Search Results - "Nakayama, Taku"

Key transporters leading to specific protoporphyrin IX accumulation in cancer cell following administration of aminolevulinic acid in photodynamic therapy/diagnosis by Lai, Hung Wei, Nakayama, Taku, Ogura, Shun-ichiro

“…The administration of aminolevulinic acid allow the formation and accumulation of protoporphyrin IX specifically in cancer cells, which then lead to…”
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Water-promoted dehydrative coupling of 2-aminopyridines in heptane via a borrowing hydrogen strategy by Nakayama, Taku, Hikawa, Hidemasa, Kikkawa, Shoko, Azumaya, Isao

“…A synthetic method for dehydrative -benzylation promoted by water molecules in heptane using a π-benzylpalladium system has been developed. The presence of…”
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Enhanced lipid metabolism induces the sensitivity of dormant cancer cells to 5-aminolevulinic acid-based photodynamic therapy by Nakayama, Taku, Sano, Tomonori, Oshimo, Yoshiki, Kawada, Chiaki, Kasai, Moe, Yamamoto, Shinkuro, Fukuhara, Hideo, Inoue, Keiji, Ogura, Shun-ichiro

“…Cancer can develop into a recurrent metastatic disease with latency periods of years to decades. Dormant cancer cells, which represent a major cause of…”
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An Azide-Tethered Cremophor® ELP Surfactant Allowing Facile Post-Surface Functionalization of Nanoemulsions by Saito, Airi, Yamamoto, Shinkuro, Ochi, Rika, Inoue, Keiji, Hadano, Shingo, Watanabe, Shigeru, Nakayama, Taku, Niko, Yosuke

“…Nanoemulsions (NEs) comprising Labrafac WC® as an inner oil and Cremophor® ELP as an outer surfactant are promising organic nanoparticles for biomedical…”
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Lipophilic Nitrile N-Oxide for Catalyst-Free Surface Modification of Nanoemulsions as Light-Harvesting Nanoantennas by Kaneko, Masuomi, Nakayama, Taku, Seki, Hitomi, Yamamoto, Shinkuro, Uemura, Takumi, Inoue, Keiji, Hadano, Shingo, Watanabe, Shigeru, Niko, Yosuke

“…The therapeutic and diagnostic applications of nanoemulsions (NEs) are restricted by a lack of suitable methods to modify their surfaces, specifically the…”
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Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy by Nakayama, Taku, Otsuka, Shimpei, Kobayashi, Tatsuya, Okajima, Hodaka, Matsumoto, Kentaro, Hagiya, Yuichiro, Inoue, Keiji, Shuin, Taro, Nakajima, Motowo, Tanaka, Tohru, Ogura, Shun-ichiro

“…Photodynamic therapy (PDT) and diagnosis (PDD) using 5-aminolevulinic acid (ALA) to drive the production of an intracellular photosensitizer, protoporphyrin IX…”
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Evolution of photodynamic medicine based on fluorescence image-guided diagnosis using indocyanine green and 5-aminolevulinic acid by Namikawa, Tsutomu, Iwabu, Jun, Munekage, Masaya, Uemura, Sunao, Maeda, Hiromichi, Kitagawa, Hiroyuki, Nakayama, Taku, Inoue, Keiji, Sato, Takayuki, Kobayashi, Michiya, Hanazaki, Kazuhiro

“…New diagnostic techniques based on photodynamic medicine, such as near-infrared fluorescence using indocyanine green (NIR-ICG) and 5-aminolevulinic…”
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Photoirradiation after aminolevulinic acid treatment suppresses cancer cell proliferation through the HO-1/p21 pathway by Nakayama, Taku, Kobayashi, Tatsuya, Shimpei, Otsuka, Fukuhara, Hideo, Namikawa, Tsutomu, Inoue, Keiji, Hanazaki, Kazuhiro, Takahashi, Kiwamu, Nakajima, Motowo, Tanaka, Tohru, Ogura, Shun-ichiro

“…•p21 was upregulated using photoirradiation after ALA treatment in HEK293 cells.•These expression changes were abrogated by a reactive oxygen species…”
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Laparoscopic‐endoscopic cooperative surgery for early gastric cancer with gastroesophageal varices by Namikawa, Tsutomu, Iwabu, Jun, Munekage, Masaya, Uemura, Sunao, Maeda, Hiromichi, Kitagawa, Hiroyuki, Nakayama, Taku, Fukuhara, Hideo, Inoue, Keiji, Al‐Sheikh, Mariam, Jaiswal, Nalin, Kobayashi, Michiya, Hanazaki, Kazuhiro

“…This report describes a patient with early gastric cancer with gastroesophageal varices who underwent laparoscopic‐endoscopic cooperative surgery. The patient,…”
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Direct Use of Benzylic Alcohols for Multicomponent Synthesis of 2‐Aryl Quinazolinones Utilizing the π‐Benzylpalladium(II) System in Water by Hikawa, Hidemasa, Nakayama, Taku, Takahashi, Makiko, Kikkawa, Shoko, Azumaya, Isao

“…We demonstrate the direct use of benzylic alcohols for a multicomponent reaction of readily available isatoic anhydrides with amines in water, which is a…”
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Pd(0)/TPPMS‐Catalyzed Tsuji–Trost Type Cross‐Coupling of Allylic Alcohols with Organoboron Compounds in Water by Hikawa, Hidemasa, Fu, Chuan, Nakayama, Taku, Kikkawa, Shoko, Azumaya, Isao

“…We demonstrated that the combination of a Pd(0) catalyst and a water‐soluble TPPMS ligand has high activity for the direct arylation of readily available…”
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Effect of Br···O Bonding on the Chiral Assembly of Brominated Amides in the Crystalline Phase by Kikkawa, Shoko, Takeno, Miho, Nakayama, Taku, Koike, Daiki, Saito, Yuuki, Tashiro, Masako, Aoyama, Yu, Hikawa, Hidemasa, Azumaya, Isao

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Cocrystal or Salt Crystallization for Active Pharmaceutical Ingredients By Using Deep Eutectic Solvents by Ito, Masataka, Iwata, Yuriko, Iwasaki, Hiroyasu, Hayashi, Kyu, Nakayama, Taku, Hikawa, Hidemasa, Azumaya, Isao, Suzuki, Hironori, Noguchi, Shuji

“…Active pharmaceutical ingredients (APIs) often exhibit physicochemical problems that one can remedy by various methods (e.g., salt formation, grinding, ordered…”
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New synthetic method for ring-fused quinazoline by palladium-catalyzed oxidative cyclization of 2-aminobenzyl alcohol: Chiral separation and structural analysis by Enda, Tomokatsu, Nakayama, Taku, Suzuki, Kento, Kikkawa, Shoko, Hikawa, Hidemasa, Azumaya, Isao

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Palladium‐Catalyzed Dehydrogenative Synthesis of Imidazoquinolines in Water by Nakayama, Taku, Harada, Shogo, Kikkawa, Shoko, Hikawa, Hidemasa, Azumaya, Isao

“…We report a synthesis of imidazoquinolines via dehydrogenative coupling of 3,4‐diaminoquinolines with benzylic alcohols utilizing our π‐benzylpalladium(II)…”
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Pd(II)‐Catalyzed Aerobic Alcohol Oxidation for Multicomponent Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones in Water by Kobayashi, Masakazu, Kataoka, Sayaka, Nakayama, Taku, Kikkawa, Shoko, Hikawa, Hidemasa, Azumaya, Isao

“…We describe a multicomponent reaction between isatoic anhydrides, alkylamines and benzylic alcohols using Pd(II)/TPPMS catalyst with cocatalytic Cu(II) salt in…”
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Predictors of therapeutic efficacy of 5-aminolevulinic acid-based photodynamic therapy in human prostate cancer by Yamamoto, Shinkuro, Fukuhara, Hideo, Seki, Hitomi, Kawada, Chiaki, Nakayama, Taku, Karashima, Takashi, Ogura, Shun-ichiro, Inoue, Keiji

“…•Intracellular protoporphyrin IX accumulation and cytotoxicity of ALA-PDT differ among prostate cancer cell lines.•Analysis of the expression level of ABCG2…”
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Water-promoted dehydrative coupling of 2-aminopyridines in heptane a borrowing hydrogen strategy by Nakayama, Taku, Hikawa, Hidemasa, Kikkawa, Shoko, Azumaya, Isao

“…A synthetic method for dehydrative N -benzylation promoted by water molecules in heptane using a π-benzylpalladium system has been developed. The presence of…”
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Mitomycin C-induced cell cycle arrest enhances 5-aminolevulinic acid-based photodynamic therapy for bladder cancer by Nakayama, Taku, Nozawa, Naoko, Kawada, Chiaki, Yamamoto, Shinkuro, Ishii, Takuya, Ishizuka, Masahiro, Namikawa, Tsutomu, Ogura, Shun-ichiro, Hanazaki, Kazuhiro, Inoue, Keiji, Karashima, Takashi

“…[Display omitted] •Mitomycin C caused G2/M cell cycle arrest in T24 bladder carcinoma cells.•PEPT1 and ABCG2 were dramatically upregulated by mitomycin…”
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Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery by Morisawa, Shumpei, Jobu, Kohei, Ishida, Tomoaki, Kawada, Kei, Fukuda, Hitoshi, Kawanishi, Yu, Nakayama, Taku, Yamamoto, Shinkuro, Tamura, Naohisa, Takemura, Mitsuhiro, Kagimoto, Nao, Ohta, Tsuyoshi, Masahira, Noritaka, Fukuhara, Hideo, Ogura, Shun-ichiro, Ueba, Tetsuya, Inoue, Keiji, Miyamura, Mitsuhiko

“…•5-ALA was associated with low blood pressure in malignant glioma surgery.•Intraoperative hypotension was associated with increasing age.•RAS inhibitors boost…”
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