Search Results - "Nakayamada, Shingo"

Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach by Tanaka, Yoshiya, Luo, Yiming, O’Shea, John J., Nakayamada, Shingo

“…The four Janus kinase (JAK) proteins and seven signal transducer and activator of transcription (STAT) transcription factors mediate intracellular signal…”
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Preferable outcome of Janus kinase inhibitors for a group of difficult-to-treat rheumatoid arthritis patients: from the FIRST Registry by Ochi, Sae, Sonomoto, Koshiro, Nakayamada, Shingo, Tanaka, Yoshiya

“…Treatment of difficult-to-treat rheumatoid arthritis (D2T RA) is one of the greatest unmet needs in rheumatology. This study aims to find out preferable…”
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Predictors of functional improvement and pain reduction in rheumatoid arthritis patients who achieved low disease activity with disease-modifying antirheumatic drugs: a retrospective study of the FIRST Registry by Ochi, Sae, Sonomoto, Koshiro, Nakayamada, Shingo, Tanaka, Yoshiya

“…Rheumatoid arthritis (RA) patients sometimes exhibit different levels of improvement in health assessment questionnaire-disability index (HAQ-DI) and…”
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Metabolic Reprogramming Commits Differentiation of Human CD27 + IgD + B Cells to Plasmablasts or CD27 - IgD - Cells by Torigoe, Masataka, Iwata, Shigeru, Nakayamada, Shingo, Sakata, Kei, Zhang, Mingzeng, Hajime, Maiko, Miyazaki, Yusuke, Narisawa, Manabu, Ishii, Koji, Shibata, Hirotaka, Tanaka, Yoshiya

“…B cells play a crucial role in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE). However, the relevance of the metabolic…”
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Development of targeted therapies in IgG4-related disease by Nakayamada, Shingo, Tanaka, Yoshiya

“…ABSTRACT IgG4-related disease (IgG4-RD) is a systemic disease characterized by high serum IgG4 levels, infiltration of lymphocytes and IgG4-positive plasma…”
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Janus kinases to jakinibs: from basic insights to clinical practice by Gadina, Massimo, Le, Mimi T, Schwartz, Daniella M, Silvennoinen, Olli, Nakayamada, Shingo, Yamaoka, Kunihiro, O'Shea, John J

“…Abstract Cytokines are critical mediators of diverse immune and inflammatory diseases. Targeting cytokines and cytokine receptors with biologics has…”
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Multi-Source Pathways of T Follicular Helper Cell Differentiation by Ma, Xiaoxue, Nakayamada, Shingo

“…T follicular helper (Tfh) cells participate in humoral immune by promoting inflammation and aiding B cells survival, proliferation, maturation, and generation…”
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Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach by Tanaka, Yoshiya, Luo, Yiming, O’Shea, John J., Nakayamada, Shingo

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Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells by Miyagawa, Ippei, Nakayamada, Shingo, Nakano, Kazuhisa, Yamagata, Kaoru, Sakata, Kei, Yamaoka, Kunihiro, Tanaka, Yoshiya

“…Human mesenchymal stem cells (MSCs) are multipotent and exert anti-inflammatory effects, but the underlying mechanism remains to be elucidated. In the current…”
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Immune Phenotype as a Biomarker for Systemic Lupus Erythematosus by Nakayamada, Shingo, Tanaka, Yoshiya

“…The treatment of rheumatoid arthritis was revolutionized with the use of molecular-targeted drugs that target immunoregulatory molecules. The success of…”
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Up-Regulation of TLR7-Mediated IFN-α Production by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus by Sakata, Kei, Nakayamada, Shingo, Miyazaki, Yusuke, Kubo, Satoshi, Ishii, Akina, Nakano, Kazuhisa, Tanaka, Yoshiya

“…Aberrant and persistent production of interferon-α (IFN-α) by plasmacytoid dendritic cells (pDCs) is known to play a key role in the pathogenesis of systemic…”
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Janus Kinase Inhibitor Baricitinib Modulates Human Innate and Adaptive Immune System by Kubo, Satoshi, Nakayamada, Shingo, Sakata, Kei, Kitanaga, Yukihiro, Ma, Xiaoxue, Lee, Seunghyun, Ishii, Akina, Yamagata, Kaoru, Nakano, Kazuhisa, Tanaka, Yoshiya

“…The purpose of this study was to elucidate the mechanism of action of baricitinib on Janus kinase (JAK)/signal transducer and activator of transcription (STAT)…”
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Comprehensive immunophenotypic analysis reveals the pathological involvement of Th17 cells in Graves' disease by Torimoto, Keiichi, Okada, Yosuke, Nakayamada, Shingo, Kubo, Satoshi, Kurozumi, Akira, Narisawa, Manabu, Tanaka, Yoshiya

“…Graves' disease (GD) is an organ-specific autoimmune disease, but there are a few studies that have evaluated how immunophenotypes are related to clinical…”
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Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases by Hao, He, Nakayamada, Shingo, Tanaka, Yoshiya

“…T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However,…”
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Recent Progress in JAK Inhibitors for the Treatment of Rheumatoid Arthritis by Nakayamada, Shingo, Kubo, Satoshi, Iwata, Shigeru, Tanaka, Yoshiya

“…Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by synovial inflammation and joint destruction. Considerable advance in the treatment…”
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Interleukin-23 drives expansion of Thelper 17 cells through epigenetic regulation by signal transducer and activators of transcription 3 in lupus patients by Lee, Seunghyun, Nakayamada, Shingo, Kubo, Satoshi, Yamagata, Kaoru, Yoshinari, Hiroko, Tanaka, Yoshiya

“…Abstract Objectives To elucidate the molecular mechanisms underlying pathogenic Th17 cells, we investigated the modulation of epigenetic modifications and its…”
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Rituximab in the real-world treatment of lupus nephritis: A retrospective cohort study in Japan by Tanaka, Yoshiya, Nakayamada, Shingo, Yamaoka, Kunihiro, Ohmura, Koichiro, Yasuda, Shinsuke

“…Although recommended in established international guidelines for lupus nephritis (LN), rituximab is not officially approved for LN treatment, making all such…”
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An enhanced mitochondrial function through glutamine metabolism in plasmablast differentiation in systemic lupus erythematosus by Sumikawa, Maiko Hajime, Iwata, Shigeru, Zhang, Mingzeng, Miyata, Hiroko, Ueno, Masanobu, Todoroki, Yasuyuki, Nagayasu, Atsushi, Kanda, Ryuichiro, Sonomoto, Koshiro, Torimoto, Keiichi, Lee, Seunghyun, Nakayamada, Shingo, Yamamoto, Kazuo, Okada, Yosuke, Tanaka, Yoshiya

“…Abstract Objective To evaluate the dysfunction of B-cell metabolism and its involvement in SLE pathology. Methods We assessed the expression of metabolic…”
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Lymphocyte phenotype and its application to precision medicine in systemic autoimmune diseases by Tanaka, Yoshiya, Kubo, Satoshi, Miyagawa, Ippei, Iwata, Shigeru, Nakayamada, Shingo

“…Systemic lupus erythematosus (SLE) is a representative autoimmune disease characterized by multiple organ manifestations but is molecularly and genetically…”
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Involvement of lncRNA IL21-AS1 in interleukin-2 and T follicular regulatory cell activation in systemic lupus erythematosus by Hao, He, Nakayamada, Shingo, Ohkubo, Naoaki, Yamagata, Kaoru, Zhang, Mingzeng, Shan, Yu, Iwata, Shigeru, Zhang, Tong, Tanaka, Yoshiya

“…The single nucleotide polymorphism (SNP) rs62324212, located in IL21 antisense RNA 1 (IL21-AS1), has been identified as a genetic risk variant associated with…”
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