the treatment of pancreatic cancer: Phase I/II clinical experience
Published in Journal of clinical oncology (10-03-2019)“…Abstract only 54 Background: Escalating Intratumoral heterogeneity resulting in xenogenization which is countered by overexpression of TGF-β. Here we report on…”
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Breaking immune tolerance for the treatment of glioblastoma: Phase IIb clinical trial experience
Published in Journal of clinical oncology (10-03-2019)“…Abstract only 71 Background: Intratumoral heterogeneity (IH) resulting in the temporal and spatial diversification of tumor subclones. IH occurs progressively…”
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Design of an Indirectly Coupled Filter Building Block for Modular Interleaved AC-DC Converters
Published in IEEE transactions on power electronics (01-11-2022)“…This article presents the analysis and realization of a modular interconnected filter building block (FBB) operating under a single and multichannel (parallel…”
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Performance Evaluation of Feature Detectors and Descriptors Beyond the Visible
Published in Journal of intelligent & robotic systems (01-09-2018)“…Feature detection and description algorithms represent an important milestone in most computer vision applications. They have been examined from various…”
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Abstract 5029: OT-101/Chemotherapy- A novel mechanism of action (MOA) in glioblastoma immunization therapy
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…Abstract Background: Escalating Intratumoral heterogeneity (IH) resulting in xenogenization which is countered by overexpression of TGF-β2. OT-101 is a…”
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ATIM-10. CLINICAL PREDICTORS OF RESPONSE FOR RECURRENT/REFRACTORY GLIOBLASTOMA MULTIFORME (GBM) AND ANAPLASTIC ASTROCYTOMA (AA, WHO GRADE III) PATIENTS TREATED WITH THE ANTI-TGFß2 RNA THERAPEUTIC OT-101
Published in Neuro-oncology (Charlottesville, Va.) (11-11-2019)“…Abstract BACKGROUND OT-101 is a first-in-class αTGF-ß2 RNA therapeutic and exhibits significant single-agent activity in patients with recurrent/refractory…”
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ATIM-06. TREATMENT OF RECURRENT/REFRACTORY (R/R) ANAPLASTIC ASTROCYTOMA (AA, WHO GRADE 3) PATIENTS WITH ANTI-TGFß2 RNA THERAPEUTIC OT-101 VERSUS TEMOZOLOMIDE IS ASSOCIATED WITH IMPROVED OVERALL SURVIVAL
Published in Neuro-oncology (Charlottesville, Va.) (11-11-2019)“…Abstract BACKGROUND OT-101 is a first-in-class RNA therapeutic designed to disrupt the immunosuppressive action of TGFß2. During Phase 1 clinical trials,…”
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