Search Results - "Nakazawa, Michael"

Oxygen availability and metabolic adaptations by Nakazawa, Michael S., Keith, Brian, Simon, M. Celeste

“…Key Points Tumour microenvironments harbour multiple microdomains whereby cells experience limited (and highly variable) access to oxygen and nutrients. Oxygen…”
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Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma by RADER, Julieann, RUSSELL, Mike R, SUNKYU KIM, PARASURAMAN, Sudha, CAPONIGRO, Giordano, SCHNEPP, Robert W, WOOD, Andrew C, PAWEL, Bruce, COLE, Kristina A, MARIS, John M, HART, Lori S, NAKAZAWA, Michael S, BELCASTRO, Lili T, MARTINEZ, Daniel, YIMEI LI, CARPENTER, Erica L, ATTIYEH, Edward F, DISKIN, Sharon J

“…Neuroblastoma is a pediatric cancer that continues to exact significant morbidity and mortality. Recently, a number of cell-cycle proteins, particularly those…”
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Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis by Eisinger-Mathason, T S Karin, Zhang, Minsi, Qiu, Qiong, Skuli, Nicolas, Nakazawa, Michael S, Karakasheva, Tatiana, Mucaj, Vera, Shay, Jessica E S, Stangenberg, Lars, Sadri, Navid, Puré, Ellen, Yoon, Sam S, Kirsch, David G, Simon, M Celeste

“…Intratumoral hypoxia and expression of hypoxia-inducible factor-1α (HIF-1α) correlate with metastasis and poor survival in patients with sarcoma. We show here…”
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Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis by Eisinger-Mathason, T. S. Karin, Mucaj, Vera, Biju, Kevin M., Nakazawa, Michael S., Gohil, Mercy, Cash, Timothy P., Yoon, Sam S., Skuli, Nicolas, Park, Kyung Min, Gerecht, Sharon, Simon, M. Celeste

“…Genetic aberrations responsible for soft-tissue sarcoma formation in adults are largely unknown, with targeted therapies sorely needed for this complex and…”
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Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth by Nakazawa, Michael S., Eisinger-Mathason, T. S. Karin, Sadri, Navid, Ochocki, Joshua D., Gade, Terence P. F., Amin, Ruchi K., Simon, M. Celeste

“…In soft tissue sarcomas (STS), low intratumoural O 2 (hypoxia) is a poor prognostic indicator. HIF-1α mediates key transcriptional responses to hypoxia, and…”
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MYC Degradation under Low O2 Tension Promotes Survival by Evading Hypoxia-Induced Cell Death by Wong, Waihay J., Qiu, Bo, Nakazawa, Michael S., Qing, Guoliang, Simon, M. Celeste

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The aryl hydrocarbon receptor nuclear translocator is an essential regulator of murine hematopoietic stem cell viability by Krock, Bryan L., Eisinger-Mathason, Tzipora S., Giannoukos, Dionysios N., Shay, Jessica E., Gohil, Mercy, Lee, David S., Nakazawa, Michael S., Sesen, Julie, Skuli, Nicolas, Simon, M. Celeste

“…Hypoxia-inducible factors (HIFs) are master regulators of the transcriptional response to low oxygen and play essential roles in embryonic development, tissue…”
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The Future of Targeted Therapy for Leiomyosarcoma by Denu, Ryan A, Dann, Amanda M, Keung, Emily Z, Nakazawa, Michael S, Nassif Haddad, Elise F

“…Leiomyosarcoma (LMS) is an aggressive subtype of soft tissue sarcoma that arises from smooth muscle cells, most commonly in the uterus and retroperitoneum. LMS…”
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Ischemia Induces Quiescence and Autophagy Dependence in Hepatocellular Carcinoma by Gade, Terence P F, Tucker, Elizabeth, Nakazawa, Michael S, Hunt, Stephen J, Wong, Waihay, Krock, Bryan, Weber, Charles N, Nadolski, Gregory J, Clark, Timothy W I, Soulen, Michael C, Furth, Emma E, Winkler, Jeffrey D, Amaravadi, Ravi K, Simon, M Celeste

“…Purpose To characterize hepatocellular carcinoma (HCC) cells surviving ischemia with respect to cell cycle kinetics, chemosensitivity, and molecular…”
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Utility of Clinical Next Generation Sequencing Tests in KIT/PDGFRA/SDH Wild-Type Gastrointestinal Stromal Tumors by Denu, Ryan A, Joseph, Cissimol P, Urquiola, Elizabeth S, Byrd, Precious S, Yang, Richard K, Ratan, Ravin, Zarzour, Maria Alejandra, Conley, Anthony P, Araujo, Dejka M, Ravi, Vinod, Nassif Haddad, Elise F, Nakazawa, Michael S, Patel, Shreyaskumar, Wang, Wei-Lien, Lazar, Alexander J, Somaiah, Neeta

“…The vast majority of gastrointestinal stromal tumors (GISTs) are driven by activating mutations in , , or components of the succinate dehydrogenase (SDH)…”
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Clinical characteristics and outcomes of adult alveolar rhabdomyosarcoma patients on first-line systemic therapies: A single-institution cohort by Nakazawa, Michael S, Livingston, J Andrew, Zarzour, Maria A, Bishop, Andrew J, Ratan, Ravin, Ludwig, Joseph A, Araujo, Dejka M, Somaiah, Neeta, Ravi, Vinod, Nassif, Elise F, Roland, Christina L, Lazar, Alexander J, Guadagnolo, B Ashleigh, Harrison, Douglas J, Benjamin, Robert S, Patel, Shreyaskumar R, Conley, Anthony P

“…Rhabdomyosarcomas are the most common soft tissue sarcoma in children, and pediatric alveolar rhabdomyosarcoma (ARMS) prognosis has improved based on…”
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Outcomes of Late-Line Systemic Treatment in GIST: Does Sequence Matter? by Thirasastr, Prapassorn, Sutton, Thomas L, Joseph, Cissimol P, Lin, Heather, Amini, Behrang, Mayo, Skye C, Araujo, Dejka, Benjamin, Robert S, Conley, Anthony P, Livingston, John A, Ludwig, Joseph, Patel, Shreyaskumar, Ratan, Ravin, Ravi, Vinod, Zarzour, Maria A, Nassif Haddad, Elise F, Nakazawa, Michael S, Zhou, Xiao, Heinrich, Michael C, Somaiah, Neeta

“…Ripretinib and avapritinib have demonstrated activity in the late-line treatment of gastrointestinal stomal tumors (GISTs). We investigated whether patients…”
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Complete loss of TP53 and RB1 is associated with complex genome and low immune infiltrate in pleomorphic rhabdomyosarcoma by Beird, Hannah C., Wu, Chia-Chin, Nakazawa, Michael, Ingram, Davis, Daniele, Joseph R., Lazcano, Rossana, Little, Latasha, Davies, Christopher, Daw, Najat C., Wani, Khalida, Wang, Wei-Lien, Song, Xingzhi, Gumbs, Curtis, Zhang, Jianhua, Rubin, Brian, Conley, Anthony, Flanagan, Adrienne M., Lazar, Alexander J., Futreal, P. Andrew

“…Rhabdomyosarcoma accounts for roughly 1% of adult sarcomas, with pleomorphic rhabdomyosarcoma (PRMS) as the most common subtype. Survival outcomes remain poor…”
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Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia‐inducible factor 1α by Kim, Yeo‐Jung, Lee, Hae‐June, Kim, Tae‐Min, Eisinger‐Mathason, T.S. Karin, Zhang, Alexia Y., Schmidt, Benjamin, Karl, Daniel L., Nakazawa, Michael S., Park, Peter J., Simon, M. Celeste, Yoon, Sam S.

“…Increased levels of hypoxia and hypoxia‐inducible factor 1α (HIF‐1α) in human sarcomas correlate with tumor progression and radiation resistance. Prolonged…”
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Abstract 5661: Identifying and intervening rare resistant subclones to BRAF/MEK inhibitors in metastatic melanoma by Wang, Han, Nakazawa, Michael, Veiseh, Omid, Kwong, Lawrence, Zhang, David

“…Acquired drug resistance poses a significant challenge in the treatment of cancer. This study focuses on melanoma as a model system to understand and address…”
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Clinically relevant genomic alterations identified by targeted exome sequencing in U.S. veterans with prostate cancer by Dadashian, Eman, Nakazawa, Michael, Parikh, Neil Rohit, Kalpage, Nathisha, Nickols, Nicholas George, Rettig, Matthew

“…Abstract only e17599 Background: Amongst male United States Veterans, prostate cancer accounts for one third of cancer diagnoses and is the second leading…”
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MYC Degradation under Low O 2 Tension Promotes Survival by Evading Hypoxia-Induced Cell Death by Wong, Waihay J., Qiu, Bo, Nakazawa, Michael S., Qing, Guoliang, Simon, M. Celeste

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Clinical characteristics and outcomes of adult alveolar rhabdomyosarcoma (ARMS) patients on front-line therapies: An MD Anderson Cancer Center (MDACC) case series by Nakazawa, Michael, Livingston, J Andrew Andrew, Bishop, Andrew Justin, Zarzour, Maria Alejandra, Somaiah, Neeta, Ratan, Ravin, Gill, Jonathan Benjamin, Urquiola, Elizabeth, Posey, Kristi, Guadagnolo, Beverly Ashleigh, Gorlick, Richard Greg, Benjamin, Robert S., Patel, Shreyaskumar, Conley, Anthony Paul

“…e23548 Background: Rhabdomyosarcomas are the most common soft tissue sarcoma in children, and the prognosis of pediatric ARMS has improved with the use of…”
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Loss of the DNA repair gene RNase H2 and a unique subset of DDR-deficient leiomyosarcomas by Nakazawa, Michael, Silverman, Ian M., Rimkunas, Victoria, Veloso, Artur, Glodzik, Dominik, Patel, Shreyaskumar, Roland, Christina Lynn, Soliman, Pamela T., Beird, Hannah, Wu, Chia-Chin, Ingram, Davis, Lazcano Segura, Rossana, Wani, Khalida M, Lazar, Alexander J., Yap, Timothy A., Wang, Wei-Lien, Livingston, J Andrew Andrew

“…11549 Background: Targeting the DNA damage response (DDR)/Homologous Recombination (HR) pathway is an emerging therapeutic approach for leiomyosarcoma (LMS)…”
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Abstract 1012: Detecting and intervening on rare pre-existing resistant subclones to BRAF/MEK inhibitors in metastatic melanoma by Nakazawa, Michael, Cheng, Lauren, Ahmed, Mishal, Lazcano, Rossana, Wani, Khalida, Veiseh, Omid, Kwong, Lawrence

“…The combination of BRAF and MEK inhibitors (BRAFi/MEKi) in metastatic melanoma patients with BRAF activating mutations have resulted in dramatic responses in…”
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